公开(公告)号：WO2009143472A3

公开(公告)日：2010-03-11

申请号：PCT/US2009045052

申请日：2009-05-22

Applicant: ALIVA BIOPHARMACEUTICALS INC ,  SHIZUYA HIROAKI ,  GREEN LARRY

Inventor： SHIZUYA HIROAKI ,  GREEN LARRY

IPC: C07K16/46 ,  A01K67/027 ,  A61K39/395 ,  C07K16/18 ,  C12N5/10 ,  C12N15/13

CPC classification number: A01K67/0275 ,  A01K2217/00 ,  A01K2267/01 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/569 ,  C07K2319/00 ,  C12N15/8509

Abstract: The present invention describes methods of generating single VL domain antibodies, including chimeric single chain antibodies that comprise of a variable region of a human immunoglobulin ? or ? light chain and a non-human constant region. The non-human constant region is devoid of a first constant domain CH1, and the variable region is devoid of a heavy chain variable domain.

Abstract translation: 本发明描述了产生单一VL结构域抗体的方法，包括包含人免疫球蛋白β的可变区的嵌合单链抗体 要么 ？ 轻链和非人类恒定区。 非人恒定区缺少第一恒定结构域CH1，并且可变区缺失重链可变结构域。

公开(公告)号：WO2006081139A3

公开(公告)日：2007-02-15

申请号：PCT/US2006002011

申请日：2006-01-19

Applicant: ABGENIX INC ,  GREEN LARRY ,  FAGGIONI RAFFAELLA ,  FOORD ORIT ,  KLAKAMP SCOTT L ,  SENALDI GIORGIO ,  SCHNEIDER AMY K

Inventor： GREEN LARRY ,  FAGGIONI RAFFAELLA ,  FOORD ORIT ,  KLAKAMP SCOTT L ,  SENALDI GIORGIO ,  SCHNEIDER AMY K

IPC: C07K16/00 ,  A61K39/00 ,  A61K39/395

CPC classification number: C07K16/245 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S424/801 ,  Y10S530/867

Abstract: Antibodies directed to the antigen IL-1ß and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen IL-1ß are discussed. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are described.

Abstract translation: 描述了针对抗原IL-1β的抗体和这种抗体的用途。 特别地，讨论了针对抗原IL-1β的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 描述了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：WO2005012479A3

公开(公告)日：2006-10-12

申请号：PCT/US2004020564

申请日：2004-06-25

Applicant: ABGENIX INC ,  WEBER RICHARD ,  FENG XIAO ,  FOORD ORIT ,  GREEN LARRY ,  GUDAS JEAN ,  KEYT BRUCE ,  LIU YING ,  RATHANASWAMI PALANI ,  RAYA ROBERT ,  YANG XIAO DONG ,  CORVALAN JOSE ,  FOLTZ IAN ,  JIA XIAO-CHI ,  KANG JASPAL ,  KING CHADWICK T ,  KLAKAMP SCOTT L ,  SU QIAOJUAN JANE

Inventor： WEBER RICHARD ,  FENG XIAO ,  FOORD ORIT ,  GREEN LARRY ,  GUDAS JEAN ,  KEYT BRUCE ,  LIU YING ,  RATHANASWAMI PALANI ,  RAYA ROBERT ,  YANG XIAO DONG ,  CORVALAN JOSE ,  FOLTZ IAN ,  JIA XIAO-CHI ,  KANG JASPAL ,  KING CHADWICK T ,  KLAKAMP SCOTT L ,  SU QIAOJUAN JANE

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/44 ,  A61K47/48 ,  C07H21/04 ,  C07K14/71 ,  C07K16/22 ,  C07K16/42 ,  C07K17/00 ,  C12N20060101 ,  C12N5/06 ,  C12N5/12 ,  C12P21/08 ,  G01N33/53 ,  G01N33/552 ,  G01N33/577

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract translation: 本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。 本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。 还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。

公开(公告)号：WO2006068953A2

公开(公告)日：2006-06-29

申请号：PCT/US2005/045657

申请日：2005-12-19

Applicant: ABGENIX, INC. ,  ASTRAZENECA AB ,  GREEN, Larry L. ,  ZHOU, Qing ,  KEYT, Bruce, A. ,  YANG, Xiao-dong ,  EMERY, Stephen, Charles ,  BLAKEY, David C.

