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    LIGHT-ACTIVATED TWO-COMPONENT PROTEIN BINDING MATRIX
    5.
    发明公开
    LIGHT-ACTIVATED TWO-COMPONENT PROTEIN BINDING MATRIX 审中-公开
    活化的双组分蛋白质结合基质

    公开(公告)号：EP3224260A1

    公开(公告)日：2017-10-04

    申请号：EP15854188.8

    申请日：2015-10-29

    Applicant: National University of Singapore

    Inventor： DRUM, Chester Lee

    IPC: C07D491/107 ,  C07D209/12 ,  C07D209/18 ,  C07K1/22 ,  C07K7/06 ,  C07K7/08 ,  G01N33/547

    CPC classification number: C07D209/12 ,  C07D209/18 ,  C07D491/107 ,  C07K1/22 ,  C07K7/06 ,  C07K7/08 ,  G01N33/547

    Abstract: A binding pair for chromatographic separation or purification of a molecule of interest, where one binding member of the pair is an isomerizable organic molecule and the other binding member of the pair is an isomer-specific affinity agent bound to a molecule of interest. The binding pair associates and disassociates upon exposure to a binding agent, such as using light, decreased intensity of light, darkness, heat, stress, ions, an isomerizable affinity agent, change in pH, or a combination thereof.

    Abstract translation: 用于色谱分离或纯化目标分子的结合对，其中对中的一个结合成员是可异构化的有机分子，并且该对中的另一个结合成员是与目标分子结合的异构体特异性亲和试剂。 当暴露于结合剂时，例如使用光，降低的光强度，黑暗度，热量，应激，离子，可异构亲和剂，pH变化或其组合，结合对结合并解离。

    CHAPERONE INTERACTION ASSAYS AND USES THEREOF
    8.
    发明公开
    CHAPERONE INTERACTION ASSAYS AND USES THEREOF 审中-公开
    安东尼·达文的CHAPERON-INTERAKTIONSASSAY

    公开(公告)号：EP2707714A1

    公开(公告)日：2014-03-19

    申请号：EP12782991.9

    申请日：2012-05-09

    Applicant: Whitehead Institute For Biomedical Research

    Inventor： TAIPALE, Mikko ,  LINDQUIST, Susan

    IPC: G01N33/53 ,  G01N33/547 ,  G01N33/543 ,  G01N33/487

    CPC classification number: G01N33/573 ,  C12Q1/485 ,  C12Q1/66 ,  G01N33/502 ,  G01N33/54306 ,  G01N33/57484 ,  G01N33/6845 ,  G01N33/6872 ,  G01N2500/02 ,  G01N2800/60

    Abstract: In some aspects, the invention provides methods of identifying, detecting, and/or measuring protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein activity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some aspects, the invention provides methods for identifying and/or characterizing compounds and/or for assessing compound specificity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some embodiments, a client protein is a kinase. In some embodiments, a compound is a kinase inhibitor. In some aspects, the invention provides methods of profiling kinase inhibitor specificity. In some aspects, the invention provides assay systems and/or reagents useful for performing one or more of the inventive methods. In some aspects, the invention provides newly identified targets of a variety of kinase inhibitors. In some aspect, the invention provides methods of inhibiting kinases identified herein as targets of certain kinase inhibitors. In some aspects, the invention provides methods of treating a disease, e.g., cancer, by inhibiting one or more kinase(s) newly identified as targets of certain kinase inhibitors.

    Abstract translation: 在一些方面，本发明提供鉴定，检测和/或测量蛋白质 - 蛋白质相互作用的方法。 在一些方面，本发明提供鉴定和/或表征蛋白质 - 蛋白质相互作用的调节剂的方法。 在一些方面，本发明提供鉴定和/或表征蛋白质活性调节剂的方法，其中所述方法至少部分地基于测量分子伴侣和客体蛋白质之间的相互作用。 在一些方面，本发明提供用于鉴定和/或表征化合物和/或用于评估化合物特异性的方法，其中所述方法至少部分地基于测量分子伴侣和客体蛋白质之间的相互作用。 在一些实施方案中，客户蛋白质是激酶。 在一些实施方案中，化合物是激酶抑制剂。 在一些方面，本发明提供了分析激酶抑制剂特异性的方法。 在一些方面，本发明提供了用于执行本发明一种或多种方法的测定系统和/或试剂。 在一些方面，本发明提供了新鉴定的各种激酶抑制剂的靶标。 在一些方面，本发明提供抑制本文鉴定的激酶作为某些激酶抑制剂靶标的方法。 在一些方面，本发明提供了通过抑制新鉴定为某些激酶抑制剂的靶标的一种或多种激酶来治疗疾病例如癌症的方法。

    IMMOBILIZATION SUBSTRATE AND METHOD FOR PRODUCING THE SAME
    10.
    发明公开
    IMMOBILIZATION SUBSTRATE AND METHOD FOR PRODUCING THE SAME 有权
    固定化及其制造方法

    公开(公告)号：EP2359138A1

    公开(公告)日：2011-08-24

    申请号：EP09830496.7

    申请日：2009-12-04

    Applicant: FUJIFILM Corporation ,  The University of Tokyo

    Inventor： MINAMI, Koichi ,  TSUZUKI, Hirohiko ,  UEDA, Hiroshi ,  IHARA, Masaki

    IPC: G01N33/543 ,  C07K19/00 ,  G01N33/547

    CPC classification number: G01N33/54353

    Abstract: An antibody-fragment-immobilizing substrate includes a substrate and at least one set of antibody fragments, wherein antibody fragments of each set include at least two types of separate antibody fragments, the at least two types of separate antibody fragments include at least one type of labeled antibody fragment having a labeled site labeled with a luminescent substance and at least one type of acceptor antibody fragment having an acceptor site for accepting emission from the labeled antibody fragment, and the at least one type of labeled antibody fragment and the at least one type of acceptor antibody fragment are capable of cooperatively recognizing one type of antigen in combination and are independently immobilized on the substrate in a positional relationship that allows each of the antibody fragments in one set to bind to the same antigen.

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