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公开(公告)号：EP2114948B1
公开(公告)日：2014-06-25
申请号：EP07855102.5
申请日：2007-12-12
申请人： AbbVie Inc.
IPC分类号： C07D487/04 , C07D243/14 , C07D241/06 , C07D241/36 , A61K31/4188 , A61K31/4965 , A61K31/502 , A61K31/5513 , A61K31/5517
CPC分类号： C07D241/08 , C07D241/44 , C07D243/08 , C07D243/14 , C07D471/04 , C07D487/04
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公开(公告)号：EP2560971B1
公开(公告)日：2014-04-09
申请号：EP11715847.7
申请日：2011-04-14
申请人： Abbvie Inc.
IPC分类号： C07D471/04 , A61K31/513 , A61K31/444 , A61P35/00
CPC分类号： C07D471/04
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公开(公告)号：EP2560971A1
公开(公告)日：2013-02-27
申请号：EP11715847.7
申请日：2011-04-14
申请人： Abbvie Inc.
IPC分类号： C07D471/04 , A61K31/513 , A61K31/444 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, Formula (I) wherein R
1a , R
1b , R
1c , X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.-
公开(公告)号：EP2069351B1
公开(公告)日：2015-10-28
申请号：EP07784490.0
申请日：2007-06-20
申请人： AbbVie Inc.
发明人： PENNING, Thomas D. , THOMAS, Sheela A. , HAJDUK, Philip J. , SAUER, Daryl R. , SARRIS, Kathy , GIRANDA, Vincent L.
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
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5.发明公开TRICYCLIC INHIBITORS OF KINASES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES 审中-公开三环激酶抑制剂的增殖性疾病的治疗
公开(公告)号：EP2731953A1
公开(公告)日：2014-05-21
申请号：EP12738337.0
申请日：2012-07-12
申请人： Abbvie Inc.
IPC分类号： C07D513/04 , C07D513/14 , A61K31/542 , A61K31/546 , A61P35/00
CPC分类号： C07D513/04 , C07D513/14
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R
1 , R
2 , R
3 , A, B, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.-
公开(公告)号：EP2665711A1
公开(公告)日：2013-11-27
申请号：EP12701822.4
申请日：2012-01-20
申请人： Abbvie Inc.
IPC分类号： C07D213/81 , C07D401/12 , C07D409/12 , C07D413/12 , A61K31/444 , A61P35/00
CPC分类号： C07D401/12 , C07D213/81 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R
1 , R
2 , R
3 , A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.-
公开(公告)号：EP2558469A1
公开(公告)日：2013-02-20
申请号：EP11716738.7
申请日：2011-04-14
申请人： Abbvie Inc.
发明人： ZHU, Guidong , GANDHI, Virajkumar B. , SHOEMAKER, Alex R. , PENNING, Thomas D. , GONG, Jianchun
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (Formula (I)) wherein R
1a , R
1b , R
1c , X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.-
公开(公告)号：EP2558459A1
公开(公告)日：2013-02-20
申请号：EP11715846.9
申请日：2011-04-14
申请人： Abbvie Inc.
发明人： ZHU, Guidong , GANDHI, Virajkumar B. , SHOEMAKER, Alex R. , PENNING, Thomas D. , GONG, Jianchun
IPC分类号： C07D401/04 , C07D471/04 , A61K31/502 , A61P35/00
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, (I) wherein R
1a , R
1b , R
1c , X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.-
公开(公告)号：EP2558469B1
公开(公告)日：2014-08-13
申请号：EP11716738.7
申请日：2011-04-14
申请人： Abbvie Inc.
发明人： ZHU, Guidong , GANDHI, Virajkumar B. , SHOEMAKER, Alex R. , PENNING, Thomas D. , GONG, Jianchun
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
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公开(公告)号：EP2696870A1
公开(公告)日：2014-02-19
申请号：EP12715262.7
申请日：2012-04-09
申请人： Abbvie Inc.
发明人： GIRANDA, Vincent Louis , SHOEMAKER, Alexander R. , BROWMAN, Kaitlin E. , JOSHI, Shailen K. , BREDERSON, Jill-Desiree , PENNING, Thomas D.
IPC分类号： A61K31/4184 , A61P25/02
CPC分类号： C07D403/04 , A61K31/337 , A61K31/4184 , A61K31/475 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the method of treating chemotherapy-induced neuropathy in a subject in need thereof with the use of a poly(ADP-ribose)polymerase (PARP) inhibitor.
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