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    DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES
    2.
    发明公开
    DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES 审中-公开
    使用生物标志物特征诊断脓肿或S DI症

    公开(公告)号：EP1590469A2

    公开(公告)日：2005-11-02

    申请号：EP03768887.6

    申请日：2003-11-12

    申请人： Becton, Dickinson and Company

    发明人： IVEY, Richard ,  GENTLE, Thomas ,  MOORE, Richard ,  TOWNS, Michael ,  BACHUR, Nicholas ,  ROSENSTEIN, Robert ,  GOLDENBAUM, Paul ,  SHI, Song ,  COPERTINO, Donald ,  GARRETT, James ,  TICE, Gregory

    IPC分类号： C12P19/34 ,  C12Q1/70

    CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q1/686 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/26

    摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.

    摘要翻译： 脓毒症的早期预测或诊断有利地允许在疾病快速进展到超过初始阶段之前进行临床干预，例如与高死亡率相关的严重脓毒症或脓毒性休克。 早期预测或诊断是使用分子诊断方法完成的，涉及将个体的生物标志物表达谱与从一个或多个对照或参照群（其可包括发生败血症的群体）获得的谱相比较。 识别个体生物标志物特征中表征脓毒症发作特征的特征允许临床医生诊断个体在单个时间点分离的体液中脓毒症的发作。 因此避免了在一段时间内监测患者的必要性，有利地允许在败血症的严重症状发作之前进行临床干预。

    DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES
    3.
    发明公开
    DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES 审中-公开
    使用生物标志物特征诊断脓肿或S DI症

    公开(公告)号：EP1573054A2

    公开(公告)日：2005-09-14

    申请号：EP03768885.0

    申请日：2003-11-12

    申请人： Becton, Dickinson and Company

    发明人： IVEY, Richard ,  GENTLE, Thomas ,  MOORE, Richard ,  TOWNS, Michael ,  BACHUR, Nicholas ,  ROSENSTEIN, Robert ,  NADEAU, James ,  GOLDENBAUM, Paul ,  SHI, Song ,  COPERTINO, Donald ,  GARRETT, James ,  TICE, Gregory

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： G01N33/6803 ,  C12Q1/6837 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/26

    摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.

    摘要翻译： 脓毒症的早期预测或诊断有利地允许在疾病快速进展到超过初始阶段之前进行临床干预，例如与高死亡率相关的严重脓毒症或脓毒性休克。 早期预测或诊断是通过比较个体的生物标志物表达谱与从一个或多个对照或参照群（其可能包括发生败血症的群体）获得的概况来完成的。 识别个体生物标志物特征中表征脓毒症发作特征的特征允许临床医生诊断在单个时间点从个体分离的体液中发生脓毒症的发作。 因此避免了在一段时间内监测患者的必要性，有利地允许在败血症的严重症状发作之前进行临床干预。

    DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES
    5.
    发明公开
    DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES 审中-公开
    使用生物标志物特征诊断脓肿或S DI症

    公开(公告)号：EP1565570A2

    公开(公告)日：2005-08-24

    申请号：EP03768886.8

    申请日：2003-11-12

    申请人： Becton, Dickinson and Company

    发明人： IVEY, Richard ,  GENTLE, Thomas ,  MOORE, Richard ,  TOWNS, Michael ,  SIUZDAK, Gary ,  WANT, Elizabeth ,  SHEN, Zhouxin ,  BACHUR, Nicholas ,  ROSENSTEIN, Robert ,  NADEAU, James ,  GOLDENBAUM, Paul ,  SHI, Song ,  COPERTINO, Donald ,  GARRETT, James ,  TICE, Gregory

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/6848 ,  C12Q1/6883 ,  G01N33/6803 ,  G01N2800/26 ,  Y10T436/24

    摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis or SIRS from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.

    摘要翻译： 脓毒症的早期预测或诊断有利地允许在疾病快速进展到超过初始阶段之前进行临床干预，例如与高死亡率相关的严重脓毒症或脓毒性休克。 早期预测或诊断是通过比较个体的生物标志物表达谱与从一个或多个对照或参照群（其可能包括发生败血症的群体）获得的概况来完成的。 识别个体生物标志物特征中表征脓毒症发作特征的特征允许临床医生诊断在单个时间点从个体分离的体液中发生脓毒症或SIRS。 因此避免了在一段时间内监测患者的必要性，有利地允许在败血症的严重症状发作之前进行临床干预。