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1.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开细胞凋亡诱导剂用于癌症治疗和免疫球蛋白及车免疫功能紊乱
公开(公告)号：EP2957558A3
公开(公告)日：2016-03-02
申请号：EP15178279.4
申请日：2011-03-10
申请人： AbbVie Inc.
发明人： DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
IPC分类号： C07C311/51 , C07D417/04 , C07D295/112 , C07D211/58 , C07D295/195
CPC分类号： C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
摘要翻译： 本发明涉及化合物，或治疗上可接受的盐，其抑制Bcl-2的抗凋亡蛋白的活性，含有该化合物的药物组合物，以及化合物和组合物的使用中，在此期间抗细胞凋亡Bcl-2蛋白是治疗疾病 表示。
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2.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开APOPTOSEINDUKTOREN ZUR BEHANDLUNG冯KREBS SOWIE VON IMMUN- UND AUTOIMMUNERKRANKUNGEN
公开(公告)号：EP2957558A2
公开(公告)日：2015-12-23
申请号：EP15178279.4
申请日：2011-03-10
申请人： AbbVie Inc.
发明人： DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
IPC分类号： C07C311/51 , C07D417/04 , C07D295/112 , C07D211/58 , C07D295/195
CPC分类号： C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗其中表达抗凋亡Bcl-2蛋白的疾病的方法。
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3.发明授权APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂用于癌症和免疫球蛋白和自身免疫性疾病的治疗
公开(公告)号：EP2550258B1
公开(公告)日：2015-08-19
申请号：EP11709579.4
申请日：2011-03-10
申请人： Abbvie Inc.
发明人： DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
IPC分类号： C07D295/112 , C07D295/195 , C07D417/04 , C07D211/58 , C07C311/51 , A61K31/451 , A61K31/495 , A61K31/18 , A61P35/00
CPC分类号： C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
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公开(公告)号：EP2642999A1
公开(公告)日：2013-10-02
申请号：EP11793928.0
申请日：2011-11-22
申请人： AbbVie Inc.
IPC分类号： A61K31/496 , A61P37/00
CPC分类号： A61K31/5377 , A61K31/496
摘要： This invention pertains to methods of treating systemic lupus erythematosus, lupus nephritis or Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl-2 anti-apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl-x L .
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公开(公告)号：EP2576546A1
公开(公告)日：2013-04-10
申请号：EP10784398.9
申请日：2010-11-22
申请人： Abbvie Inc.
发明人： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd, M.
IPC分类号： C07D471/04 , A61K31/437 , A61K35/00
CPC分类号： C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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6.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：EP2550258A2
公开(公告)日：2013-01-30
申请号：EP11709579.4
申请日：2011-03-10
申请人： Abbvie Inc.
发明人： DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
IPC分类号： C07D295/112 , C07D295/195 , C07D417/04 , C07D211/58 , C07C311/51 , A61K31/451 , A61K31/495 , A61K31/18 , A61P35/00
CPC分类号： C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白质活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白质的疾病的方法。
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