Invention Application
WO2017070337A1 METHODS FOR DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO IMMUNE CELLS
审中-公开
多向性干细胞直接分化为免疫细胞的方法
- Patent Title: METHODS FOR DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO IMMUNE CELLS
- Patent Title (中): 多向性干细胞直接分化为免疫细胞的方法
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Application No.: PCT/US2016/057899Application Date: 2016-10-20
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Publication No.: WO2017070337A1Publication Date: 2017-04-27
- Inventor: VODYANYK, Maksym, A. , ZHANG, Xin , BRANDL, Andrew, J. , RAJESH, Deepika , SWANSON, Bradley , MUNN, Christie , BURTON, Sarah, A. , WANG, Wen, Bo
- Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.
- Applicant Address: 525 Science Drive, Suite 200 Madison, WI 53711 US
- Assignee: CELLULAR DYNAMICS INTERNATIONAL, INC.
- Current Assignee: CELLULAR DYNAMICS INTERNATIONAL, INC.
- Current Assignee Address: 525 Science Drive, Suite 200 Madison, WI 53711 US
- Agency: PARKER, David, L.
- Priority: US62/244,101 20151020; US62/404,470 20161005
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; C12N5/0784 ; C12N5/0789
Abstract:
Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.
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