Invention Application
- Patent Title: DUAL MODULATORS OF FARNESOID X RECEPTOR AND SOLUBLE EPOXIDE HYDROLASE
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Application No.: PCT/EP2017/062692Application Date: 2017-05-24
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Publication No.: WO2018215070A1Publication Date: 2018-11-29
- Inventor: MERK, Daniel , SCHMIDT, Jurema , PROSCHAK, Ewgenij , SCHUBERT-ZSILAVECZ, Manfred
- Applicant: JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN
- Applicant Address: Theodor-W.-Adorno-Platz 1 60323 Frankfurt am Main DE
- Assignee: JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN
- Current Assignee: JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN
- Current Assignee Address: Theodor-W.-Adorno-Platz 1 60323 Frankfurt am Main DE
- Agency: KUTTENKEULER, David
- Main IPC: A61K31/192
- IPC: A61K31/192 ; C07C255/60 ; C07C311/08 ; C07C311/46 ; C07C311/51 ; C07C317/32 ; C07C321/28 ; C07D257/04 ; C07C233/73 ; C07C233/76 ; C07C233/78 ; C07C233/87 ; C07C235/52 ; C07C237/30 ; C07C237/36 ; A61P3/06 ; A61K31/166 ; A61K31/18 ; A61K31/277 ; A61K31/41
Abstract:
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR and inhibitors (antagonists) of sEH. The invention also provides methods for treating subjects suffering from diseases associated with FXR and sEH, such as metabolic disorders, in particular non-alcoholic fatty liver or non-alcoholic steatohepatitis (NASH).
Information query
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