Invention Application
- Patent Title: TRIAZOLE AGONISTS OF THE APJ RECEPTOR
- Patent Title (中): APJ受体的三唑激动剂
-
Application No.: PCT/US2016/033088Application Date: 2016-05-18
-
Publication No.: WO2016187308A1Publication Date: 2016-11-24
- Inventor: CHEN, Ning , CHEN, Xiaoqi , CHEN, Yinhong , CHENG, Alan C. , CONNORS, Richard V. , DEIGNAN, Jeffrey , DRANSFIELD, Paul John , DU, Xiaohui , FU, Zice , HEATH, Julie Anne , HORNE, Daniel B. , HOUZE, Jonathan , KALLER, Matthew R. , KHAKOO, Aarif Yusuf , KOPECKY, David John , LAI, Su-Jen , MA, Zhihua , MCGEE, Lawrence R. , MEDINA, Julio C. , MIHALIC, Jeffrey T. , NISHIMURA, Nobuko , OLSON, Steven H. , PATTAROPONG, Vatee , SWAMINATH, Gayathri , WANG, Xiaodong , YANG, Kevin , YEH, Wen-Chen , DEBENEDETTO, Mikkel V. , FARRELL, Robert P. , HEDLEY, Simon J. , JUDD, Ted C. , KAYSER, Frank
- Applicant: AMGEN INC.
- Applicant Address: One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- Agency: FRIEDRICHSEN, Bernard P.
- Priority: US62/164,106 20150520
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D401/04 ; C07D413/04 ; A61K31/4196 ; A61K31/4439 ; A61P9/00
Abstract:
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures where the definitions of the variables are provided herein.
Information query
