专利检索 ap:("Bristol-Myers Squibb Company" OR "Roche Innovation Center Copenhagen A/S") AND inv:"OLSON, Richard E." 第 1 页

1.

发明公开
LNA OLIGONUCLEOTIDES WITH ALTERNATING FLANKS 审中-公开
标题翻译：具有交替方向的LNA寡核苷酸

公开(公告)号：EP3253871A1

公开(公告)日：2017-12-13

申请号：EP16708801.2

申请日：2016-02-04

申请人： Bristol-Myers Squibb Company , Roche Innovation Center Copenhagen A/S

发明人： HAGEDORN, Peter , OLSON, Richard E. , HØG, Anja Mølhart , JENSEN, Marianne Lerbech , LI, Dong , NIELSEN, Niels Fisker

IPC分类号： C12N15/11 , C12N15/113 , A61K31/712

CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/343 , C12N2310/346 , C12N2310/351

摘要： The present invention relates to LNA oligomers having two flanks, wherein one or both flanks comprise alternating LNA and DNA nucleosides.

2.

发明公开
ANGPTL2 ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF 审中-公开

公开(公告)号：EP3947680A2

公开(公告)日：2022-02-09

申请号：EP20722089.8

申请日：2020-04-02

申请人： Bristol-Myers Squibb Company , Roche Innovation Center Copenhagen A/S

发明人： ANDERSON, Brian R. , OLSON, Richard E. , MCDONALD, Ivar M. , MERCER, Stephen E. , HAGEDORN, Peter , JENSEN, Marianne Lerbech

IPC分类号： C12N15/113 , C07K14/515

3.

发明公开
METHODS OF SELECTING THERAPEUTIC MOLECULES 审中-公开

公开(公告)号：EP3954993A1

公开(公告)日：2022-02-16

申请号：EP21186197.6

申请日：2016-02-04

申请人： Bristol-Myers Squibb Company , Roche Innovation Center Copenhagen A/S

发明人： OLSON, Richard E. , CACACE, Angela, M. , HAGEDORN, Peter , HØG, Anja Mølhart , NIELSEN, Niels, Fisker , LI, Dong , BROWN, Jeffrey, M. , MERCER, Stephen, E. , JENSEN, Marianne, Lerbech

IPC分类号： G01N33/50

摘要： The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.

4.

发明公开
METHODS OF SELECTING THERAPEUTIC MOLECULES 审中-公开
标题翻译：选择治疗分子的方法

公开(公告)号：EP3254104A1

公开(公告)日：2017-12-13

申请号：EP16709167.7

申请日：2016-02-04

申请人： Bristol-Myers Squibb Company , Roche Innovation Center Copenhagen A/S

发明人： OLSON, Richard E. , CACACE, Angela, M. , HAGEDORN, Peter , HØG, Anja Mølhart , NIELSEN, Niels, Fisker , LI, Dong , BROWN, Jeffrey, M. , MERCER, Stephen, E. , JENSEN, Marianne, Lerbech

IPC分类号： G01N33/50

CPC分类号： G01N33/5058 , G01N33/5014

摘要： The present disclosure provides methods of using a calcium oscillation assay and/or a sequence score calculation to identify a molecule that is safe for administration. The disclosure also includes a method of selecting or identifying a molecule having tolerable in vivo neurotoxicity using a calcium oscillation assay, a sequence score method, an in vivo tolerability assay, or any combination thereof.

5.

发明公开
ALPHA-SYNUCLEIN ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF 审中-公开

公开(公告)号：EP3737759A1

公开(公告)日：2020-11-18

申请号：EP19700779.2

申请日：2019-01-11

申请人： Roche Innovation Center Copenhagen A/S

发明人： HAGEDORN, Peter , OLSON, Richard E. , CACACE, Angela M. , JENSEN, Marianne Lerbech , BROWN, Jeffrey M. , MEREDITH,JR., Jere E. , PENDRI, Annapurna , MACDONALD, Ivar M. , GILL, Martin

IPC分类号： C12N15/113 , C07K14/47 , A61K48/00

6.

发明公开
SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T CELL ACTIVATORS 审中-公开

公开(公告)号：EP4081524A1

公开(公告)日：2022-11-02

申请号：EP20845305.0

申请日：2020-12-22

申请人： Bristol-Myers Squibb Company

发明人： VELAPARTHI, Upender , DARNE, Chetan Padmakar , OLSON, Richard E. , JALAGAM, Prasada Rao , WARRIER, Jayakumar Sankara

IPC分类号： C07D471/04 , A61K31/519 , A61K31/496 , A61P35/00

7.

发明公开
SUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS T CELL ACTIVATORS 审中-公开

公开(公告)号：EP4081522A1

公开(公告)日：2022-11-02

申请号：EP20842856.5

申请日：2020-12-22

申请人： Bristol-Myers Squibb Company

发明人： VELAPARTHI, Upender , DARNE, Chetan Padmakar , OLSON, Richard E. , WARRIER, Jayakumar Sankara

IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61K31/4375 , A61P35/00

8.

发明公开
SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL ACTIVATORS 审中-公开

公开(公告)号：EP4021901A1

公开(公告)日：2022-07-06

申请号：EP20768221.2

申请日：2020-08-27

申请人： Bristol-Myers Squibb Company

发明人： VELAPARTHI, Upender , OLSON, Richard E. , DARNE, Chetan Padmakar , DASGUPTA, Bireshwar , WARRIER, Jayakumar Sankara , RAHAMAN, Hasibur , JALAGAM, Prasada Rao , ROY, Saumya , GRUNENFELDER, Denise C.

IPC分类号： C07D401/04 , A61P31/12 , A61P35/00 , A61K31/519

9.

发明公开
AZA-BICYCLIC AMINE N-OXIDE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGAND PRO-DRUGS 有权
标题翻译： AZA-BICYCLISCHE AMIN-N-OXIDVERBINDUNGEN ALS ALPHA-7-NIKOTINISCHE ACETYLCHOLINREZEPTORLIGAND-PRODRUGS

公开(公告)号：EP2563796A1

公开(公告)日：2013-03-06

申请号：EP11722648.0

申请日：2011-04-29

申请人： Bristol-Myers Squibb Company

发明人： LENTZ, Kimberley A. , DENTON, Rex , COOK, James H., II , MCDONALD, Ivar M. , KING, Dalton , OLSON, Richard E. , WANG, Nenghui , MATE, Robert A. , IWUAGWU, Christiana I. , ZUSI, F. Christopher , MACOR, John E. , HILL, Matthew D. , FANG, Haiquan

IPC分类号： C07D498/10 , A61K31/435 , A61K31/47 , A61K31/497 , A61K31/506 , A61P25/00

CPC分类号： C07D498/10

摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are prodrugs for ligands, agonists, and partial agonists for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

10.

发明公开
NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS 审中-公开

公开(公告)号：EP3774824A1

公开(公告)日：2021-02-17

申请号：EP19720286.4

申请日：2019-04-12

申请人： Bristol-Myers Squibb Company , The Scripps Research Institute

发明人： SCHMIDT, Michael Anthony , ZHENG, Bin , KNOUSE, Kyle , DEGRUYTER, Justine , EASTGATE, Martin D. , BARAN, Phil , EWING, William R. , OLSON, Richard E. , MCDONALD, Ivar M.

IPC分类号： C07F9/6574 , C07H19/00 , C07H19/11 , C07H21/04