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    NEW INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
    2.
    发明申请
    NEW INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS 审中-公开
    新的吲哚酚和吲哚酚衍生物及其作为药物的用途

    公开(公告)号：WO2005116027A2

    公开(公告)日：2005-12-08

    申请号：PCT/IB2005/001513

    申请日：2005-05-17

    申请人： PFIZER LIMTED ,  PFIZER, INC. ,  ALLERTON, Charlotte, Moira, Norfor ,  HEPWORTH, David ,  MILLER, Duncan, Charles

    发明人： ALLERTON, Charlotte, Moira, Norfor ,  HEPWORTH, David ,  MILLER, Duncan, Charles

    IPC分类号： C07D471/04

    CPC分类号： C07D401/04 ,  C07D413/04

    摘要： The present invention provides for compounds of formula (I), which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

    摘要翻译： 本发明提供式（I）化合物，其是一类多巴胺激动剂，更具体地，一类在D3上对D2具有选择性的激动剂。 这些化合物可用于治疗和/或预防性功能障碍，例如女性性功能障碍（FSD），特别是女性性唤醒障碍（FSAD），性欲低下症（HSDD;对性不感兴趣），女性高潮 无效（FOD;无法达到性高潮）; 男性性功能障碍，特别是男性勃起功能障碍（MED）。 本文所提及的男性性功能障碍意在包括射精性疾病，例如早泄，无汗（无法达到性高潮）或期望障碍，如性欲低下症（HSDD;对性不感兴趣）。 这些化合物也可用于治疗神经精神障碍和神经变性疾病。

    CHROMAN COMPOUNDS
    4.
    发明申请
    CHROMAN COMPOUNDS 审中-公开
    色素化合物

    公开(公告)号：WO2006056850A2

    公开(公告)日：2006-06-01

    申请号：PCT/IB2005/003485

    申请日：2005-11-15

    申请人： PFIZER LIMITED ,  PFIZER INC. ,  COOK, Andrew, Simon ,  MILLER, Duncan, Charles

    发明人： COOK, Andrew, Simon ,  MILLER, Duncan, Charles

    IPC分类号： C07D311/58 ,  C07D405/04 ,  C07D413/04 ,  C07D491/04 ,  C07D493/04

    CPC分类号： C07D491/04 ,  C07D311/58 ,  C07D405/04 ,  C07D413/04 ,  C07D493/04

    摘要： PC26133A The present invention provides for compounds of formula (I) wherein A, R 1 , R 2 , R 3 , R 4 and R 5 are defined herein. The compounds of formula (I) are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of neuropsychiatric disorders, neurodegenerative disorders, pain and sexual dysfunction.

    摘要翻译： PC26133A本发明提供式（I）的化合物，其中A，R 1，R 2，R 3，R 4， 和R 5 5在本文中定义。 式（I）的化合物是一类多巴胺激动剂，更特别的是一类在D2上对D3具有选择性的激动剂。 这些化合物可用于治疗和/或预防神经精神障碍，神经变性疾病，疼痛和性功能障碍。

    AMINOPYRIDINE DERIVATIVES AS SELECTIVE DOPAMINE D3 AGONISTS
    6.
    发明申请
    AMINOPYRIDINE DERIVATIVES AS SELECTIVE DOPAMINE D3 AGONISTS 审中-公开
    氨基吡啶衍生物作为选择性多巴胺D3激动剂

    公开(公告)号：WO2005115985A1

    公开(公告)日：2005-12-08

    申请号：PCT/IB2005/001554

    申请日：2005-05-17

    申请人： PFIZER LIMITED ,  PFIZER INC. ,  ALLERTON, Charlotte, Moira, Norfor ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  MILLER, Duncan, Charles

    发明人： ALLERTON, Charlotte, Moira, Norfor ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  MILLER, Duncan, Charles

    IPC分类号： C07D213/73

    CPC分类号： C07D213/73 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04

    摘要： The present invention provides for compounds of formula (I) which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

    摘要翻译： 本发明提供了作为一类多巴胺激动剂的式（I）化合物，更具体地，一类在D3上对D2有选择性的一类激动剂。 这些化合物可用于治疗和/或预防性功能障碍，例如女性性功能障碍（FSD），特别是女性性唤醒障碍（FSAD），性欲低下症（HSDD;对性不感兴趣），女性高潮 无效（FOD;无法达到性高潮）; 男性性功能障碍，特别是男性勃起功能障碍（MED）。 本文所提及的男性性功能障碍意在包括射精性疾病，例如早泄，无汗（无法达到性高潮）或期望障碍，如性欲低下症（HSDD;对性不感兴趣）。 这些化合物也可用于治疗神经精神障碍和神经变性疾病。

    INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
    8.
    发明申请
    INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS 审中-公开
    吲哚酚和吲哚酚衍生物及其作为药物的用途

    公开(公告)号：WO2005116027A3

    公开(公告)日：2006-04-13

    申请号：PCT/IB2005001513

    申请日：2005-05-17

    申请人： PFIZER LIMTED ,  PFIZER ,  ALLERTON CHARLOTTE MOIRA NORFO ,  HEPWORTH DAVID ,  MILLER DUNCAN CHARLES

    发明人： ALLERTON CHARLOTTE MOIRA NORFO ,  HEPWORTH DAVID ,  MILLER DUNCAN CHARLES

    IPC分类号： A61K31/397 ,  A61K31/403 ,  A61K31/416 ,  A61K31/454 ,  A61K31/5377 ,  A61P15/00 ,  A61P15/10 ,  C07D205/04 ,  C07D209/34 ,  C07D211/10 ,  C07D231/56 ,  C07D265/30 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04

    CPC分类号： C07D401/04 ,  C07D413/04

    摘要： The present invention provides for compounds of formula (I), which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

    摘要翻译： 本发明提供式（I）化合物，其是一类多巴胺激动剂，更具体地，一类在D3上对D2具有选择性的激动剂。 这些化合物可用于治疗和/或预防性功能障碍，例如女性性功能障碍（FSD），特别是女性性唤起障碍（FSAD），性欲低下症（HSDD;对性不感兴趣），女性高潮 无效（FOD;无法达到性高潮）; 男性性功能障碍，特别是男性勃起功能障碍（MED）。 本文所提及的男性性功能障碍意在包括射精性疾病，例如早泄，无汗（无法达到性高潮）或期望障碍，如性欲低下症（HSDD;对性不感兴趣）。 这些化合物也可用于治疗神经精神障碍和神经变性疾病。