公开(公告)号：WO2007103832A3

公开(公告)日：2007-09-13

申请号：PCT/US2007/063241

申请日：2007-03-02

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  BAUGHMAN, Ray, H. ,  EBRON, Von, Howard ,  YANG, Zhiwei ,  SEYER, Daniel, J. ,  KOZLOV, Mikhail ,  OH, Jiyoung ,  XIE, Hui ,  RAZAL, Joselito ,  FERRARIS, John, P. ,  MACDIARMID, Alan, G. (deceased) ,  MACAULAY, William, Alexander

Inventor： BAUGHMAN, Ray, H. ,  EBRON, Von, Howard ,  YANG, Zhiwei ,  SEYER, Daniel, J. ,  KOZLOV, Mikhail ,  OH, Jiyoung ,  XIE, Hui ,  RAZAL, Joselito ,  FERRARIS, John, P. ,  MACDIARMID, Alan, G. (deceased) ,  MACAULAY, William, Alexander

IPC: F02C1/00 ,  H01M8/10 ,  C22F1/00

Abstract: Fuel-powered actuators are described wherein actuation is a consequence of electrochemical processes, chemical processes, or combinations thereof. These fuel-powered actuators include artificial muscles and actuators in which actuation is non-mechanical. The actuators range from large actuators to microscopic and nanoscale devices.

公开(公告)号：WO2007103832A2

公开(公告)日：2007-09-13

申请号：PCT/US2007063241

申请日：2007-03-02

Applicant: UNIV TEXAS ,  BAUGHMAN RAY H ,  EBRON VON HOWARD ,  YANG ZHIWEI ,  SEYER DANIEL J ,  KOZLOV MIKHAIL ,  OH JIYOUNG ,  XIE HUI ,  RAZAL JOSELITO ,  FERRARIS JOHN P ,  MACDIARMID ALAN G ,  MACAULAY WILLIAM ALEXANDER

Inventor： BAUGHMAN RAY H ,  EBRON VON HOWARD ,  YANG ZHIWEI ,  SEYER DANIEL J ,  KOZLOV MIKHAIL ,  OH JIYOUNG ,  XIE HUI ,  RAZAL JOSELITO ,  FERRARIS JOHN P ,  MACDIARMID ALAN G ,  MACAULAY WILLIAM ALEXANDER

IPC: F02B15/00

CPC classification number: F03G7/005 ,  F03G7/065 ,  H02N11/006

Abstract: Fuel-powered actuators are described wherein actuation is a consequence of electrochemical processes, chemical processes, or combinations thereof. These fuel-powered actuators include artificial muscles and actuators in which actuation is non-mechanical. The actuators range from large actuators to microscopic and nanoscale devices.

Abstract translation: 描述了燃料驱动的致动器，其中致动是电化学过程，化学过程或其组合的结果。 这些燃料供给致动器包括人造肌肉和致动器，其中致动是非机械的。 致动器范围从大型执行机构到微观和纳米级设备。

公开(公告)号：WO2011050105A1

公开(公告)日：2011-04-28

申请号：PCT/US2010/053436

申请日：2010-10-20

Applicant: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE ,  SMITH, Jeff ,  XIE, Hui

Inventor： SMITH, Jeff ,  XIE, Hui

IPC: B01F3/08 ,  B82B1/00

CPC classification number: A61K47/30 ,  A61K9/5153 ,  A61K9/5192 ,  A61K31/00 ,  A61K31/337 ,  A61K31/704 ,  A61K45/06 ,  A61K47/34 ,  B01F3/0807 ,  B01F5/0471 ,  B01F5/0475 ,  B01F5/048 ,  B01F13/0059 ,  B82Y5/00 ,  A61K2300/00

Abstract: Disclosed herein are compositions of nanoparticles. In some embodiments, the nanoparticles are Janus particles, where each particle includes a first component and second component that are exposed to the surface of the particle. Also, disclosed are methods and systems for making a composition of nanoparticles. Finally, a method of treating a mammal by administering a composition of nanoparticles is disclosed.

Abstract translation: 本文公开了纳米颗粒的组合物。 在一些实施方案中，纳米颗粒是Janus颗粒，其中每个颗粒包括暴露于颗粒表面的第一组分和第二组分。 还公开了制备纳米颗粒组合物的方法和系统。 最后，公开了一种通过施用纳米颗粒组合物来治疗哺乳动物的方法。

公开(公告)号：WO2007075414A2

公开(公告)日：2007-07-05

申请号：PCT/US2006/047907

申请日：2006-12-14

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  HENDRICKSON, Wayne, A. ,  XIE, Hui ,  SMITH, Amos, B. ,  NG, Danny

Inventor： HENDRICKSON, Wayne, A. ,  XIE, Hui ,  SMITH, Amos, B. ,  NG, Danny

IPC: C07K16/10 ,  A61K39/42

CPC classification number: C07K14/70514

Abstract: This invention provides two soluble polypeptides which comprise a portion of CD4 comprising all HIV gpl20-binding epitopes present on intact CD4, wherein the polypeptide has a cysteine substitution at a residue which, in intact CD4, interfaces with HIV gpl20. This invention provides also provides a method for making a derivatized soluble polypeptide and a method for obtaining a structural model useful in the design of an agent for inhibiting CD4 binding to HIV gpl20.

Abstract translation: 本发明提供两种可溶性多肽，其包含一部分CD4，其包含存在于完整CD4上的所有HIV gp120结合表位，其中该多肽在完整的CD4与HIV gp120的界面处具有半胱氨酸置换。 本发明还提供了制备衍生化可溶性多肽的方法和获得用于设计用于抑制CD4结合HIV gp120的药剂的结构模型的方法。

公开(公告)号：WO2007075414A3

公开(公告)日：2008-11-20

申请号：PCT/US2006047907

申请日：2006-12-14

Applicant: UNIV COLUMBIA ,  UNIV PENNSYLVANIA ,  HENDRICKSON WAYNE A ,  XIE HUI ,  SMITH AMOS B ,  NG DANNY

Inventor： HENDRICKSON WAYNE A ,  XIE HUI ,  SMITH AMOS B ,  NG DANNY

IPC: C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  G01N31/00

CPC classification number: C07K14/70514

Abstract: This invention provides two soluble polypeptides which comprise a portion of CD4 comprising all HIV gpl20-binding epitopes present on intact CD4, wherein the polypeptide has a cysteine substitution at a residue which, in intact CD4, interfaces with HIV gpl20. This invention provides also provides a method for making a derivatized soluble polypeptide and a method for obtaining a structural model useful in the design of an agent for inhibiting CD4 binding to HIV gpl20.

Abstract translation: 本发明提供两种可溶性多肽，其包含一部分CD4，其包含存在于完整CD4上的所有HIV gp120结合表位，其中该多肽在完整的CD4与HIV gp120的界面处具有半胱氨酸置换。 本发明还提供了制备衍生化可溶性多肽的方法和获得用于设计用于抑制CD4结合HIV gp120的药剂的结构模型的方法。