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1.发明申请METHODS OF TREATING MOOD DISORDERS USING BENZISOXAZOLE CONTAINING DIAZABICYCLIC COMPOUNDS 审中-公开使用含有双唑氧化合物的双歧杆菌化合物处理细菌病症的方法
公开(公告)号：WO2006027691A3
公开(公告)日：2006-06-08
申请号：PCT/IB2005002913
申请日：2005-09-01
Applicant: PFIZER PROD INC , ICE KATHLEEN SUE , SNYDER PETER JEFFREY , WATSKY ERIC JACOB
Inventor： ICE KATHLEEN SUE , SNYDER PETER JEFFREY , WATSKY ERIC JACOB
IPC: A61K31/495 , A61P25/00
CPC classification number: A61K31/495
Abstract: A benzisoxazole substituted azabicyclic compound, a pharmaceutical composition comprising same, and a method of treating a mood disorder selected from the group consisting of Somatization Disorder, Borderline Personality Disorder, Narcissistic Personality Disorder, Suicidal Ideation, and Antisocial Personality Disorder.
Abstract translation: 苯并异恶唑取代的氮杂双环化合物，包含其的药物组合物，以及治疗选自体细胞紊乱，边缘人格障碍，自恋人格障碍，自杀意念和反社会人格障碍的情绪障碍的方法。
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2.发明申请NUCLEIC ACID MOLECULES, POLYPEPTIDES AND USES THEREFOR, INCLUDING DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE 审中-公开核酸分子，多肽及其用途，包括诊断和治疗阿尔茨海默病
公开(公告)号：WO2003028543A2
公开(公告)日：2003-04-10
申请号：PCT/US2002/031642
申请日：2002-10-03
Applicant: PFIZER PRODUCTS INC. , OXFORD GLYCOSCIENCES (UK) LTD. , DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
Inventor： DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
IPC: A61B
CPC classification number: G01N33/6896 , C07K14/4711 , C07K16/18 , G01N2333/4709 , G01N2500/00 , G01N2800/2821 , G01N2800/52
Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
Abstract translation: 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默病相关特征（AF）。 本发明进一步提供在脑脊液，血清或血浆中可检测的阿尔茨海默病相关蛋白质异构体（API），包含针对API免疫特异性的分离的API抗体的制剂，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。
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3.发明申请METHODS OF TREATING MOOD DISORDERS USING PYRIDYLOXYMETHYL AND BENZISOXAZOLE AZABICYCLIC DERIVATIVES 审中-公开使用吡咯烷基甲基和苯并恶唑偶氮衍生物处理细菌病症的方法
公开(公告)号：WO2006027691A2
公开(公告)日：2006-03-16
申请号：PCT/IB2005/002913
申请日：2005-09-01
Applicant: PFIZER PRODUCTS INC. , ICE, Kathleen, Sue , SNYDER, Peter, Jeffrey , WATSKY, Eric, Jacob
Inventor： ICE, Kathleen, Sue , SNYDER, Peter, Jeffrey , WATSKY, Eric, Jacob
IPC: A61K31/495 , A61P25/00
CPC classification number: A61K31/495
Abstract: An aminomethylpyridyloxymethyl/benzisoxazole substituted azabicyclic compound, a pharmaceutical composition comprising same, and a method of treating a mood disorder selected from the group consisting of Somatization Disorder, Borderline Personality Disorder, Narcissistic Personality Disorder, Suicidal Ideation, and Antisocial Personality Disorder.
Abstract translation: 氨基甲基吡啶氧基甲基/苯并异恶唑取代的氮杂双环化合物，包含其的药物组合物和治疗选自由躯体化障碍，边缘人格障碍，自恋人格障碍，自杀意念和反社会人格障碍组成的组的情绪障碍的方法。
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4.发明申请
公开(公告)号：WO2003028543A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/031642
申请日：2002-10-03
Applicant: PFIZER PRODUCTS INC. , OXFORD GLYCOSCIENCES (UK) LTD. , DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
Inventor： DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
IPC: C07K5/00
Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.
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