Invention Application
WO2005012479A2 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF
审中-公开
抗体指导表皮生长因子受体的缺失突变及其应用
- Patent Title: ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF
- Patent Title (中): 抗体指导表皮生长因子受体的缺失突变及其应用
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Application No.: PCT/US2004/020564Application Date: 2004-06-25
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Publication No.: WO2005012479A2Publication Date: 2005-02-10
- Inventor: WEBER, Richard , FENG, Xiao , FOORD, Orit , GREEN, Larry , GUDAS, Jean , KEYT, Bruce , LIU, Ying , RATHANASWAMI, Palani , RAYA, Robert , YANG, Xiao, Dong , CORVALAN, Jose , FOLTZ, Ian , JIA, Xiao-Chi , KANG, Jaspal , KING, Chadwick, T. , KLAKAMP, Scott, L. , SU, Qiaojuan, Jane
- Applicant: ABGENIX, INC , WEBER, Richard , FENG, Xiao , FOORD, Orit , GREEN, Larry , GUDAS, Jean , KEYT, Bruce , LIU, Ying , RATHANASWAMI, Palani , RAYA, Robert , YANG, Xiao, Dong , CORVALAN, Jose , FOLTZ, Ian , JIA, Xiao-Chi , KANG, Jaspal , KING, Chadwick, T. , KLAKAMP, Scott, L. , SU, Qiaojuan, Jane
- Applicant Address: 6701 Kaiser Drive, Fremont, California 94555 US
- Assignee: ABGENIX, INC,WEBER, Richard,FENG, Xiao,FOORD, Orit,GREEN, Larry,GUDAS, Jean,KEYT, Bruce,LIU, Ying,RATHANASWAMI, Palani,RAYA, Robert,YANG, Xiao, Dong,CORVALAN, Jose,FOLTZ, Ian,JIA, Xiao-Chi,KANG, Jaspal,KING, Chadwick, T.,KLAKAMP, Scott, L.,SU, Qiaojuan, Jane
- Current Assignee: ABGENIX, INC,WEBER, Richard,FENG, Xiao,FOORD, Orit,GREEN, Larry,GUDAS, Jean,KEYT, Bruce,LIU, Ying,RATHANASWAMI, Palani,RAYA, Robert,YANG, Xiao, Dong,CORVALAN, Jose,FOLTZ, Ian,JIA, Xiao-Chi,KANG, Jaspal,KING, Chadwick, T.,KLAKAMP, Scott, L.,SU, Qiaojuan, Jane
- Current Assignee Address: 6701 Kaiser Drive, Fremont, California 94555 US
- Agency: HART, Daniel
- Priority: US60/483,145 20030627; US60/525,570 200301126; US60/562,453 20040415
- Main IPC: C12N
- IPC: C12N
Abstract:
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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