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公开(公告)号：EP1640009A1
公开(公告)日：2006-03-29
申请号：EP05016659.4
申请日：1994-08-02
IPC分类号： A61K31/56 , C07J41/00 , C07J31/00 , C07J13/00 , C07J9/00 , C07J5/00 , C07J7/00 , C07J63/00 , C07J1/00
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The application discloses methods of making medicaments for treating mammalian diseases characterised by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of general formulae found above in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
摘要翻译： 本申请公开了通过以足以抑制细胞有丝分裂的剂量施用包括秋水仙素或考布司他汀A-4结构基序的雌二醇衍生物来治疗以异常细胞有丝分裂为特征的哺乳动物疾病的药物的方法。 该申请公开了用于该方法的新化合物。
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2.发明公开2-Methoxyestradiol for the treatment of inflammatory disorders 失效2-Methoxyestradiol zur Behandlung vonentzündlichenErkrankungen
公开(公告)号：EP1927359A2
公开(公告)日：2008-06-04
申请号：EP08002915.0
申请日：1994-08-02
IPC分类号： A61K31/56 , C07J41/00 , C07J31/00 , C07J13/00 , C07J9/00 , C07J5/00 , C07J7/00 , C07J63/00 , C07J1/00
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The applications discloses the treatment of inflammatory disorders, in particular those associated with rheumatoid, arthritis, gout, gouty arthritis and Behcet's syndrome, with 2-methoxyestradiol.
摘要翻译： 应用公开了用2-甲氧基雌二醇治疗炎症性疾病，特别是与类风湿，关节炎，痛风，痛风性关节炎和白塞氏综合征相关的炎性疾病。
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公开(公告)号：EP1640009B1
公开(公告)日：2008-10-15
申请号：EP05016659.4
申请日：1994-08-02
IPC分类号： A61K31/56 , C07J41/00 , C07J31/00 , C07J13/00 , C07J9/00 , C07J5/00 , C07J7/00 , C07J63/00 , C07J1/00
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
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公开(公告)号：EP1927359A3
公开(公告)日：2008-06-11
申请号：EP08002915.0
申请日：1994-08-02
IPC分类号： A61K31/56 , C07J41/00 , C07J31/00 , C07J13/00 , C07J9/00 , C07J5/00 , C07J7/00 , C07J63/00 , C07J1/00
CPC分类号： A61K31/567 , A61K31/05 , A61K31/27 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/59 , C07J1/00 , C07J1/0059 , C07J1/007 , C07J1/0096 , C07J5/00 , C07J7/00 , C07J9/00 , C07J13/00 , C07J31/00 , C07J41/00 , C07J63/00 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/899 , Y10S514/912 , Y10S514/914
摘要： The applications discloses the treatment of inflammatory disorders, in particular those associated with rheumatoid, arthritis, gout, gouty arthritis and Behcet's syndrome, with 2-methoxyestradiol.
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