Inventor： GREEN, Larry L. ,  ZHOU, Qing ,  KEYT, Bruce, A. ,  YANG, Xiao-dong ,  EMERY, Stephen, Charles ,  BLAKEY, David C.

IPC: C07K16/22 ,  C07K16/28 ,  C12N15/13 ,  C12N15/85

CPC classification number: C07K16/22 ,  A61K39/39558 ,  A61K2039/505 ,  C07K14/515 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementary determining regions (CDR’s), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobin molecules and monoclonal antibodies.

Abstract translation: 描述针对抗原Ang-2的抗体和这种抗体的用途。 特别是针对抗原Ang-2的完全人单克隆抗体。 编码重组和轻链免疫球蛋白分子的核苷酸序列和氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 杂交瘤或表达这种免疫球蛋白分子的其它细胞系和单克隆抗体。

公开(公告)号：WO2005092926A2

公开(公告)日：2005-10-06

申请号：PCT/US2005009306

申请日：2005-03-17

Applicant: ABGENIX INC ,  KELLERMANN SIRID-AIMEE ,  GREEN LARRY L ,  KORVER WOUTER

Inventor： KELLERMANN SIRID-AIMEE ,  GREEN LARRY L ,  KORVER WOUTER

IPC: C07K16/00 ,  C07K16/46 ,  G01N33/53

CPC classification number: C07K16/00 ,  C07K16/464 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56

Abstract: The present embodiments relate to methods of identifying and creating human, or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included.

Abstract translation: 本实施方案涉及鉴定和产生人或人源化抗体的方法，所述抗体或人源化抗体在施用于人宿主时具有诱导人抗人抗体（HAHA）应答的风险降低。 其他方法用于预测发生HAHA反应的可能性。 还包括用于筛选抗HAHA化合物的方法。

公开(公告)号：WO2005017107A2

公开(公告)日：2005-02-24

申请号：PCT/US2004018936

申请日：2004-07-16

Applicant: AMGEN INC ,  ABGENIX INC ,  BURGESS TERESA L ,  COXON ANGELA ,  GREEN LARRY L ,  ZHANG KE

Inventor： BURGESS TERESA L ,  COXON ANGELA ,  GREEN LARRY L ,  ZHANG KE

IPC: C07K14/74 ,  C07K16/22 ,  C07K16/28 ,  C12N20060101 ,  G01N33/53 ,  C12N

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Specific binding agents that interact with hepatocyte growth factor (HGF) are described. Methods of treating cancer by administering a pharmaceutically effective amount of a specific binding agent to HGF are described. Methods of detecting the amount of HGF in a sample using a specific binding agent to HGF are described.

Abstract translation: 描述了与肝细胞生长因子（HGF）相互作用的特异性结合剂。 描述了通过向HGF施用药学有效量的特异性结合剂来治疗癌症的方法。 描述了使用特异性结合剂向HGF检测样品中HGF的量的方法。

公开(公告)号：WO2005010151A3

公开(公告)日：2005-02-03

申请号：PCT/US2004/020295

申请日：2004-06-25

Applicant: ABGENIX, INC ,  WEBER, Richard ,  FENG, Xiao ,  FOORD, Orit ,  GREEN, Larry ,  GUDAS, Jean ,  KEYT, Bruce ,  LIU, Ying ,  RATHANASWAMI, Palani ,  RAYA, Robert ,  YANG, Xiao, Dong ,  CORVALAN, Jose ,  FOLTZ, Ian ,  JIA, Xiao-Chi ,  KANG, Jaspal ,  KING, Chadwick, T. ,  KLAKAMP, Scott, L. ,  SU, Qiaojuan, Jane

