公开(公告)号：EP3334404A1

公开(公告)日：2018-06-20

申请号：EP16836014.7

申请日：2016-08-12

Applicant: The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc. ,  Bayer Pharma AG

Inventor： DE WAAL, Luc ,  MEYERSON, Matthew ,  GREULICH, Heidi ,  SCHENONE, Monica ,  BURGIN, Alex ,  SACK, Ulricke ,  WU, Xiaoyun

IPC: A61K8/40 ,  A61K31/00 ,  A61K31/01 ,  A61K31/04 ,  A61K31/05 ,  A61K31/13 ,  A61K31/50 ,  A61K31/195 ,  G01N33/574

CPC classification number: A61K31/50 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/00 ,  A61K31/01 ,  A61K31/04 ,  A61K31/05 ,  A61K31/13 ,  A61K31/195 ,  A61K31/519 ,  A61K2300/00 ,  A61P35/00 ,  G01N33/57488 ,  G01N2333/916 ,  G01N2800/52

Abstract: The present invention features improved methods of identifying patients having cancer (e.g., melanoma, adenocarcinoma, lung, cervical, liver or breast cancer) using biomarkers (e.g., PDE3A, SLFN12) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., DNMDP, zardaverine, and anagrelide).

公开(公告)号：EP2961479A4

公开(公告)日：2017-07-05

申请号：EP14757027

申请日：2014-02-28

Applicant: AIRES PHARMACEUTICALS INC ,  UNIV OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： GLADWIN MARK THOMAS ,  CHAMPION HUNTER CLAY ,  PARSLEY EDWIN

IPC: A61P9/12 ,  A61K33/00 ,  A61K33/30

CPC classification number: A61K33/00 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/04

公开(公告)号：EP2437596B1

公开(公告)日：2017-05-03

申请号：EP10784088

申请日：2010-06-03

Applicant: EX-TEK LLC

Inventor： WHITBOURNE RICHARD JAMES

IPC: A01N37/36 ,  A61K8/34 ,  A61K8/368 ,  A61K8/40 ,  A61K8/81 ,  A61K8/86 ,  A61K31/60 ,  A61K31/765 ,  A61K31/78 ,  A61P17/02 ,  A61P17/04 ,  A61P41/00 ,  A61Q17/00 ,  A61Q19/08

CPC classification number: A61K31/04 ,  A61K8/347 ,  A61K8/368 ,  A61K8/418 ,  A61K8/8152 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/08 ,  A61K31/085 ,  A61K31/60 ,  A61K31/616 ,  A61K31/765 ,  A61K31/78 ,  A61K45/06 ,  A61K47/10 ,  A61K47/32 ,  A61K2800/92 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

公开(公告)号：EP2687086B1

公开(公告)日：2016-09-14

申请号：EP13188785.3

申请日：2009-07-24

Applicant: Geno LLC

Inventor： Fine, David H.

IPC: A01K67/027 ,  C07K2/00

CPC classification number: A61K31/04 ,  G01N33/6893 ,  G01N2800/324

公开(公告)号：EP2138055B2

公开(公告)日：2016-03-02

申请号：EP09161242.4

申请日：2009-05-27

Applicant: Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory

Inventor： Xu, Xinde ,  Zhou, Di ,  Zhang, Lihua ,  Shao, Bin

IPC: A61K9/48 ,  A61K45/06 ,  A21D8/04 ,  A61K31/04 ,  A61K31/07 ,  A61K33/30 ,  A23D7/005 ,  A23D9/007 ,  A21D2/14 ,  A23C9/152 ,  A21D2/02 ,  A23L5/42 ,  A23L33/00 ,  A23L21/00 ,  A23L33/16 ,  A21D2/00 ,  A23L2/00 ,  A23L33/10

CPC classification number: A61K45/06 ,  A21D2/02 ,  A21D2/14 ,  A21D8/047 ,  A23C9/1522 ,  A23D7/0053 ,  A23D9/007 ,  A23L5/44 ,  A23L21/10 ,  A23L33/105 ,  A23L33/16 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/04 ,  A61K31/07 ,  A61K33/30 ,  A61K2300/00 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/211

公开(公告)号：EP2982368A1

公开(公告)日：2016-02-10

申请号：EP14179698.7

申请日：2014-08-04

Applicant: Universität Konstanz

Inventor： Buntru, Alexander ,  Hauck, Christof ,  Mayer, Thomas ,  Paone, Christoph ,  Strittmatter, Tobias

