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1.发明授权COMBINATION OF A PROGESTATIONAL AGENT AND A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR FOR THE TREATMENT OF PREECLAMPSIA AND PRETERM LABOR 失效组合物先兆子痫和早期出生到PROGESTATIVES剂处理和氮氧化物合酶衬底和/或供体CONTAINS
公开(公告)号：EP0708647B1
公开(公告)日：2000-05-10
申请号：EP94924261.4
申请日：1994-07-18
IPC分类号： A61K31/57
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/341 , A61K31/57 , A61K31/60 , Y10S514/841 , Y10S514/843 , Y10S514/866 , Y10S514/903 , A61K31/557 , A61K31/34 , A61K31/26 , A61K31/21 , A61K2300/00
摘要： Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI2-mimetic, a thromboxane (TXA2) inhibitor, a compound possessing TXA2-agonistic and TXA2-inhibiting properties, a compound possessing TXA2-antagonistic and PGI2-memetic activities, and a TXA2 antagonist.
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2.发明公开TREATMENT OF UTERINE CONTRACTILITY DISORDERS WITH A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR, OR A NITRIC OXIDE INHIBITOR 失效处理与及其一氧化氮合酶底物和/或捐助，或STICKSTOFFOXIDHEMMER子宫收缩的申诉
公开(公告)号：EP0730448A1
公开(公告)日：1996-09-11
申请号：EP95900759.0
申请日：1994-11-17
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/557 , A61K31/57 , A61K38/11 , A61K31/41 , A61K31/34 , A61K31/295 , A61K31/21 , A61K2300/00
摘要： Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in combination with one or more of a prostaglandin inhibitor, a prostacyclin-mimetic, a progestin, an oxytocin antagonist or a β-agonist in an amount effective to ameliorate the symptoms thereof; and inadequate menses treated and induction of abortion or stimulation of labor in a pregnant female is achieved by uterine contractility stimulation by administering thereto a nitric oxide inhibitor, either alone or in a combination of progesterone antagonist, an oxytocin or oxytocin analogue antagonist or prostaglandin.
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3.发明公开COMBINATION OF A PROGESTATIONAL AGENT AND A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR FOR THE TREATMENT OF PREECLAMPSIA AND PRETERM LABOR 失效组合物先兆子痫和早期出生到PROGESTATIVES剂处理和氮氧化物合酶衬底和/或供体CONTAINS
公开(公告)号：EP0708647A1
公开(公告)日：1996-05-01
申请号：EP94924261.0
申请日：1994-07-18
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/341 , A61K31/57 , A61K31/60 , Y10S514/841 , Y10S514/843 , Y10S514/866 , Y10S514/903 , A61K31/557 , A61K31/34 , A61K31/26 , A61K31/21 , A61K2300/00
摘要： Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI2-mimetic, a thromboxane (TXA2) inhibitor, a compound possessing TXA2-agonistic and TXA2-inhibiting properties, a compound possessing TXA2-antagonistic and PGI2-memetic activities, and a TXA2 antagonist.
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4.发明授权USE OF NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR, OR A NITRIC OXIDE INHIBITOR FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF UTERINE CONTRACTILITY DISORDERS 失效一氧化氮合酶基材和/或或捐助STICKSTOFFOXIDHEMMER的药品生产用于病症子宫活动的处理
公开(公告)号：EP0730448B1
公开(公告)日：2002-02-06
申请号：EP95900759.2
申请日：1994-11-17
IPC分类号： A61K31/195 , A61K31/04
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/557 , A61K31/57 , A61K38/11 , A61K31/41 , A61K31/34 , A61K31/295 , A61K31/21 , A61K2300/00
摘要： Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in combination with one or more of a prostaglandin inhibitor, a prostacyclin-mimetic, a progestin, an oxytocin antagonist or a β-agonist in an amount effective to ameliorate the symptoms thereof; and inadequate menses treated and induction of abortion or stimulation of labor in a pregnant female is achieved by uterine contractility stimulation by administering thereto a nitric oxide inhibitor, either alone or in a combination of progesterone antagonist, an oxytocin or oxytocin analogue antagonist or prostaglandin.
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5.发明公开ENDOTHELIN ANTAGONISTS AND ENDOTHELIN SYNTHASE INHIBITORS FOR THE PREVENTION AND TREATMENT OF UTERINE CONTRACTILITY DISORDERS, PREECLAMPSIA, ATHEROSCLEROTIC VASCULAR DISEASE, HYPERTENSION AND FOR HORMONE REPLACEMENT THERAPY 失效为防止及治疗投诉内皮素拮抗剂和内皮素合酶抑制剂REGARDING THE子宫动脉粥样硬化的先兆子痫GEFA疾病和高血压用于激素替代疗法
公开(公告)号：EP0844884A2
公开(公告)日：1998-06-03
申请号：EP95940801.0
申请日：1995-11-30
CPC分类号： A61K45/06 , A61K31/00 , A61K31/223 , A61K31/42 , A61K31/565 , A61K31/57 , A61K31/60 , A61K38/12 , Y10S514/899 , A61K2300/00
摘要： A pharmaceutical composition for and methods of treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal, treatment of atherosclerotic vascular disease and hypertension in males as well as females, and for hormone replacement therapy in peri- and post-menopausal females, comprising administering effective amounts of an endothelin antagonist and/or an endothelin synthase inhibitor or both, in combination with (a) a progestin, and/or and estrogen, and/or (b) a cyclooxygenase inhibitor, and/or (c) a nitric oxide donor and/or nitric substrate, to prevent and/or ameliorate said conditions, are disclosed. In the method aspects, the endothelin antagonist and/or endothelin synthase inhibitor can be administered alone for treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a pregnant female mammal. Further, methods for screening compounds for such treatments are disclosed.
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6.发明公开TREATMENT OF CLIMACTERIC DISORDERS WITH NITRIC OXIDE SYNTHASE SUBSTRATES AND/OR DONORS 失效用硝酸衬底和/或DONORS更年期症状治疗
公开(公告)号：EP0730445A1
公开(公告)日：1996-09-11
申请号：EP95900760.0
申请日：1994-11-17
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/341 , A61K31/57 , A61K31/60 , Y10S514/899 , A61K31/41 , A61K31/34 , A61K31/21 , A61K2300/00 , A61K31/557 , A61K31/26
摘要： The symptoms of the climacterium are ameliorated by the administration to an afflicted individual one or both of a nitric oxide substrate and/or nitric acid donor, alone or optionally in combination with a progestin or, in the case of non-pregnant female, either a progestin or an estrogen or both.
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7.发明公开
公开(公告)号：EP0711126A1
公开(公告)日：1996-05-15
申请号：EP94905511.0
申请日：1993-12-22
CPC分类号： A61B5/411 , A61B5/04882 , A61B5/0492 , A61N1/05 , A61N1/36007
摘要： Monitoring the electrical activity of the uterus is used as a predictor of labor. In accordance with a first embodiment, the existence of gap junctions between cells is detected by stimulating the cells with electrical pulses having selective parameters and then detecting propagated signals emitted by the cells. In accordance with this embodiment, a needle (20) is provided having stimulation electrodes (44) thereon from which the stimulating pulses emanate and an array (40) of recording electrodes for detecting the pulses. In an alternative approach, an array of piezoelectric electrodes (70) is distributed within the array of recording electrodes (40). The signals detected by the recording electrodes (40) and piezoelectric electrodes (70) are monitored by a recording device (24) and stored within a computer (104).
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