公开(公告)号：EP1966603A4

公开(公告)日：2009-08-19

申请号：EP06840418

申请日：2006-12-29

申请人： BIO LAYER PTY LTD

发明人： MAEJI JOE NOBUYOSHI ,  GORSE ALAIN-DOMINIQUE JEAN-PIE ,  MONTEIRO RAISA LEONIDOVNA

IPC分类号： G01N33/53 ,  C40B50/18 ,  G01N33/543 ,  G01N33/68

CPC分类号： G01N33/54393

摘要： A method of binding a target molecule from an analyte containing the target molecule in admixture with at least one non-target molecule, which method comprises exposing the analyte to a substrate comprising first and second surface binding components, wherein the first surface binding component has specific binding affinity with respect to the target molecule but is independently unable to provide effective binding of the target molecule to the substrate, wherein the second surface binding component has non-specific binding affinity with respect to the target molecule and is independently unable to provide effective specific binding of the target molecule to the substrate, and wherein the target molecule is immobilized on the substrate by the combined binding effect of the first and second surface binding components.

公开(公告)号：EP1773866A4

公开(公告)日：2009-04-01

申请号：EP05756657

申请日：2005-06-30

申请人： BIO LAYER PTY LTD

发明人： MUIR BENJAMIN WARD ,  BARDEN MICHAEL C ,  RYLATT DENNIS BRIAN ,  MAEJI N JOE ,  HILLYARD CARMEL JUDITH ,  GORSE ALAIN-DOMINIQUE JEAN-PIERRE ,  MONTEIRO RAISA LEONIDOVNA

IPC分类号： C07K1/22 ,  C07K17/06 ,  G01N33/543 ,  G01N33/547 ,  G01N33/553

CPC分类号： G01N33/553 ,  C07K17/06 ,  G01N33/54353 ,  G01N33/54393

摘要： A method of immobilising a target molecule on a substrate, which comprises exposing the target molecule to the substrate in the presence of a metal complex, wherein the target molecule is an unmodified target molecule, and wherein the metal complex is selected to provide a stable binding interaction between the target molecule and the substrate.

公开(公告)号：EP1358255A4

公开(公告)日：2004-11-10

申请号：EP01271412

申请日：2001-12-19

申请人： BIO LAYER PTY LTD

发明人： STENZEL-ROSENBAUM MARTINA HEID ,  DAVIS THOMAS

IPC分类号： C08F293/00 ,  C08J5/18 ,  C08J9/28

CPC分类号： C08J5/18 ,  C08F293/005 ,  C08F2438/01

摘要： This invention relates to porous polymer films and methods for their preparation. In particular the present invention relates to a method for preparing porous polymer films using ATRP or RAFT polymerisation, or using graft polymers prepared by living/controlled polymerisation or using microgels, methods for enhancing the uniformity of pore size in porous polymer films or for preparing porous polymer films having regularly spaced pores of substantially regular pore size, and methods for facilitating the casting of porous polymer films or for controlling or increasing the pore size of porous polymer films.

公开(公告)号：EP2569338A4

公开(公告)日：2014-01-08

申请号：EP11779968

申请日：2011-05-10

申请人： BIO LAYER PTY LTD

发明人： MAEJI NOBUYOSHI JOE ,  YANG LIQUN ,  ABERNETHY NEVIN JOHN ,  FONTANELLE BARBARA TENGATEN ,  SAVVINA OLYA AALIYAH

IPC分类号： C07K17/14

CPC分类号： G01N33/54353 ,  C07K17/14

公开(公告)号：EP1700244A4

公开(公告)日：2009-07-08

申请号：EP04802049

申请日：2004-12-10

申请人： BIO LAYER PTY LTD

发明人： GORSE ALAIN-DOMINIQUE JEAN-PIERRE

IPC分类号： C07K1/22 ,  C07K17/02 ,  C07K17/06 ,  G01N33/543 ,  G01N33/68 ,  G06F19/00 ,  G06F19/16 ,  G06F19/18

CPC分类号： C07K1/22 ,  C07K17/02 ,  C07K17/06 ,  C07K2299/00 ,  G01N33/6803 ,  G01N33/6854 ,  G06F19/16 ,  G06F19/18 ,  G06F19/706

摘要： A method of producing a binding surface for a target molecule having a functional binding site, which method comprises: (i) identifying within the target molecule an anchor site which is remote from the functional binding site; (ii) generating a pharmacophore model for the anchor site; (iii) using the pharmacophore model to identify an anchor site binding ligand; and (iv) providing the anchor site binding ligand on a surface of a substrate such that the ability of the anchor site binding ligand to bind to the anchor site is preserved.

