公开(公告)号：EP2427543A4

公开(公告)日：2017-11-29

申请号：EP10772804

申请日：2010-05-05

Applicant: ACEA BIOSCIENCES INC

Inventor： WANG XIAOBO ,  OUYANG WEI ,  LI NAN ,  XI BIAO ,  ABASSI YAMA A ,  XU XIAO

IPC: G01N33/487

CPC classification number: G01N33/48728

Abstract: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.