IPC: A61K31/04 ,  A61K31/05 ,  A61K31/085 ,  A61K31/135 ,  A61K31/216 ,  A61K31/341 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4406 ,  A61K31/655 ,  A61P35/00 ,  A61P9/00

CPC classification number: A61K31/381 ,  A61K31/04 ,  A61K31/05 ,  A61K31/085 ,  A61K31/135 ,  A61K31/216 ,  A61K31/341 ,  A61K31/404 ,  A61K31/4406 ,  A61K31/655

Abstract: The present invention relates to compounds of Formula I for use in inhibiting cell migration. Further, the invention relates to a compound of Formula I for use in preventing and/or treating restenosis, for use in treating cancer and for use in preventing and/or treating cardiovascular diseases. Likewise, the invention relates to the use of a compound of Formula I for inhibiting cellular migration and/or the turnover of focal adhesions in vitro.

Abstract translation: 本发明涉及用于抑制细胞迁移的式I化合物。 此外，本发明涉及用于预防和/或治疗再狭窄的式I化合物，用于治疗癌症并用于预防和/或治疗心血管疾病。 同样，本发明涉及式I化合物在体外抑制细胞迁移和/或局部粘连的周转的用途。

公开(公告)号：EP2961479A1

公开(公告)日：2016-01-06

申请号：EP14757027.9

申请日：2014-02-28

Applicant: Aires Pharmaceuticals, Inc. ,  University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： GLADWIN, Mark, Thomas ,  CHAMPION, Hunter, Clay ,  PARSLEY, Edwin

IPC: A61P9/12

CPC classification number: A61K33/00 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/04

Abstract: Disclosed herein are methods for treating acute or chronic heart failure using inorganic nitrite, such as sodium nitrite. Sodium nitrite is a naturally occurring compound that is commonly used as a preservative in meats. Due to its vasodilative properties and involvement in the nitric oxide pathway, drug development companies and researchers are also investigating sodium nitrite as a therapeutic agent.

Abstract translation: 本文公开了使用无机亚硝酸盐如亚硝酸钠治疗急性或慢性心力衰竭的方法。 亚硝酸钠是天然存在的化合物，通常用作肉类中的防腐剂。 由于其血管扩张性质和参与一氧化氮途径，药物开发公司和研究人员也在研究亚硝酸钠作为治疗剂。

公开(公告)号：EP2838524A4

公开(公告)日：2015-12-30

申请号：EP13778577

申请日：2013-04-19

Applicant: HENNEPIN LIFE SCIENCES

Inventor： SCHLIEVERT PATRICK

IPC: A61K31/195 ,  A61K9/06 ,  A61K31/23 ,  A61K47/38 ,  A61P31/00 ,  A61P31/04

CPC classification number: A61K9/0014 ,  A61K9/06 ,  A61K31/04 ,  A61K31/195 ,  A61K31/23 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44 ,  A61K2300/00

Abstract: The present invention provides compositions and methods for topical treatment of infections. The compositions comprise glycerol monolaurate or a derivative thereof, and are administered topically, for example, to treat viral, fungal or bacterial infections.

公开(公告)号：EP2854799A1

公开(公告)日：2015-04-08

申请号：EP13798071.0

申请日：2013-05-13

Applicant: Biodiem Limited

Inventor： PHILLIPS, Julie ,  SORRELL, Tania ,  CHEN, Sharon

IPC: A61K31/36 ,  A61K31/4184 ,  A61P31/10

CPC classification number: A61K31/357 ,  A61K31/04 ,  A61K31/36 ,  A61K31/4184 ,  A61K31/423 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides a method of treatment of Scedosporium spp. infection in an animal comprising the step of administering to the infected animal an effective amount of a compound of formula I or a pharmaceutically-acceptable salt thereof

公开(公告)号：EP2453889B1

公开(公告)日：2015-04-08

申请号：EP10734105.9

申请日：2010-07-14

Applicant: Westfälische Wilhelms-Universität Münster

Inventor： HENSEL, Andreas ,  LECHTENBERG, Matthias ,  PETEREIT, Frank ,  LÖHR, Gesine ,  BEIKLER, Thomas ,  LOUIS, Andrea

IPC: A61K31/353 ,  A61K36/185 ,  A61K36/70 ,  A61K36/45 ,  A61K31/04 ,  A61K31/02 ,  A61P1/02

CPC classification number: A61K36/70 ,  A61K31/02 ,  A61K31/04 ,  A61K31/353 ,  A61K36/185 ,  A61K36/45