公开(公告)号：EP1011813A1

公开(公告)日：2000-06-28

申请号：EP98948171.8

申请日：1998-09-11

申请人： Cook Incorporated ,  MED INSTITUTE, INC. ,  Apple, Marc G.

发明人： APPLE, Marc, G. ,  BATES, Brian, L. ,  DEFORD, John, A. ,  FEARNOT, Neal, E.

IPC分类号： A61N5/10 ,  A61N5/00

CPC分类号： A61M25/1011 ,  A61M2025/1047 ,  A61M2025/1072 ,  A61N5/1002 ,  A61N5/1048

摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons travelling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

公开(公告)号：EP1042030A2

公开(公告)日：2000-10-11

申请号：EP98960455.8

申请日：1998-12-01

申请人： Cook Incorporated ,  MED INSTITUTE, INC.

发明人： APPLE, Marc, G. ,  BATES, Brian, L. ,  DEFORD, John, A. ,  FEARNOT, Neal, E. ,  PURDY, James, D.

IPC分类号： A61M36/06 ,  A61N5/10

CPC分类号： A61M25/10182 ,  A61M25/10185 ,  A61N5/1002 ,  A61N2005/1021

摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).

公开(公告)号：EP1035895A1

公开(公告)日：2000-09-20

申请号：EP98960644.7

申请日：1998-12-02

申请人： Cook Incorporated ,  MED INSTITUTE, INC.

发明人： APPLE, Marc, G. ,  BATES, Brian, L. ,  DEFORD, John, A. ,  FEARNOT, Neal, E.

IPC分类号： A61N5/10

CPC分类号： A61N5/1002 ,  A61N2005/1021

摘要： A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers for transporting the radioactive carrier material, and a plurality of discrete chambers enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise one unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling towards the lumen wall. A radiation dosimetry unit indicator is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

公开(公告)号：EP0971646B1

公开(公告)日：2004-09-22

申请号：EP98918112.8

申请日：1998-04-09

申请人： WILLIAM COOK, EUROPE A/S ,  Cook Incorporated

发明人： PAPAZOGLOU, Konstantinos ,  DEBRUYNE, Michael, P. ,  DEFORD, John, A. ,  RASMUSSEN, Erik, E.

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/8483 ,  A61F2220/0075 ,  A61F2230/0034 ,  A61F2230/0067

摘要： This is regarding a type of device aimed at a simpler, in relation to already existing techniques, endovascular positioning of a stent-graft in the abdominal aorta for the therapy of aneurysms up to the point of its bifurcation (26). This device is comprised of a system of three cylinders: a 'main' (1) centrally placed and two 'limbs' (4, 5) peripherally placed. Each of these cylinders has a central (14, 9, 8) and a peripheral (12, 10, 11) orifice. The cylinders are comprised of a cylindrical metallic skeleton which is self-expanding (2, 7) and made out of stainless steel or nitinol and which is externally covered with a cylinder (3, 8) made out of thin-layered PTFE, Dacron or some other elastic biocompatible material, refolded (18) around the peripheral orifice (12) of the skeleton of the main cylinder. These cylinders can be compressed into small diameter tubules (23, 27, 38) and enter the vascular lumen. After their insertion into the desired position, they expand, regaining their original diameter. The main cylinder (1) is placed inside the aorta becoming more circular when it comes in contact with the healthy part of the aorta (13) central to the aneurysm at the center of the orifice (14). The peripheral orifice of the main cylinder sits upon the expanded aortic bifurcation (26). The two limbs have a central orifice (8, 9) with a diameter equal to or approximately about 2 mm smaller than the diameter of the peripheral orifice (12) of the main cylinder. The branching of the main cylinder is accomplished by the entrance of the main ends of the two limbs inside the peripheral end of the main cylinder. Both limbs are at the same height in such a manner that they compress each other at the center of the cylinder. Each limb exerts equal pressure, whereas equal pressure is also exerted on the internal surface of the main cylinder from their external surface (FIG. 5) and together they both occupy at the height of their orifices the entire perimeter of the main cylinder (43). Alternatively, as limbs (peripheral cylinders), tubes of different diameters and types of skeletons can be used (28, 27).

公开(公告)号：EP0971646A1

公开(公告)日：2000-01-19

申请号：EP98918112.8

申请日：1998-04-09

申请人： WILLIAM COOK, EUROPE A/S ,  Cook Incorporated

发明人： KONSTANTINOS, Papazoglou, O. ,  DEBRUYNE, Michael, P. ,  DEFORD, John, A. ,  RASMUSSEN, Erik, E.

