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公开(公告)号：EP1527328A4
公开(公告)日：2005-12-14
申请号：EP03751801
申请日：2003-07-18
Applicant: ACEA BIOSCIENCES INC
Inventor： WANG XIAOBO , XU XIAO
IPC: G01N27/02 , C12M1/00 , C12M1/34 , C12M1/42 , C12N1/00 , C12N13/00 , C12Q1/00 , C12Q1/02 , G01N20060101 , G01N1/00 , G01N27/06 , G01N27/12 , G01N27/30 , G01N27/327 , G01N27/416 , G01N33/50 , G01N33/543 , G01N37/00
CPC classification number: G01N33/5005 , G01N15/12 , G01N33/54366 , G01N33/5438
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公开(公告)号：EP2427543A4
公开(公告)日：2017-11-29
申请号：EP10772804
申请日：2010-05-05
Applicant: ACEA BIOSCIENCES INC
Inventor： WANG XIAOBO , OUYANG WEI , LI NAN , XI BIAO , ABASSI YAMA A , XU XIAO
IPC: G01N33/487
CPC classification number: G01N33/48728
Abstract: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
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3.发明公开DEVICE AND METHOD FOR ELECTROPORATION-BASED DELIVERY OF MOECULES INTO CELLS AND DYNAMIC MONITORING OF CELL RESPONSES 有权DEVICE AND METHOD FOR分子的ON ELEKTROPORATIONSBASIS细胞和细胞应答动态监测摄食
公开(公告)号：EP1815025A4
公开(公告)日：2011-10-12
申请号：EP05852157
申请日：2005-11-23
Applicant: ACEA BIOSCIENCES INC
Inventor： ABASSI YAMA A , WANG XIAOBO , ATIENZA JOSEPHINE , XU XIAO , XU JUNQUAN
CPC classification number: G01N33/5008 , C12M35/02 , C12N15/87 , G01N15/12 , G01N33/48728
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公开(公告)号：EP1742635A4
公开(公告)日：2010-03-17
申请号：EP05779301
申请日：2005-04-20
Applicant: ACEA BIOSCIENCES INC
Inventor： XU XIAO , AN HAOYUN , WANG XIAOBO
IPC: C07C321/20 , A61K31/095 , A61K31/381 , A61K31/444 , A61K31/513 , C07C323/07 , C07C323/16 , C07C323/20 , C07D213/52 , C07D333/54
CPC classification number: C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
Abstract: The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
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5.发明公开OPTICAL ENGINE FOR FLOW CYTOMETER, FLOW CYTOMETER SYSTEM AND METHODS OF USE 审中-公开OPTISCHER MOTORFÜREIN FLUSSZYTOMETER，FLUSSZYTOMETERSYSTEM和VERFAHREN ZUR VERWENDUNG
公开(公告)号：EP3071951A4
公开(公告)日：2017-08-23
申请号：EP14863825
申请日：2014-11-19
Applicant: ACEA BIOSCIENCES INC
Inventor： LI NAN , CHEN YE , CHUNG HYUNSUN , LI ZENGQIANG , WANG XIAOBO
CPC classification number: G01N21/645 , G01N15/1434 , G01N15/1459 , G01N21/6486 , G01N33/56972 , G01N2015/1006 , G01N2015/1402 , G01N2015/1438 , G01N2015/1477 , G01N2021/6471 , G01N2021/6478 , G01N2201/06113
Abstract: An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically along a y-axis to a different vertical position along a same plane; collection optics for collecting fluorescence from the flow cell; filtration optics that filter the collected fluorescence from the flow cell into different detection channels according to wavelength ranges; and a detector for each detection channel that converts the filtered fluorescence to electrical signals, wherein electrical signals are processed so that the fluorescence from each laser at the different vertical positions is distinguished at the same detector.
Abstract translation: 一种用于台式流式细胞仪的光学引擎，该光学引擎包括一组激光器; 用于每个激光器的不同组光束成形光学器件，其中每个组包括两个透镜，以沿着x轴将水平可调地聚焦到相同的水平位置，并且沿着y轴垂直地沿着同一平面聚焦到不同的垂直位置; 用于从流动池收集荧光的收集光学器件; 过滤光学器件，其根据波长范围将从流动池收集的荧光过滤到不同的检测通道中; 以及用于每个检测通道的检测器，用于将滤波的荧光转换为电信号，其中处理电信号以使得来自不同垂直位置处的每个激光器的荧光在同一检测器处被区分。
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Patent Agency Ranking6.发明公开DEVICE FOR SPLITTING LIGHT INTO COMPONENTS HAVING DIFFERENT WAVELENGTH RANGES AND METHODS OF USE 审中-公开装置上使用不同波长的分配和使用的方法在分量的光列
公开(公告)号：EP2769260A4
公开(公告)日：2015-07-29
申请号：EP12845835
申请日：2012-10-19
Applicant: ACEA BIOSCIENCES INC
Inventor： LI NAN , CHEN YE , WANG XIAOBO
IPC: G02B27/10
CPC classification number: G02B27/1006 , G01J3/14 , G01J3/36 , G01J3/443 , G02B5/04 , G02B5/285 , G02B27/141 , G02B27/142
Abstract: A prism including a substrate faceted to provide a plurality of flat surfaces, wherein at least two of the plurality of surfaces, each including a filter coating, form at least two filter surfaces, wherein each filter surface selectively permits passage of a predetermined wavelength and reflects remaining wavelengths along an optical path towards another of the plurality of surfaces, optionally another filter surface, wherein an angle of incidence of each of the plurality of surfaces along the optical path is equal or nearly equal. An apparatus incorporating the prism and its use for splitting a light spectrum into a plurality of wavelengths or wavelength ranges.
