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公开(公告)号：EP2892648B1
公开(公告)日：2018-05-30
申请号：EP13763159.4
申请日：2013-09-04
发明人： SHI, Song , YANG, Mei , BERNDT, Klaus, W. , LOSADA, Robert, J. , CRAWFORD, Jamieson, W. , ATTRI, Ravi , BATTLES, Christopher, A. , BARTFELD, Benjamin, R. , HIRES, Gregory, R.
IPC分类号： B01L3/00
CPC分类号： B01L3/50 , B01L3/502 , B01L3/50215 , B01L3/5082 , B01L3/50825 , B01L2300/06 , B01L2300/0636 , B01L2300/0663 , G01N1/40
摘要： A method for detecting the presence of a microorganism in a fluid sample is disclosed. The method includes providing a fluid specimen within a specimen collection container having a sidewall defining an interior therein. The interior includes a mechanical separator adapted for separating the fluid sample into first and second phases within the specimen collection container and a sensing element capable of detecting the presence of a microorganism disposed therein. The method includes subjecting the specimen collection container to applied rotational force to isolate a concentrated microorganism region. The method also includes detecting by a sensing element the presence or absence of a microorganism within the concentrated microorganism region.
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公开(公告)号：EP1575978A2
公开(公告)日：2005-09-21
申请号：EP03768891.8
申请日：2003-11-12
发明人： IVEY, Richard , GENTLE, Thomas , MOORE, Richard , TOWNS, Michael , BACHUR, Nicholas , ROSENSTEIN, Robert , GOLDENBAUM, Paul , SHI, Song , COPERTINO, Donald , GARRETT, James , TICE, Gregory
IPC分类号： C07H21/04
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q1/686 , C12Q2600/158 , G01N33/6893 , G01N2800/26
摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.
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公开(公告)号：EP2892648A1
公开(公告)日：2015-07-15
申请号：EP13763159.4
申请日：2013-09-04
发明人： SHI, Song , YANG, Mei , BERNDT, Klaus, W. , LOSADA, Robert, J. , CRAWFORD, Jamieson, W. , ATTRI, Ravi , BATTLES, Christopher, A. , BARTFELD, Benjamin, R. , HIRES, Gregory, R.
IPC分类号： B01L3/00
CPC分类号： B01L3/50215 , B01L2300/0636 , B01L2300/0663
摘要： A method for detecting the presence of a microorganism in a fluid sample is disclosed. The method includes providing a fluid specimen within a specimen collection container having a sidewall defining an interior therein. The interior includes a mechanical separator adapted for separating the fluid sample into first and second phases within the specimen collection container and a sensing element capable of detecting the presence of a microorganism disposed therein. The method includes subjecting the specimen collection container to applied rotational force to isolate a concentrated microorganism region. The method also includes detecting by a sensing element the presence or absence of a microorganism within the concentrated microorganism region.
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公开(公告)号：EP2834367A1
公开(公告)日：2015-02-11
申请号：EP13773119.6
申请日：2013-04-04
发明人： LI, Xiao , ZHANG, Yongqiang , KOPHER, Kenneth, Anthony , MANTLO, John, D. , POPE, William, Alfred , SHI, Song , YUP, Axel, A.
CPC分类号： C12Q1/06 , C12Q1/6806 , C12Q2527/125 , C12Q2563/173 , C12Q2565/626
摘要： Described herein are methods and reagents for identifying and analyzing at least one microorganism (e.g. bacteria) in a sample and reducing the background signal intensity obtained when analyzing the sample by flow cytometry. The sample is prepared by combining the sample with a background signal-reducing molecule or with a nucleic acid stain covalently linked to a quencher. A portion of the particulate matter in the sample can optionally be removed with a resin prior to staining with a nucleic acid stain.
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5.发明公开
公开(公告)号：EP2795306A1
公开(公告)日：2014-10-29
申请号：EP12860579.7
申请日：2012-12-19
IPC分类号： G01N27/414 , G01N33/49
CPC分类号： G01N27/4145 , B01L3/5021 , B01L2300/0636 , B01L2300/0851 , B01L2300/0893 , B01L2400/0409 , B01L2400/0415 , B01L2400/043 , C12Q1/04 , G01N33/48735 , G01N2800/26
摘要： An array of micro-chambers (220) with individual ion sensitive field effect transistors (ISFETs) (300) disposed therein for monitoring single cell activity in the microarray to determine the presence or absence of microorganisms in a sample (390). In addition to the presence or absence of a single cell, certain further embodiments contemplate monitoring cell behavior. Cell behavior includes the entire range of cell activity as well as cell response to changes in environmental conditions of changes in response due to the addition of sample constituents.
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公开(公告)号：EP1590469A2
公开(公告)日：2005-11-02
申请号：EP03768887.6
申请日：2003-11-12
发明人： IVEY, Richard , GENTLE, Thomas , MOORE, Richard , TOWNS, Michael , BACHUR, Nicholas , ROSENSTEIN, Robert , GOLDENBAUM, Paul , SHI, Song , COPERTINO, Donald , GARRETT, James , TICE, Gregory
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q1/686 , C12Q2600/158 , G01N33/6893 , G01N2800/26
摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.
