公开(公告)号：EP1224182A1

公开(公告)日：2002-07-24

申请号：EP00969659.2

申请日：2000-10-20

申请人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) ,  Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) ,  UNIVERSITE DE BERNE

发明人： DODD, Robert ,  RAZET, Rodolphe ,  POTIER, Pierre, Jean-Paul ,  SIEGHART, Werner ,  JURSKY, Frantisek ,  FURTMULLER, Roman ,  SIGEL, Erwin ,  THOMET, Urs

IPC分类号： C07D405/04 ,  C07D409/04 ,  C07D401/04 ,  A61K31/4725 ,  A61P25/00

CPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04

摘要： The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; groups R', identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R'' represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating η-amino-butyric acid activity and as medicine for treating nervous disorders.

公开(公告)号：EP1226133A2

公开(公告)日：2002-07-31

申请号：EP00969660.0

申请日：2000-10-20

申请人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) ,  Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) ,  Université de Bern

发明人： DODD, Robert ,  EL HADRI, Ahmed ,  POTIER, Pierre, Jean-Paul ,  SIEGHART, Werner ,  JURSKY, Frantisek ,  FURTMULLER, Roman ,  SIGEL, Erwin ,  THOMET, Urs

IPC分类号： C07D307/33 ,  A61K31/365 ,  A61P25/00 ,  A61P25/08 ,  A61P25/22

CPC分类号： C07D307/33 ,  A61K31/365

摘要： The invention concerns compounds represented by general formula (I) wherein: Z represents a sulphur or oxygen atom; the groups R1 and R2, identical or different, represent each an alkyl group or an alkenyl group; X represents a CO, a CO2, an SO or and SO2 and the group R represents an alkyl, aryl, alkenyl or aralkyl group, provided that when Z represents an oxygen atom, X an SO2 and R a group (a), R1 and R2 do not both represent the methyl group. The invention also concerns methods for preparing said compounds, pharmaceutical compositions containing them and their use as promoter of η-aminobutyric acid and as medicine particularly designed for treating nervous disorders.

公开(公告)号：EP1224182B1

公开(公告)日：2003-07-16

申请号：EP00969659.2

申请日：2000-10-20

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) ,  UNIVERSITE DE BERNE

发明人： DODD, Robert ,  RAZET, Rodolphe ,  POTIER, Pierre, Jean-Paul ,  SIEGHART, Werner ,  JURSKY, Frantisek ,  FURTMULLER, Roman ,  SIGEL, Erwin ,  THOMET, Urs

IPC分类号： C07D405/04 ,  C07D409/04 ,  C07D401/04 ,  A61K31/4725 ,  A61P25/00

CPC分类号： C07D401/04 ,  C07D405/04 ,  C07D409/04

摘要： The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; groups R', identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R'' represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating η-amino-butyric acid activity and as medicine for treating nervous disorders.

公开(公告)号：EP1226133B1

公开(公告)日：2004-04-07

申请号：EP00969660.0

申请日：2000-10-20

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) ,  Université de Bern

发明人： DODD, Robert ,  EL HADRI, Ahmed ,  POTIER, Pierre, Jean-Paul ,  SIEGHART, Werner ,  JURSKY, Frantisek ,  FURTMULLER, Roman ,  SIGEL, Erwin ,  THOMET, Urs

IPC分类号： C07D307/33 ,  A61K31/365 ,  A61P25/00 ,  A61P25/08 ,  A61P25/22

CPC分类号： C07D307/33 ,  A61K31/365

摘要： The invention concerns compounds represented by general formula (I) wherein: Z represents a sulphur or oxygen atom; the groups R1 and R2, identical or different, represent each an alkyl group or an alkenyl group; X represents a CO, a CO2, an SO or and SO2 and the group R represents an alkyl, aryl, alkenyl or aralkyl group, provided that when Z represents an oxygen atom, X an SO2 and R a group (a), R1 and R2 do not both represent the methyl group. The invention also concerns methods for preparing said compounds, pharmaceutical compositions containing them and their use as promoter of η-aminobutyric acid and as medicine particularly designed for treating nervous disorders.

公开(公告)号：EP1284963A1

公开(公告)日：2003-02-26

申请号：EP01938319.9

申请日：2001-05-23

申请人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： RUAT, Martial ,  DODD, Robert ,  FAURE, Hélène, Véronique ,  DAUBAN, Philippe, Marcel ,  KESSLER, Albane ,  POTIER, Pierre, Jean-Paul

IPC分类号： C07D209/14 ,  A61K31/4045 ,  A61P5/18 ,  C07D209/42

CPC分类号： C07D209/42 ,  C07D209/14

摘要： The invention concerns compounds of general formula (I) wherein: the group X represents a -NR4, -CH = N or -CHR5-NR4- group; the group Y represents an oxygen or sulphur atom or a NR, -CR5, -CHR5-, -CR5=CR6- or -CHR5-CHR6 group provided that when group X represents the -CH=N- or -CHR5-NR4- group, group Y represents an oxygen or a sulphur atom or a Nr, -CR5 or -CHR group; the group R represents a hydrogen atom or an alkyl, aryl or aralkyl group; the groups R1, R5 and R6, identical or different, represent each a hydrogen or halogen atom or an alkyl or alkoxy group; the group R2 represents a hydrogen atom or an alkyl group; the group R3 represents an aryl group; and the group R4 represents a hydrogen atom, an alkyl, aryl, aralkyl, alkylsulphonamide, arylsulphonamide or aralkylsulphonamide group; and their salt with a pharmaceutically acceptable acid, in the form of a racemic mixture and their optically pure isomer. The invention also concerns their preparation, pharmaceutical compositions containing them and their use as CaSR activity modulator and as medicine for preferably treating diseases or physiological disorders involving the intervention of CaSR activity modulation.

公开(公告)号：EP1235797A1

公开(公告)日：2002-09-04

申请号：EP00976121.4

申请日：2000-11-08

申请人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： RUAT, Martial ,  POTIER, Pierre, Jean-Paul, Serge, Jacques ,  DODD, Robert ,  DAUBAN, Philippe, Marcel ,  FAURE, Hélène, Véronique

IPC分类号： C07C311/18 ,  C07C311/29 ,  C07C211/30 ,  A61K31/135 ,  A61K31/18

CPC分类号： C07C311/18 ,  C07C211/27 ,  C07C311/29 ,  C07D333/34

摘要： The invention concerns compounds of general formula (I) wherein: X represents a SO2 or CH2 group; R1 represents a hydrogen or halogen atom or an alkoxy, aryl aralkyl group or an alkyl group substituted or not with one or several halogen atoms, n is equal to 0, 1 or 2, and R2 represents a hydrogen or halogen atom or an alkyl or alkoxy group, and their salt with a pharmaceutically acceptable acid. The invention also concerns the method for preparing said compounds, pharmaceutical compositions containing them and their use as modulator of CaSR activity and as medicine particularly designed for treating diseases or physiological disorders involving modulation of CaSR activity.

摘要翻译： 本发明涉及通式（I）的化合物，其中：X表示SO 2或CH 2基团; R1代表氢或卤素原子或烷氧基，芳基芳烷基或被一个或多个卤素原子取代或未被取代的烷基，n等于0,1或2，R2代表氢或卤素原子或烷基或 烷氧基，及其与药学上可接受的酸形成的盐。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其作为CaSR活性调节剂的用途，以及特别设计用于治疗涉及调节CaSR活性的疾病或生理学障碍的药物。