公开(公告)号：EP3954993A1

公开(公告)日：2022-02-16

申请号：EP21186197.6

申请日：2016-02-04

申请人： Bristol-Myers Squibb Company ,  Roche Innovation Center Copenhagen A/S

发明人： OLSON, Richard E. ,  CACACE, Angela, M. ,  HAGEDORN, Peter ,  HØG, Anja Mølhart ,  NIELSEN, Niels, Fisker ,  LI, Dong ,  BROWN, Jeffrey, M. ,  MERCER, Stephen, E. ,  JENSEN, Marianne, Lerbech

IPC分类号： G01N33/50

摘要： The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.

公开(公告)号：EP3254104A1

公开(公告)日：2017-12-13

申请号：EP16709167.7

申请日：2016-02-04

申请人： Bristol-Myers Squibb Company ,  Roche Innovation Center Copenhagen A/S

发明人： OLSON, Richard E. ,  CACACE, Angela, M. ,  HAGEDORN, Peter ,  HØG, Anja Mølhart ,  NIELSEN, Niels, Fisker ,  LI, Dong ,  BROWN, Jeffrey, M. ,  MERCER, Stephen, E. ,  JENSEN, Marianne, Lerbech

IPC分类号： G01N33/50

CPC分类号： G01N33/5058 ,  G01N33/5014

摘要： The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.