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/8483 ,  A61F2220/0075 ,  A61F2230/0034 ,  A61F2230/0067

摘要： This is regarding a type of device aimed at a simpler, in relation to already existing techniques, endovascular positioning of a stent-graft in the abdominal aorta for the therapy of aneurysms up to the point of its bifurcation (26). This device is comprised of a system of three cylinders: a 'main' (1) centrally placed and two 'limbs' (4, 5) peripherally placed. Each of these cylinders has a central (14, 9, 8) and a peripheral (12, 10, 11) orifice. The cylinders are comprised of a cylindrical metallic skeleton which is self-expanding (2, 7) and made out of stainless steel or nitinol and which is externally covered with a cylinder (3, 8) made out of thin-layered PTFE, Dacron or some other elastic biocompatible material, refolded (18) around the peripheral orifice (12) of the skeleton of the main cylinder. These cylinders can be compressed into small diameter tubules (23, 27, 38) and enter the vascular lumen. After their insertion into the desired position, they expand, regaining their original diameter. The main cylinder (1) is placed inside the aorta becoming more circular when it comes in contact with the healthy part of the aorta (13) central to the aneurysm at the center of the orifice (14). The peripheral orifice of the main cylinder sits upon the expanded aortic bifurcation (26). The two limbs have a central orifice (8, 9) with a diameter equal to or approximately about 2 mm smaller than the diameter of the peripheral orifice (12) of the main cylinder. The branching of the main cylinder is accomplished by the entrance of the main ends of the two limbs inside the peripheral end of the main cylinder. Both limbs are at the same height in such a manner that they compress each other at the center of the cylinder. Each limb exerts equal pressure, whereas equal pressure is also exerted on the internal surface of the main cylinder from their external surface (FIG. 5) and together they both occupy at the height of their orifices the entire perimeter of the main cylinder (43). Alternatively, as limbs (peripheral cylinders), tubes of different diameters and types of skeletons can be used (28, 27).

公开(公告)号：EP1251805B1

公开(公告)日：2007-03-28

申请号：EP01910431.4

申请日：2001-02-05

申请人： Cook Incorporated ,  Cook Biotech, Inc.

发明人： PAVCNIK, Dusan ,  KELLER, Frederick, S. ,  ROSCH, Josef ,  OSBORNE, Thomas, A. ,  BATES, Brian, L. ,  DEFORD, John, A. ,  DIXON, Christopher, G. ,  HOFFA, Andrew, K. ,  LEONARD, Raymond, B., II ,  OBERMILLER, Joseph, F.

IPC分类号： A61F2/24 ,  A61B17/12 ,  A61F2/06

CPC分类号： A61B17/12022 ,  A61B17/12172 ,  A61F2/01 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2002/018 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0023 ,  A61F2230/0026 ,  A61F2230/005 ,  A61F2230/0058 ,  A61F2230/0095

摘要： A multiple-sided medical device (10) comprises a frame (11) comprising wire or other resilient material and having a series of bends (12) and interconnecting sides. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs (16) for anchoring purposes. A full or partial covering (45) of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device (51), a stent graft (75), or an implantable, intraluminal valve (43) such as for correcting incompetent veins in the lower legs and feet.

公开(公告)号：EP1251805A2

公开(公告)日：2002-10-30

申请号：EP01910431.4

申请日：2001-02-05

申请人： Cook Incorporated ,  Cook Biotech, Inc.

发明人： PAVCNIK, Dusan ,  KELLER, Frederick, S. ,  ROSCH, Josef ,  OSBORNE, Thomas, A. ,  BATES, Brian, L. ,  DEFORD, John, A. ,  DIXON, Christopher, G. ,  HOFFA, Andrew, K. ,  LEONARD, Raymond, B., II ,  OBERMILLER, Joseph, F. ,  OSBORNE, Thomas, A.

IPC分类号： A61F2/24 ,  A61B17/12 ,  A61F2/06

CPC分类号： A61B17/12022 ,  A61B17/12172 ,  A61F2/01 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2002/018 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0023 ,  A61F2230/0026 ,  A61F2230/005 ,  A61F2230/0058 ,  A61F2230/0095

摘要： A multiple-sided medical device (10) comprises a frame (11) comprising wire or other resilient material and having a series of bends (12) and interconnecting sides. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs (16) for anchoring purposes. A full or partial covering (45) of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device (51), a stent graft (75), or an implantable, intraluminal valve (43) such as for correcting incompetent veins in the lower legs and feet.