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1.发明公开CARBOXYALKOXY-SUBSTITUIERTE ACYL-CARBOXYPHENYL-HARNSTOFFDERIVATE, VERFAHREN ZU IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权羧基烷氧基 - 取代的酰基羧基苯基脲衍生物，进程中为其及其作为药物
公开(公告)号：EP1556339A2
公开(公告)日：2005-07-27
申请号：EP03757879.6
申请日：2003-09-22
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich , VON REODERN, Erich , SCHOENAFINGER, Karl , ENHSEN, Alfons
IPC分类号： C07C275/00
CPC分类号： C07C275/54
摘要： The invention concerns carboxyalkoxy-substituted acyl-carboxyphenyl-urea derivatives of formula (I) wherein the groups are such as defined in the description and their physiologically acceptable salts and their physiologically functional derivatives. The invention also concerns a method for producing said compounds which can be used for example for treating type II diabetes.
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2.发明公开ACYL-3-CARBOXYPHENYL-HARNSTOFFDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG 有权酰基3-羧基苯基脲衍生物，用于生产及其用途
公开(公告)号：EP1497263A1
公开(公告)日：2005-01-19
申请号：EP03745772.8
申请日：2003-03-28
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , SCHOENAFINGER, Karl , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich , VON ROEDERN, Erich , ENHSEN, Alfons
IPC分类号： C07C275/54 , A61K31/192 , A61P3/10
CPC分类号： C07C275/54
摘要： The invention relates to acyl-3-carboxyphenylurea derivatives, physiologically-acceptable salts, physiologically-functional derivatives thereof and compounds of formula (I), where the groups have the given meanings, the physiologically-acceptable salts and method for production thereof. The compounds are suitable as, for example, antidiabetics.
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3.发明公开ADENOSINE ANALOGUES FOR THE TREATMENT OF THE INSULIN RESISTANCE SYNDROME AND DIABETES 审中-公开腺苷类似物为胰岛素抵抗综合征和糖尿病治疗
公开(公告)号：EP1404338A1
公开(公告)日：2004-04-07
申请号：EP02769485.0
申请日：2002-05-14
发明人： HERLING, Andreas , JÄHNE, Gerhard , MYERS, Michael, R. , MAGUIRE, Martin, P. , SPADE, Alfred, P. , EWING, William, R. , PAULS, Henry, W. , CHOI-SLEDESKI, Yong-Mi
CPC分类号： A61K31/52
摘要： The invention relates to the use of adenosine compounds described by formula (I) and certain derivatives thereof for producing a medicine for the treatment of the insulin resistance syndrome and diabetes. In formula (I), K is N, NO, or CH; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methallyl, 2-butenyl, or cycloalkyl; X is (a) or (b); E is O or S; Y is e.g. hydrogen, alkyl, aralkyl, aryl; n and p are independently 0, 1, 2 or 3 provided that n + p is at least 1; T is e.g. hydrogen, alkyl, acyl, thioacyl, halo, carboxyl; R1, R2 and R3 are independently H, alkyl, or cycloalkyl; A is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR'; B is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR'; R' and R' are e.g independently hydrogen, alkyl, aralkyl or carbamoyl.
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4.发明公开
公开(公告)号：EP1527083A1
公开(公告)日：2005-05-04
申请号：EP03740352.4
申请日：2003-06-26
发明人： BIGOT, Antony , STENGELIN, Siegfried , JÄHNE, Gerhard , HERLING, Andreas , MÜLLER, Günter , HOCK, Franz, Jakob , MYERS, Michael, R.
IPC分类号： C07H19/167 , A61K31/70
CPC分类号： C07H19/16
摘要： The present invention relates to compounds according to the general formula (I), wherein R1, A, B, Q, T, W and X have the meanings given in the description. These compounds are useful for the manufacture of a medicament for the treatment of insulin resistance, type 2 diabetes, metabolic syndrome, lipid disorders or cardiovasular disease or for providing an anti-lipolytic effect.
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5.发明公开ACYLPHENYLHARNSTOFFDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权ACYLPHENYLHARNSTOFFDERIVATE，其制造方法相同，它们作为药物
公开(公告)号：EP1294682A1
公开(公告)日：2003-03-26
申请号：EP01936399.3
申请日：2001-05-26
发明人： DEFOSSA, Elisabeth , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , BARINGHAUS, Karl-Heinz
IPC分类号： C07C275/34 , C07D295/08 , C07D307/38 , A61K31/19 , A61K31/215 , A61K31/34 , A61P3/10
CPC分类号： C07D295/088 , A61K31/17 , A61K45/06 , C07C275/54 , C07D307/38 , A61K2300/00
摘要： The invention relates to acylphenyl urea derivatives and the physiologically compatible salts and physiologically functional derivatives thereof. Such compounds correspond to the formula (I) wherein the radicals have the cited meanings. The invention also relates to a method for producing said compounds. Said compounds can be used, for example, for treating Type II diabetes.
