摘要:
A recombinant Herpesvirus capable of effectively expressing the target alien protein in a host animal which has been inoculated therewith and exerting an excellent immunological effect. The recombinant Herpesvirus has an alien gene expression cassette integrated thereinto wherein a gB gene originating in Herpesvirus (a gene homologous with Herpes simplex virus gB gene) promoter is employed as a promoter for the expression of the alien gene.
摘要:
It is intended to provide a mutant of a surface protective antigen SpaA protein of Erysipelothrix rhusiopathiae or a shortened SpaA protein (DeltaSpaA) obtained by removing a part therefrom and a process for producing the same. By introducing an amino acid substituent into a definite position of the amino acid sequence of the SpaA protein or the DeltaSpaA protein, a mutant of the SpaA protein or the DeltaSpaA protein having immunogenicity and being expressed as an inclusion body in Escherichia coli can be obtained. Because of being expressed as an insoluble inclusion body in Escherichia coli, the above-described mutant of the SpaA protein or the DeltaSpaA protein can be easily collected and purified.
摘要:
A vaccine composition for birds comprising as an active ingredient a structure containing 0-antigen derived from Gram-negative bacteria, provided that said structure does not contain a whole cell, and a process for preparing the same are provided. By using a structure containing 0-antigen (e.g. lipopolysaccharide) derived from Gram-negative bacteria as an active ingredient in accordance with the present invention, alleviation of inoculation reaction and reduction in an amount of injection are attained as compared to the conventional whole -cells vaccine to thereby allow for the increase in the number of other antigens to be mixed therewith.