公开(公告)号：EP1001032A3

公开(公告)日：2005-02-23

申请号：EP99121015.4

申请日：1990-08-17

申请人： CHIRON CORPORATION

发明人： Gruber, Harry, E. ,  Jolly, Douglas J. ,  Respess, James G. ,  Laikind, Paul K. ,  Chang, Stephen M. ,  Chada, Sunil D. ,  Warner, John F. ,  Barber, Jack R. ,  St. Louis, Daniel C.

IPC分类号： C12N15/867 ,  A61K48/00

CPC分类号： C12N15/86 ,  A01K2217/05 ,  A01K2267/03 ,  A61K35/13 ,  A61K39/0011 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/57 ,  C12N9/1211 ,  C12N2740/13022 ,  C12N2740/13023 ,  C12N2740/13043 ,  C12N2740/16023 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates to replication-defective recombinant retrovirus capable of infecting human cells and carrying a vector construct which is capable of directing the expression of both: a. an MHC protein or modified form thereof and b. an antigen which is not an MHC protein or modified form thereof, said MHC protein or modified form thereof in cells infected with said retrovirus within a human or animal body being capable of presenting said antigen or a portion thereof so as to stimulate a cell-mediated immune response.

公开(公告)号：EP1001032A2

公开(公告)日：2000-05-17

申请号：EP99121015.4

申请日：1990-08-17

申请人： CHIRON CORPORATION

发明人： Gruber, Harry, E. ,  Jolly, Douglas J. ,  Respess, James G. ,  Laikind, Paul K. ,  Chang, Stephen M. ,  Chada, Sunil D. ,  Warner, John F. ,  Barber, Jack R. ,  St. Louis, Daniel C.

IPC分类号： C12N15/86 ,  C12N15/00 ,  G01N33/50 ,  A61K39/21 ,  C12N7/00 ,  C12N15/49 ,  C12N15/12 ,  C12N5/00

CPC分类号： C12N15/86 ,  A01K2217/05 ,  A01K2267/03 ,  A61K35/13 ,  A61K39/0011 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/57 ,  C12N9/1211 ,  C12N2740/13022 ,  C12N2740/13023 ,  C12N2740/13043 ,  C12N2740/16023 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates to replication-defective recombinant retrovirus capable of infecting human cells and carrying a vector construct which is capable of directing the expression of both:

a. an MHC protein or modified form thereof and
b. an antigen which is not an MHC protein or modified form thereof,
said MHC protein or modified form thereof in cells infected with said retrovirus within a human or animal body being capable of presenting said antigen or a portion thereof so as to stimulate a cell-mediated immune response.

摘要翻译： 本发明涉及能够感染人类细胞并携带能够引导两者表达的载体构建体的复制缺陷型重组逆转录病毒：a。 MHC蛋白或其修饰形式，和b。 不是MHC蛋白或其修饰形式的抗原，所述MHC蛋白或其修饰形式在人或动物体内感染所述逆转录病毒的细胞中能够呈递所述抗原或其部分以刺激细胞介导的 免疫反应。

公开(公告)号：EP0845537A1

公开(公告)日：1998-06-03

申请号：EP97121051.3

申请日：1990-08-17

申请人： CHIRON CORPORATION

发明人： Gruber, Harry E. ,  Jolly, Douglas J. ,  Respess, James G. ,  Laikind, Paul K. ,  Chang, Stephen M. ,  Chada, Sunil D. ,  Warner, John ,  Barber, Jack R. ,  St. Louis, Daniel C.

IPC分类号： C12N15/86 ,  A61K48/00

CPC分类号： C12N15/86 ,  A01K2217/05 ,  A01K2267/03 ,  A61K35/13 ,  A61K39/0011 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/57 ,  C12N9/1211 ,  C12N2740/13022 ,  C12N2740/13023 ,  C12N2740/13043 ,  C12N2740/16023 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates to replication-defective recombinant retroviruses for therapeutic use. In particular, it relates to use of replication-defective recombinant retroviruses carrying a vector construct capable of expressing in human cells an enzyme which converts an agent with little or no cytotoxicity into a cytotoxic agent in the treatment of graft vs host disease.

摘要翻译： 本发明涉及用于治疗用途的复制缺陷型重组逆转录病毒。 特别地，本发明涉及携带能够在人类细胞中表达转化具有很少或没有细胞毒性的药剂转化为细胞毒性剂的药物的载体构建体的复制缺陷型重组逆转录病毒在治疗移植物抗宿主病方面的用途。