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公开(公告)号：EP2321274A1
公开(公告)日：2011-05-18
申请号：EP09789924.9
申请日：2009-06-24
发明人： BENTZIEN, Joerg, Martin , BOYER, Stephen, James , BURKE, Jennifer , ELDRUP, Anne, Bettina , GUO, Xin , HUBER, John, David , KIRRANE, Thomas, Martin , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David
IPC分类号： C07D207/09 , C07D211/34 , C07D211/82 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06
CPC分类号： C07D211/34 , C07D207/09 , C07D211/82 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D471/04
摘要： Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.
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公开(公告)号：EP2509980A1
公开(公告)日：2012-10-17
申请号：EP10787970.2
申请日：2010-11-30
发明人： BOYER, Stephen, James , GAO, Donghong, Amy , GUO, Xin , KIRRANE, Thomas, Martin, Jr. , SARKO, Christopher, Ronald , SNOW, Roger,John , SOLEYMANZADEH, Fariba , ZHANG, Yunlong
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/551 , A61P9/00 , A61P29/00
CPC分类号： C07D487/04 , C07D487/20 , C07D491/20
摘要： Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.
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3.发明公开HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE 有权杂环相关的PYRROLOPYRIDIN-或苯并咪唑
公开(公告)号：EP2509979A1
公开(公告)日：2012-10-17
申请号：EP10788192.2
申请日：2010-12-01
发明人： BOYER, Stephen, James , BURKE, Jennifer , GUO, Xin , KIRRANE JR., Thomas, Martin , SNOW, Roger, John , ZHANG, Yunlong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14
摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R
1 , R
2 , R
3 , R
4 , R
5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.-
4.发明授权HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE 有权杂环相关的PYRROLOPYRIDIN-或苯并咪唑
公开(公告)号：EP2509979B1
公开(公告)日：2016-05-25
申请号：EP10788192.2
申请日：2010-12-01
发明人： BOYER, Stephen, James , BURKE, Jennifer , GUO, Xin , KIRRANE JR., Thomas, Martin , SNOW, Roger, John , ZHANG, Yunlong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14
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