Invention Application
- Patent Title: CHEMICALLY DERIVATIZED CD4 AND USES THEREOF
- Patent Title (中): 化学衍生的CD4及其用途
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Application No.: PCT/US2006047907Application Date: 2006-12-14
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Publication No.: WO2007075414A3Publication Date: 2008-11-20
- Inventor: HENDRICKSON WAYNE A , XIE HUI , SMITH AMOS B , NG DANNY
- Applicant: UNIV COLUMBIA , UNIV PENNSYLVANIA , HENDRICKSON WAYNE A , XIE HUI , SMITH AMOS B , NG DANNY
- Assignee: UNIV COLUMBIA,UNIV PENNSYLVANIA,HENDRICKSON WAYNE A,XIE HUI,SMITH AMOS B,NG DANNY
- Current Assignee: UNIV COLUMBIA,UNIV PENNSYLVANIA,HENDRICKSON WAYNE A,XIE HUI,SMITH AMOS B,NG DANNY
- Priority: US75046405 2005-12-14; US78946706 2006-04-04
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00 ; C07K17/00 ; G01N31/00
Abstract:
This invention provides two soluble polypeptides which comprise a portion of CD4 comprising all HIV gpl20-binding epitopes present on intact CD4, wherein the polypeptide has a cysteine substitution at a residue which, in intact CD4, interfaces with HIV gpl20. This invention provides also provides a method for making a derivatized soluble polypeptide and a method for obtaining a structural model useful in the design of an agent for inhibiting CD4 binding to HIV gpl20.
Information query
