Invention Application
- Patent Title: METHODS FOR SCARLESS INTRODUCTION OF TARGETED MODIFICATIONS INTO TARGETING VECTORS
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Application No.: PCT/US2020/026405Application Date: 2020-04-02
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Publication No.: WO2020206134A1Publication Date: 2020-10-08
- Inventor: BRYDGES, Susannah , ROJAS, Jose F. , WARSHAW, Gregg S. , SIAO, Chia-Jen
- Applicant: REGENERON PHARMACEUTICALS, INC.
- Applicant Address: 777 Old Saw Mill River Road Tarrytown, New York 10591 US
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: 777 Old Saw Mill River Road Tarrytown, New York 10591 US
- Agency: SCHILLING, Stephen H. et al.
- Priority: US62/829,327 20190404
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C12N15/64
Abstract:
Methods for introducing a scarless targeted genetic modification into a preexisting targeting vector are provided. The methods can use combinations of bacterial homologous recombination (BHR) and in vitro assembly to introduce such targeted genetic modifications into a preexisting targeting vector in a scarless manner.
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