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公开(公告)号：EP2188271A4
公开(公告)日：2010-12-08
申请号：EP08827232
申请日：2008-07-17
Applicant: ACEA BIOSCIENCES INC
Inventor： AN HAOYUN , XI BIAO , ABASSI YAMA , WANG XIAOBO , XU XIAO
IPC: C07D487/04 , A61K31/429 , A61K31/519 , A61P35/00 , C07D498/04 , C07D513/04
CPC classification number: C07D487/04 , C07D498/04 , C07D513/04
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8.发明公开LABEL-FREE MONITORING OF EXCITATION-CONTRACTION COUPLING AND EXCITABLE CELLS USING IMPEDANCE BASED SYSTEMS WITH MILLISECOND TIME RESOLUTION 有权MARK免费监测机电耦合和兴奋细胞系统研究基地阻抗MILLISECONDS时间分辨率BASIS
公开(公告)号：EP2291645A4
公开(公告)日：2013-12-25
申请号：EP09743426
申请日：2009-05-05
Applicant: ACEA BIOSCIENCES INC
Inventor： WANG XIAOBO , ABASSI YAMA , XI BIAO , ZHANG WEN FU , XU XIAO
IPC: C12M1/34 , G01N33/483
CPC classification number: G01N33/4836
Abstract: Systems and methods for improved monitoring of excitation-contraction coupling and excitable cells are provided, which provide millisecond time resolution. The system is capable of continuously monitoring excitation-contraction coupling in a relatively high-throughput manner. The system includes a device for monitoring cell-substrate impedance, an impedance analyzer capable of impedance measurements at millisecond time resolution, electronic circuitry that can engage the device and selectively connect two or more electrode arrays of the device to the impedance analyzer and a software program that controls the electronic circuitry and records and analyzes data obtained from the impedance analyzer.
Abstract translation: 提供了用于改进的兴奋 - 收缩偶联和可兴奋细胞的监测系统和方法，其提供毫秒的时间分辨率。 该系统能够监视连续兴奋 - 收缩偶联的在相对高通量方式进行。 该系统包括用于监测细胞 - 基底阻抗在毫秒时间分辨率到阻抗能够阻抗测量仪，电子电路也可接合设备和选择性地将所述装置的两个或多个电极阵列连接到阻抗分析仪和软件程序的装置 确实控制电子电路和记录和分析从阻抗分析仪获得的数据。
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9.发明公开DYNAMIC MONITORING OF ACTIVATION OF G-PROTEIN (GPCR) AND RECEPTOR TYROSINE KINASE (RTK) IN LIVING CELLS USING REAL-TIME MICROELECTRONIC CELL SENSING TECHNOLOGY 有权动态监测G蛋白（GPCR）与受体酪氨酸激酶（RTK）在活使用微电子REAL-TIME CELL探测技术活化细胞
公开(公告)号：EP1773979A4
公开(公告)日：2013-04-24
申请号：EP05786773
申请日：2005-08-04
Applicant: ACEA BIOSCIENCES INC
Inventor： ABASSI YAMA A , YU NAICHEN , ATIENZA JOSEPHINE , XU XIAO , WANG XIAOBO
CPC classification number: G01N33/4836
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10.发明公开METHOD FOR ASSAYING FOR NATURAL KILLER, CYTOTOXIC T- LYMPHOCYTE AND NEUTROPHIL-MEDIATED KILLING OF TARGET CELLS USING REAL-TIME MICROELECTRONIC CELL SENSING TECHNOLOGY 有权程序对自然杀伤细胞，细胞毒性T淋巴细胞和NEUTROPHILVERMITTELTES杀伤靶细胞中使用微电子ZELLENABTASTTECHNOLOGIE实时
公开(公告)号：EP1773980A4
公开(公告)日：2013-04-17
申请号：EP05804409
申请日：2005-08-04
Applicant: ACEA BIOSCIENCES INC
Inventor： XU XIAO , ABASSI YAMA , WANG XIAOBO
CPC classification number: G01N33/4836
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