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1.发明公开3-AMINO-2,2-DI-C-ALKYL-1,4-BUTYROLACTONES ET 1,4-THIOBUTYROLACTONES N-SUBSTITUEES UTILES COMME STIMULANT DE L'ACTIVITE DE L'ACIDE $g(g)-AMINOBUTYRIQUE ET DANS LE TRAITEMENT DES TROUBLES NERVEUX ET LEUR PROCEDE DE PREPARATION 有权3-氨基-2,2--DI-C-烷基-1,4-丁内酯和N-取代的1,4-硫代丁内酯伽玛AMINOBUTANSÄUREAKTIVITÄT步伐和神经障碍的治疗中使用FIND，AND METHOD FOR PRODUCING
公开(公告)号：EP1226133A2
公开(公告)日：2002-07-31
申请号：EP00969660.0
申请日：2000-10-20
申请人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) , Université de Bern
发明人： DODD, Robert , EL HADRI, Ahmed , POTIER, Pierre, Jean-Paul , SIEGHART, Werner , JURSKY, Frantisek , FURTMULLER, Roman , SIGEL, Erwin , THOMET, Urs
IPC分类号： C07D307/33 , A61K31/365 , A61P25/00 , A61P25/08 , A61P25/22
CPC分类号： C07D307/33 , A61K31/365
摘要： The invention concerns compounds represented by general formula (I) wherein: Z represents a sulphur or oxygen atom; the groups R1 and R2, identical or different, represent each an alkyl group or an alkenyl group; X represents a CO, a CO2, an SO or and SO2 and the group R represents an alkyl, aryl, alkenyl or aralkyl group, provided that when Z represents an oxygen atom, X an SO2 and R a group (a), R1 and R2 do not both represent the methyl group. The invention also concerns methods for preparing said compounds, pharmaceutical compositions containing them and their use as promoter of η-aminobutyric acid and as medicine particularly designed for treating nervous disorders.
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2.发明公开1-(LACTONE)-ISOQUINOLONES N-SUBSTITUEES POUR LE TRAITEMENT DES TROUBLES NERVEUX 有权N-取代的1-（内酯）-ISOCHINOLONE神经障碍的治疗
公开(公告)号：EP1224182A1
公开(公告)日：2002-07-24
申请号：EP00969659.2
申请日：2000-10-20
申请人： CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) , UNIVERSITE DE BERNE
发明人： DODD, Robert , RAZET, Rodolphe , POTIER, Pierre, Jean-Paul , SIEGHART, Werner , JURSKY, Frantisek , FURTMULLER, Roman , SIGEL, Erwin , THOMET, Urs
IPC分类号： C07D405/04 , C07D409/04 , C07D401/04 , A61K31/4725 , A61P25/00
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04
摘要： The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; groups R', identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R'' represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating η-amino-butyric acid activity and as medicine for treating nervous disorders.
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3.发明授权3-AMINO-2,2-DI-C-ALKYL-1,4-BUTYROLACTONES ET 1,4-THIOBUTYROLACTONES N-SUBSTITUEES UTILES COMME STIMULANT DE L'ACTIVITE DE L'ACIDE $g(g)-AMINOBUTYRIQUE ET DANS LE TRAITEMENT DES TROUBLES NERVEUX ET LEUR PROCEDE DE PREPARATION 有权3-氨基-2,2--DI-C-烷基-1,4-丁内酯和N-取代的1,4-硫代丁内酯伽玛AMINOBUTANSÄUREAKTIVITÄT步伐和神经障碍的治疗中使用FIND，AND METHOD FOR PRODUCING
公开(公告)号：EP1226133B1
公开(公告)日：2004-04-07
申请号：EP00969660.0
申请日：2000-10-20
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) , Université de Bern
发明人： DODD, Robert , EL HADRI, Ahmed , POTIER, Pierre, Jean-Paul , SIEGHART, Werner , JURSKY, Frantisek , FURTMULLER, Roman , SIGEL, Erwin , THOMET, Urs
IPC分类号： C07D307/33 , A61K31/365 , A61P25/00 , A61P25/08 , A61P25/22
CPC分类号： C07D307/33 , A61K31/365
摘要： The invention concerns compounds represented by general formula (I) wherein: Z represents a sulphur or oxygen atom; the groups R1 and R2, identical or different, represent each an alkyl group or an alkenyl group; X represents a CO, a CO2, an SO or and SO2 and the group R represents an alkyl, aryl, alkenyl or aralkyl group, provided that when Z represents an oxygen atom, X an SO2 and R a group (a), R1 and R2 do not both represent the methyl group. The invention also concerns methods for preparing said compounds, pharmaceutical compositions containing them and their use as promoter of η-aminobutyric acid and as medicine particularly designed for treating nervous disorders.
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4.发明授权1-(BUTYROLACTONE)-ISOQUINOLINES N-SUBSTITUEES POUR LE TRAITEMENT DES TROUBLES NERVEUX 有权N-取代的1-（丁内酯）-ISOCHINOLINE神经障碍的治疗
公开(公告)号：EP1224182B1
公开(公告)日：2003-07-16
申请号：EP00969659.2
申请日：2000-10-20
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Innovationsagentur GmbH bu Technology Marketing Austria (TECMA) , UNIVERSITE DE BERNE
发明人： DODD, Robert , RAZET, Rodolphe , POTIER, Pierre, Jean-Paul , SIEGHART, Werner , JURSKY, Frantisek , FURTMULLER, Roman , SIGEL, Erwin , THOMET, Urs
IPC分类号： C07D405/04 , C07D409/04 , C07D401/04 , A61K31/4725 , A61P25/00
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04
摘要： The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; groups R', identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R'' represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating η-amino-butyric acid activity and as medicine for treating nervous disorders.
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