发明申请
WO2005116027A3 INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
审中-公开
吲哚酚和吲哚酚衍生物及其作为药物的用途
- 专利标题: INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
- 专利标题(中): 吲哚酚和吲哚酚衍生物及其作为药物的用途
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申请号: PCT/IB2005001513申请日: 2005-05-17
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公开(公告)号: WO2005116027A3公开(公告)日: 2006-04-13
- 发明人: ALLERTON CHARLOTTE MOIRA NORFO , HEPWORTH DAVID , MILLER DUNCAN CHARLES
- 申请人: PFIZER LIMTED , PFIZER , ALLERTON CHARLOTTE MOIRA NORFO , HEPWORTH DAVID , MILLER DUNCAN CHARLES
- 专利权人: PFIZER LIMTED,PFIZER,ALLERTON CHARLOTTE MOIRA NORFO,HEPWORTH DAVID,MILLER DUNCAN CHARLES
- 当前专利权人: PFIZER LIMTED,PFIZER,ALLERTON CHARLOTTE MOIRA NORFO,HEPWORTH DAVID,MILLER DUNCAN CHARLES
- 优先权: GB0411810 2004-05-26; GB0415455 2004-07-09
- 主分类号: A61K31/397
- IPC分类号: A61K31/397 ; A61K31/403 ; A61K31/416 ; A61K31/454 ; A61K31/5377 ; A61P15/00 ; A61P15/10 ; C07D205/04 ; C07D209/34 ; C07D211/10 ; C07D231/56 ; C07D265/30 ; C07D401/04 ; C07D413/04 ; C07D471/04
摘要:
The present invention provides for compounds of formula (I), which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.