公开(公告)号：EP1383828A4

公开(公告)日：2006-10-04

申请号：EP02712637

申请日：2002-03-28

申请人： BIO LAYER PTY LTD

发明人： KAMBOURIS PETER ,  WHITTAKER MICHAEL ,  DAVIS TOM ,  BLAKEY IDRISS ,  DAY GARY

IPC分类号： C08F2/00 ,  C08F8/00 ,  C08F255/00 ,  C08F259/08 ,  C08F265/04 ,  C08F287/00 ,  C08F291/00 ,  C08F293/00 ,  C08J7/12 ,  C08J7/16 ,  B29C71/04 ,  C08F8/30 ,  C08F8/34 ,  C08F255/02 ,  C08J7/18 ,  C08J9/224 ,  C08J9/36

CPC分类号： C08J7/16 ,  C08F8/00 ,  C08F255/00 ,  C08F259/08 ,  C08F265/04 ,  C08F287/00 ,  C08F291/00 ,  C08F293/005 ,  C08F2438/01 ,  C08F2438/02 ,  C08J7/12 ,  Y10T428/31511 ,  Y10T428/31663 ,  C08F10/00

摘要： The present invention provides improved methods for conducting living/controlled polymerization on polymeric solid supports. The improved methods allow polymerization to occur directly from the non-functionalized surface of a bulk support. In addition, polymerization may be re-initiated to provide co-polymers. The disclosed methods may employ the non-nitroxide-based RAFT and ATRP control agents that allow controlled polymerization to proceed at relatively low temperatures (

公开(公告)号：EP1534755A4

公开(公告)日：2005-08-17

申请号：EP03718551

申请日：2003-05-09

申请人： BIO LAYER PTY LTD

发明人： BARDEN MICHAEL C ,  KAMBOURIS PETER A

IPC分类号： C07K17/02 ,  C07K17/06 ,  C09D135/06 ,  G01N33/547

CPC分类号： B01D61/18 ,  B01D67/0093 ,  B01D69/02 ,  B01D71/34 ,  B01D2323/38 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/0072 ,  B01J2219/00736 ,  C07K17/02 ,  C08F259/08 ,  C08F261/06 ,  C08F291/00 ,  C08F293/005 ,  C08L51/003 ,  C08L53/00 ,  C09D151/003 ,  C09D153/00 ,  C40B40/04 ,  C40B50/14 ,  C40B50/18 ,  C08L2666/02

摘要： The present invention relates to a surface discovery system comprising chemical compositions and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. This surface discovery platform is built upon a fundamental chemical unit referred to as a synthon. Each synthon comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a passive (P) constituent and an active (A) constituent; a spacer unit (S) separating the backbone from a functional group; and a functional group (F). Variation of these synthon elements allows generation of large libraries surface coatings with a broad range of molecular and macroscopic properties. Further the spectrum of surfaces provided by the invention permits optimization of the wide range of solid-phase applications that involve surface immobilization of molecules.

摘要翻译： 本发明涉及一种表面发现系统，其包括用于在固体基底上产生大量不同表面涂层的化学组合物和高产量组合合成方法。 这个表面发现平台建立在一个称为合成器的基本化学单元上。 每种合成子包含至少三种元素：固体基质上的包含被动（P）组分和活性（A）组分的化学主链涂层; 间隔单元（S），其将骨架与官能团分开; 和功能组（F）。 这些合成元素的变化允许产生具有广泛分子和宏观性质的大型文库表面涂层。 此外，由本发明提供的表面谱允许优化涉及表面固定分子的宽范围的固相应用。