公开(公告)号：EP3589299A1

公开(公告)日：2020-01-08

申请号：EP18760427.7

申请日：2018-03-03

Applicant: ACEA Biosciences, Inc.

Inventor： ZHANG, Xiaoyu ,  ABASSI, Yama A. ,  LI, Nan ,  WANG, Xiaobo

IPC: A61K35/34 ,  C12N13/00 ,  C12N15/01 ,  G01N27/02

公开(公告)号：EP3170825B1

公开(公告)日：2019-04-10

申请号：EP16202341.0

申请日：2013-07-11

Applicant: ACEA Biosciences Inc.

Inventor： XU, Xiao ,  WANG, Xiaobo ,  MAO, Long ,  ZHAO, Li ,  XI, Biao

IPC: C07D487/04 ,  A61K31/52 ,  A61P35/00

公开(公告)号：EP2769203B1

公开(公告)日：2019-01-16

申请号：EP12841762.3

申请日：2012-10-22

Applicant: Acea Biosciences, Inc.

Inventor： LI, Nan ,  WU, Jian ,  CHEN, Ye ,  WANG, Tianxing ,  WANG, Xiaobo

IPC: G01N21/64 ,  G01N15/14

公开(公告)号：EP1742635B1

公开(公告)日：2018-03-07

申请号：EP05779301.0

申请日：2005-04-20

Applicant: Acea Biosciences, Inc.

Inventor： XU, Xiao ,  AN, Haoyun ,  WANG, Xiaobo

IPC: C07C321/20 ,  C07C323/07 ,  C07C323/16 ,  C07C323/20 ,  C07D213/52 ,  C07D333/54

CPC classification number: C07C323/07 ,  C07C321/20 ,  C07C323/16 ,  C07C323/20

Abstract: The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.

公开(公告)号：EP2536719A1

公开(公告)日：2012-12-26

申请号：EP11706123.4

申请日：2011-02-18

Applicant: Acea Biosciences, Inc.

Inventor： MAO, Long ,  WANG, Xiaobo ,  XU, Xiao ,  ZHAO, Li ,  LIU, Jia

IPC: C07D471/04 ,  C07D513/04 ,  A61K31/437 ,  A61K31/4188 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D513/04

Abstract: Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors
in vivo , and to reduce the size of tumors
in vivo . Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.

公开(公告)号：EP1527328A4

公开(公告)日：2005-12-14

申请号：EP03751801

申请日：2003-07-18

Applicant: ACEA BIOSCIENCES INC

Inventor： WANG XIAOBO ,  XU XIAO

IPC: G01N27/02 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  C12N1/00 ,  C12N13/00 ,  C12Q1/00 ,  C12Q1/02 ,  G01N20060101 ,  G01N1/00 ,  G01N27/06 ,  G01N27/12 ,  G01N27/30 ,  G01N27/327 ,  G01N27/416 ,  G01N33/50 ,  G01N33/543 ,  G01N37/00

CPC classification number: G01N33/5005 ,  G01N15/12 ,  G01N33/54366 ,  G01N33/5438

公开(公告)号：EP2769260B1

公开(公告)日：2019-09-04

申请号：EP12845835.3

申请日：2012-10-19

Applicant: Acea Biosciences, Inc.

Inventor： LI, Nan ,  CHEN, Ye ,  WANG, Xiaobo

IPC: G02B27/10

公开(公告)号：EP2427543A4

公开(公告)日：2017-11-29

申请号：EP10772804

申请日：2010-05-05

Applicant: ACEA BIOSCIENCES INC

Inventor： WANG XIAOBO ,  OUYANG WEI ,  LI NAN ,  XI BIAO ,  ABASSI YAMA A ,  XU XIAO

IPC: G01N33/487

CPC classification number: G01N33/48728

Abstract: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.

公开(公告)号：EP1815025B1

公开(公告)日：2014-04-02

申请号：EP05852157.6

申请日：2005-11-23

Applicant: Acea Biosciences, Inc.

Inventor： Abassi, Yama A. ,  Wang, Xiaobo ,  Atienza, Josephine ,  Xu, Xiao ,  Xu, Junquan

IPC: C12Q1/68 ,  C12N15/87 ,  G01N27/02 ,  G01N33/50

CPC classification number: G01N33/5008 ,  C12M35/02 ,  C12N15/87 ,  G01N15/12 ,  G01N33/48728

公开(公告)号：EP2389358A1

公开(公告)日：2011-11-30

申请号：EP09838592.5

申请日：2009-01-23

Applicant: Acea Biosciences, Inc.

Inventor： AN, Haoyun ,  MO, Xiaopeng

IPC: C07C321/16

CPC classification number: C07C319/24 ,  C07C319/28 ,  C07C323/07

Abstract: The invention provides a synthetic and manufacturing process for the preparation of the anticancer drug, fluorapacin, bis(4-fluorobenzyl)trisulfide, and related trisulfide derivatives on large scale. Also provided are processes for the purification and isolation of fluorapacin having high purity and improved stability.