Invention Application
WO2012083953A1 INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
审中-公开
INGENOL-3-ACYLATES III和INGENOL-3-CARBAMATES
- Patent Title: INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
- Patent Title (中): INGENOL-3-ACYLATES III和INGENOL-3-CARBAMATES
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Application No.: PCT/DK2011/000154Application Date: 2011-12-22
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Publication No.: WO2012083953A1Publication Date: 2012-06-28
- Inventor: GRUE-SØRENSEN, Gunnar , LIANG, Xifu , HÖGBERG, Thomas , MÅNSSON, Kristoffer , VEDSØ, Per , VIFIAN, Thomas
- Applicant: LEO PHARMA A/S , GRUE-SØRENSEN, Gunnar , LIANG, Xifu , HÖGBERG, Thomas , MÅNSSON, Kristoffer , VEDSØ, Per , VIFIAN, Thomas
- Applicant Address: Industriparken 55 DK-2750 Ballerup DK
- Assignee: LEO PHARMA A/S,GRUE-SØRENSEN, Gunnar,LIANG, Xifu,HÖGBERG, Thomas,MÅNSSON, Kristoffer,VEDSØ, Per,VIFIAN, Thomas
- Current Assignee: LEO PHARMA A/S,GRUE-SØRENSEN, Gunnar,LIANG, Xifu,HÖGBERG, Thomas,MÅNSSON, Kristoffer,VEDSØ, Per,VIFIAN, Thomas
- Current Assignee Address: Industriparken 55 DK-2750 Ballerup DK
- Agency: HORNEMAN, Anne Marie
- Priority: US61/426,378 20101222; US61/448,350 20110302; US61/534,055 20110913
- Main IPC: C07C271/34
- IPC: C07C271/34 ; C07C249/06 ; C07D261/18 ; C07D277/32 ; C07D309/08 ; C07D333/38 ; C07D401/04 ; C07D295/21 ; A61K31/27 ; A61K31/215 ; A61P35/00 ; A61K31/381 ; A61K31/4192 ; A61K31/42 ; A61K31/426
Abstract:
The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is -NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
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