Inventor： WEBER, Richard ,  FENG, Xiao ,  FOORD, Orit ,  GREEN, Larry ,  GUDAS, Jean ,  KEYT, Bruce ,  LIU, Ying ,  RATHANASWAMI, Palani ,  RAYA, Robert ,  YANG, Xiao, Dong ,  CORVALAN, Jose ,  FOLTZ, Ian ,  JIA, Xiao-Chi ,  KANG, Jaspal ,  KING, Chadwick, T. ,  KLAKAMP, Scott, L. ,  SU, Qiaojuan, Jane

IPC: A61K39/395

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

公开(公告)号：WO2003047336A2

公开(公告)日：2003-06-12

申请号：PCT/US2002/038245

申请日：2002-11-27

Applicant: ABGENIX, INC. ,  GREEN, Larry, L. ,  IVANOV, Vladimir

Inventor： GREEN, Larry, L. ,  IVANOV, Vladimir

IPC: A01K

CPC classification number: C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/0381 ,  C07K16/00 ,  C07K16/24 ,  C07K2317/21 ,  C12N2800/206

Abstract: The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have incorporated human λ light chain loci. The invention further relates to methods of using and compositions derived from the transgenic animals that have incorporated human λ light chain loci.

Abstract translation: 本发明涉及带有一个或多个人λ轻链基因座的转基因动物。 本发明还涉及用于制备已经掺入人λ轻链基因座的转基因动物的方法和组合物。 本发明还涉及使用衍生自已经掺入人λ轻链基因座的转基因动物的方法和组合物。

公开(公告)号：WO2007061935A3

公开(公告)日：2009-05-07

申请号：PCT/US2006044843

申请日：2006-11-17

Applicant: EXXONMOBIL RES & ENG CO ,  QIAN KUANGNAN ,  OLMSTEAD WILLIAM N ,  ENGLISH JASON B ,  GREEN LARRY A ,  SAEGER ROLAND B ,  JAFFE STEPHEN B

Inventor： QIAN KUANGNAN ,  OLMSTEAD WILLIAM N ,  ENGLISH JASON B ,  GREEN LARRY A ,  SAEGER ROLAND B ,  JAFFE STEPHEN B

IPC: H01J49/00

CPC classification number: G01N33/28 ,  G01N30/7206 ,  G01N2030/8854

Abstract: The present invention is a method to determine the composition of a hydrocarbon feedstream from a small sample of hydrocarbons including the steps analyzing the sample with a combination of chromatograph and mass spectrometer, and reconciling output from step a) with other analytical measurements to determine to determine the composition of the hydrocarbon feedstream.

Abstract translation: 本发明是一种从小型烃类样品中确定烃类进料流的组成的方法，包括用色谱仪和质谱仪的组合分析样品的步骤，以及调节步骤a）的输出与其他分析测量结果，以确定 烃进料流的组成。

公开(公告)号：WO2006130458A3

公开(公告)日：2007-02-08

申请号：PCT/US2006020408

申请日：2006-05-25

Applicant: AMGEN FREMONT INC ,  ASTRAZENECA AB ,  ASTRAZENECA UK LTD ,  GAZIT-BORNSTEIN GADI ,  GREEN LARRY L ,  YANG XIAODONG ,  QUEVA CHRISTOPHE ,  BLAKEY DAVID CHARLES

Inventor： GAZIT-BORNSTEIN GADI ,  GREEN LARRY L ,  YANG XIAODONG ,  QUEVA CHRISTOPHE ,  BLAKEY DAVID CHARLES

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2887 ,  A61K51/1027 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: Antibodies directed to the antigen CD20 and uses of such antibodies are disclosed herein. In particular, fully human monoclonal antibodies directed to the antigen CD20. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3 are disclosed. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also disclosed.

Abstract translation: 本文公开了针对抗原CD20的抗体和这种抗体的用途。 特别是针对抗原CD20的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 被披露。 还公开了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。