公开(公告)号：EP2427543A4

公开(公告)日：2017-11-29

申请号：EP10772804

申请日：2010-05-05

Applicant: ACEA BIOSCIENCES INC

Inventor： WANG XIAOBO ,  OUYANG WEI ,  LI NAN ,  XI BIAO ,  ABASSI YAMA A ,  XU XIAO

IPC: G01N33/487

CPC classification number: G01N33/48728

Abstract: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.

公开(公告)号：EP2291645A4

公开(公告)日：2013-12-25

申请号：EP09743426

申请日：2009-05-05

Applicant: ACEA BIOSCIENCES INC

Inventor： WANG XIAOBO ,  ABASSI YAMA ,  XI BIAO ,  ZHANG WEN FU ,  XU XIAO

IPC: C12M1/34 ,  G01N33/483

CPC classification number: G01N33/4836

Abstract: Systems and methods for improved monitoring of excitation-contraction coupling and excitable cells are provided, which provide millisecond time resolution. The system is capable of continuously monitoring excitation-contraction coupling in a relatively high-throughput manner. The system includes a device for monitoring cell-substrate impedance, an impedance analyzer capable of impedance measurements at millisecond time resolution, electronic circuitry that can engage the device and selectively connect two or more electrode arrays of the device to the impedance analyzer and a software program that controls the electronic circuitry and records and analyzes data obtained from the impedance analyzer.

Abstract translation: 提供了用于改进的兴奋 - 收缩偶联和可兴奋细胞的监测系统和方法，其提供毫秒的时间分辨率。 该系统能够监视连续兴奋 - 收缩偶联的在相对高通量方式进行。 该系统包括用于监测细胞 - 基底阻抗在毫秒时间分辨率到阻抗能够阻抗测量仪，电子电路也可接合设备和选择性地将所述装置的两个或多个电极阵列连接到阻抗分析仪和软件程序的装置 确实控制电子电路和记录和分析从阻抗分析仪获得的数据。

公开(公告)号：EP2188271A4

公开(公告)日：2010-12-08

申请号：EP08827232

申请日：2008-07-17

Applicant: ACEA BIOSCIENCES INC

Inventor： AN HAOYUN ,  XI BIAO ,  ABASSI YAMA ,  WANG XIAOBO ,  XU XIAO

IPC: C07D487/04 ,  A61K31/429 ,  A61K31/519 ,  A61P35/00 ,  C07D498/04 ,  C07D513/04

CPC classification number: C07D487/04 ,  C07D498/04 ,  C07D513/04