摘要翻译： 脓毒症的早期预测或诊断有利地允许在疾病快速进展到超过初始阶段之前进行临床干预，例如与高死亡率相关的严重脓毒症或脓毒性休克。 早期预测或诊断是使用分子诊断方法完成的，涉及将个体的生物标志物表达谱与从一个或多个对照或参照群（其可包括发生败血症的群体）获得的谱相比较。 识别个体生物标志物特征中表征脓毒症发作特征的特征允许临床医生诊断个体在单个时间点分离的体液中脓毒症的发作。 因此避免了在一段时间内监测患者的必要性，有利地允许在败血症的严重症状发作之前进行临床干预。
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公开(公告)号：EP1573054A2
公开(公告)日：2005-09-14
申请号：EP03768885.0
申请日：2003-11-12
发明人： IVEY, Richard , GENTLE, Thomas , MOORE, Richard , TOWNS, Michael , BACHUR, Nicholas , ROSENSTEIN, Robert , NADEAU, James , GOLDENBAUM, Paul , SHI, Song , COPERTINO, Donald , GARRETT, James , TICE, Gregory
CPC分类号： G01N33/6803 , C12Q1/6837 , C12Q1/686 , C12Q1/6883 , C12Q2600/158 , G01N2800/26
摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.
摘要翻译： 脓毒症的早期预测或诊断有利地允许在疾病快速进展到超过初始阶段之前进行临床干预，例如与高死亡率相关的严重脓毒症或脓毒性休克。 早期预测或诊断是通过比较个体的生物标志物表达谱与从一个或多个对照或参照群（其可能包括发生败血症的群体）获得的概况来完成的。 识别个体生物标志物特征中表征脓毒症发作特征的特征允许临床医生诊断在单个时间点从个体分离的体液中发生脓毒症的发作。 因此避免了在一段时间内监测患者的必要性，有利地允许在败血症的严重症状发作之前进行临床干预。
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公开(公告)号：EP1963527A2
公开(公告)日：2008-09-03
申请号：EP06845433.9
申请日：2006-12-14
发明人： MOORE, Richard, L. , SHI, Song , NUSSBAUMER, William, A. , WHITEFORD, Craig, C. , GENTLE, Thomas, M. , GARRETT, James, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： Methods and apparatus for predicting the development of sepsis in a subject at risk for developing sepsis are provided. Features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods and apparatus for predicting the development of a stage of sepsis in a subject at risk for developing a stage of sepsis are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to have the stage of sepsis if these feature values satisfy a particular value set. Methods and apparatus for diagnosing sepsis in a subject are provided. A plurality of features in a biomarker profile of the subject is evaluated. The subject is likely to develop sepsis when the plurality of features satisfies a particular value set.
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公开(公告)号：EP1664721A2
公开(公告)日：2006-06-07
申请号：EP04784764.5
申请日：2004-09-22
发明人： GENTLE, Thomas , MOORE, Richard , WINEGAR, Thomas , SHI, Song , JIN, Zhe
IPC分类号： G01N1/00
CPC分类号： H01J49/0009 , Y10T436/143333
摘要： The present invention pertains to methods and compositions for quantifying the levels of at least one biomolecular analyte in a sample or extract by mass spectrometry using at least one dendrimer internal standard, as shown in Figure 1. Examples of suitable dendrimer standards are poly(ethylene glycol) (PEG dendrimer and poly(amidoamine) (PAMAM) dendrimer. In one embodiment a labile internal standard sensitive to heat or protease is used together with the dendrimer standard.
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公开(公告)号：EP1565570A2
公开(公告)日：2005-08-24
申请号：EP03768886.8
申请日：2003-11-12
发明人： IVEY, Richard , GENTLE, Thomas , MOORE, Richard , TOWNS, Michael , SIUZDAK, Gary , WANT, Elizabeth , SHEN, Zhouxin , BACHUR, Nicholas , ROSENSTEIN, Robert , NADEAU, James , GOLDENBAUM, Paul , SHI, Song , COPERTINO, Donald , GARRETT, James , TICE, Gregory
IPC分类号： C12Q1/68
CPC分类号： G01N33/6848 , C12Q1/6883 , G01N33/6803 , G01N2800/26 , Y10T436/24
摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis or SIRS from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.
摘要翻译： 脓毒症的早期预测或诊断有利地允许在疾病快速进展到超过初始阶段之前进行临床干预，例如与高死亡率相关的严重脓毒症或脓毒性休克。 早期预测或诊断是通过比较个体的生物标志物表达谱与从一个或多个对照或参照群（其可能包括发生败血症的群体）获得的概况来完成的。 识别个体生物标志物特征中表征脓毒症发作特征的特征允许临床医生诊断在单个时间点从个体分离的体液中发生脓毒症或SIRS。 因此避免了在一段时间内监测患者的必要性，有利地允许在败血症的严重症状发作之前进行临床干预。
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