公开(公告)号：EP1011813A1

公开(公告)日：2000-06-28

申请号：EP98948171.8

申请日：1998-09-11

申请人： Cook Incorporated ,  MED INSTITUTE, INC. ,  Apple, Marc G.

发明人： APPLE, Marc, G. ,  BATES, Brian, L. ,  DEFORD, John, A. ,  FEARNOT, Neal, E.

IPC分类号： A61N5/10 ,  A61N5/00

CPC分类号： A61M25/1011 ,  A61M2025/1047 ,  A61M2025/1072 ,  A61N5/1002 ,  A61N5/1048

摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons travelling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

公开(公告)号：EP1042030A2

公开(公告)日：2000-10-11

申请号：EP98960455.8

申请日：1998-12-01

申请人： Cook Incorporated ,  MED INSTITUTE, INC.

发明人： APPLE, Marc, G. ,  BATES, Brian, L. ,  DEFORD, John, A. ,  FEARNOT, Neal, E. ,  PURDY, James, D.

IPC分类号： A61M36/06 ,  A61N5/10

CPC分类号： A61M25/10182 ,  A61M25/10185 ,  A61N5/1002 ,  A61N2005/1021

摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).

公开(公告)号：EP1035895A1

公开(公告)日：2000-09-20

申请号：EP98960644.7

申请日：1998-12-02

申请人： Cook Incorporated ,  MED INSTITUTE, INC.

发明人： APPLE, Marc, G. ,  BATES, Brian, L. ,  DEFORD, John, A. ,  FEARNOT, Neal, E.

IPC分类号： A61N5/10

CPC分类号： A61N5/1002 ,  A61N2005/1021

摘要： A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers for transporting the radioactive carrier material, and a plurality of discrete chambers enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise one unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling towards the lumen wall. A radiation dosimetry unit indicator is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.