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6.发明公开
公开(公告)号：EP1523475A1
公开(公告)日：2005-04-20
申请号：EP03763692.5
申请日：2003-07-03
发明人： SCHOENAFINGER, Karl , DEFOSSA, Elisabeth , KADEREIT, Dieter , VON ROEDERN, Erich , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich
IPC分类号： C07D211/62 , C07D249/08 , C07D257/04 , C07D271/10 , C07D253/06 , C07D231/26 , C07D307/68 , C07D235/18 , A61K31/17 , A61P3/10
CPC分类号： C07D211/60 , C07D211/62 , C07D231/12 , C07D231/26 , C07D233/56 , C07D235/18 , C07D249/08 , C07D249/12 , C07D253/07 , C07D257/04 , C07D271/10 , C07D271/113 , C07D307/68
摘要： The invention relates to heterocyclically substituted benzoylureas, in addition to their physiologically compatible salts and physiologically functional derivatives. The invention relates in particular to compounds of formula (I), in which the groups are defined as cited in the description, in addition to their physiologically compatible salts and to a method for producing said compounds. The compounds are suitable e.g. for treating type 2 diabetes.
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7.发明授权ACYLPHENYLHARNSTOFFDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权ACYLPHENYLHARNSTOFFDERIVATE，其制造方法相同，它们作为药物
公开(公告)号：EP1294682B1
公开(公告)日：2004-04-28
申请号：EP01936399.3
申请日：2001-05-26
发明人： DEFOSSA, Elisabeth , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , BARINGHAUS, Karl-Heinz
IPC分类号： C07C275/34 , C07D295/08 , C07D307/38 , A61K31/19 , A61K31/215 , A61K31/34 , A61P3/10
CPC分类号： C07D295/088 , A61K31/17 , A61K45/06 , C07C275/54 , C07D307/38 , A61K2300/00
摘要： The invention relates to acylphenyl urea derivatives and the physiologically compatible salts and physiologically functional derivatives thereof. Such compounds correspond to the formula (I) wherein the radicals have the cited meanings. The invention also relates to a method for producing said compounds. Said compounds can be used, for example, for treating Type II diabetes.
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8.发明公开
公开(公告)号：EP1404650A1
公开(公告)日：2004-04-07
申请号：EP02774016.6
申请日：2002-05-11
发明人： DEFOSSA, Elisabeth , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , VON ROEDERN, Erich , PEUKERT, Stefan , ENHSEN, Alfons , BAUER, Armin , NEISES, Berd , WENDT, Karl, Ulrich
IPC分类号： C07C275/54 , C07C323/42 , C07D211/58 , C07D213/74 , C07D213/40 , C07D295/13 , C07D285/14 , C07D319/18 , C07D207/09 , C07D209/08 , C07D401/04 , C07D209/14 , C07D317/58 , A61P3/10 , A61K31/17
CPC分类号： C07D213/40 , C07C275/54 , C07C323/42 , C07C2601/16 , C07C2602/10 , C07D209/08 , C07D211/58 , C07D285/14 , C07D295/13 , C07D295/205 , C07D317/58 , C07D319/18 , C07D401/04
摘要： The invention relates to carboxamide-substituted phenylurea derivatives and method for production thereof as medicaments, physiologically-acceptable salts and physiologically-functional derivatives thereof. Compounds of formula (I), in which the groups have the given meanings, the physiologically-acceptable salts and methods for production thereof are disclosed. Said compounds are suitable, for example, for the treatment of type II diabetes.
摘要翻译： 本发明涉及羧酰胺取代的苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理上耐受的盐及其制备方法。 该化合物适用于例如用于治疗II型糖尿病。
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9.发明公开
公开(公告)号：EP1523471A1
公开(公告)日：2005-04-20
申请号：EP03740386.2
申请日：2003-06-30
发明人： DEFOSSA, Elisabeth , KADEREIT, Dieter , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich , VON ROEDERN, Erich , SCHOENAFINGER, Karl
IPC分类号： C07C275/54 , C07D239/96 , A61K31/17 , A61P3/10
CPC分类号： C07D295/135 , C07C275/54 , C07D239/96
摘要： The invention relates to urea-substituted and urethane-substituted acylureas, to physiologically compatible salts thereof and to their physiologically functional derivatives. The invention thus relates to compounds of formula (I), wherein the radicals have the cited meanings. The invention also relates to the physiologically compatible salts of these compounds and to methods for the production thereof. The inventive compounds are suited for use, for example, as antidiabetics.
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10.发明公开N-BENZOYLUREIDO-ZIMTS UREDERIVATE, VERFAHREN ZU DEREN HERSTE LLUNG UND DEREN VERWENDUNG 有权的N- BENZOYLUREIDO肉桂酸衍生物，herste填充过程及其用途
公开(公告)号：EP1513800A1
公开(公告)日：2005-03-16
申请号：EP03732438.1
申请日：2003-05-22
发明人： SCHOENAFINGER, Karl , DEFOSSA, Elisabeth , KADEREIT, Dieter , VON ROEDERN, Erich , KLABUNDE, Thomas , BURGER, Hans-Joerg , HERLING, Andreas , WENDT, Karl-Ulrich
IPC分类号： C07C275/54 , A61P3/10 , A61K31/17 , A61K31/19
CPC分类号： C07C275/54
摘要： The invention relates to N-benzoylureidocinnamate derivatives of formula (I), where R1-R11 have the meanings given in the claims, the physiologically acceptable salts and method for production thereof. The compounds are suitable as anti-diabetics, for example.
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