The invention relates to a disc brake (1), in particular for a motor vehicle, comprising a brake caliper (3) that has a clamping section (3a), which is equipped with a clamping device with a brake rotary lever (11), at least two threaded pistons (7, 8), an adjustment device (9), and a driver device (10), and comprising a synchronization mechanism (12) for synchronizing the rotational movements of the threaded pistons (7, 8), wherein the synchronization mechanism (12) is arranged outside of the housing of the brake caliper (3) within a sealed cover (21) on the clamping section (3a) of the brake caliper (3), and the synchronization mechanism (12) has at least one synchronizing element (13) and two synchronizing wheels (14, 15), a first synchronizing wheel (14) of which is coupled to one threaded piston (7) and a second synchronizing wheel (15) of which is coupled to the other threaded piston (8). The synchronization mechanism (12) is arranged on the clamping section (3a) of the brake caliper (3) so as to be guided about a lever housing (3c) of the brake rotary lever (11), said lever housing protruding from the clamping section (3a) of the brake caliper (3).