发明申请
WO03048108A3 COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS
审中-公开
用于治疗炎症，糖尿病和相关疾病的化合物
- 专利标题： COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS
- 专利标题（中）： 用于治疗炎症，糖尿病和相关疾病的化合物
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申请号： PCT/US0238150申请日： 2002-11-27
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公开(公告)号： WO03048108A3公开(公告)日： 2003-10-16
- 发明人: NEOGI PARTHA , DEY DEBENDRANATH , LI TA-KAI , FULLER JOSEPH , CHEN LIANG
- 申请人： CALYX THERAPEUTICS INC , NEOGI PARTHA , DEY DEBENDRANATH , LI TA-KAI , FULLER JOSEPH , CHEN LIANG
- 专利权人： CALYX THERAPEUTICS INC,NEOGI PARTHA,DEY DEBENDRANATH,LI TA-KAI,FULLER JOSEPH,CHEN LIANG
- 当前专利权人： CALYX THERAPEUTICS INC,NEOGI PARTHA,DEY DEBENDRANATH,LI TA-KAI,FULLER JOSEPH,CHEN LIANG
- 优先权： US33481801 2001-11-29
- 主分类号： A61P3/10
- IPC分类号： A61P3/10 ; C07C233/25 ; C07C235/34 ; C07C235/56 ; C07C237/22 ; C07C271/16 ; C07C271/64 ; C07C275/50 ; C07C281/06 ; C07C317/22 ; C07D213/56 ; C07D213/64 ; C07D213/643 ; C07D213/75 ; C07D295/185 ; A61K31/16 ; A61K31/17 ; A61K31/175 ; A61K31/19 ; A61K31/216 ; A61K31/27 ; A61K31/36 ; A61K31/44 ; C07C235/28 ; C07C335/26 ; C07D295/182 ; C07D317/60
摘要：
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
