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1.发明公开2-(IH-THIENO [3,2-C] PYRAZOL-3YL)-IH-INDOLE DERIVATIVES AND RELATED COMPOUNDS AS TEC KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS AND IMMUNOLOGICAL DISORDERS 审中-公开2-（IH-噻吩并[3,2-c]吡唑-3-基）-1H-吲哚衍生物和相关化合物TEC激酶抑制剂用于治疗炎症和免疫疾病的治疗
公开(公告)号：EP1968580A2
公开(公告)日：2008-09-17
申请号：EP06840120.7
申请日：2006-12-06
IPC分类号： A61K31/4162 , C07D495/04 , A61P29/00 , A61P37/00 , A61P11/00
CPC分类号： C07D495/04
摘要： Disclosed are compounds of formula (I): (F) wherein Ri, R2, X and Ar are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
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公开(公告)号：EP2321274A1
公开(公告)日：2011-05-18
申请号：EP09789924.9
申请日：2009-06-24
发明人： BENTZIEN, Joerg, Martin , BOYER, Stephen, James , BURKE, Jennifer , ELDRUP, Anne, Bettina , GUO, Xin , HUBER, John, David , KIRRANE, Thomas, Martin , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David
IPC分类号： C07D207/09 , C07D211/34 , C07D211/82 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06
CPC分类号： C07D211/34 , C07D207/09 , C07D211/82 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D471/04
摘要： Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.
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3.发明公开PYRROLO (2,3-B) PYRIDINE DERIVATIVES USEFUL AS TEC KINASE INHIBITORS 审中-公开PYROLLO吡啶衍生物NUTZLICH ALS TEC-KINASE-INHIBITOREN
公开(公告)号：EP1957491A2
公开(公告)日：2008-08-20
申请号：EP06837092.3
申请日：2006-11-07
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P37/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of formula (I), wherein Q, R1, R2, R3, R4 and R5 are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.
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