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公开(公告)号：EP1131321B1
公开(公告)日：2003-09-10
申请号：EP99972634.2
申请日：1999-11-18
IPC分类号： C07D417/14 , C07D401/14 , A61K31/549 , A61K31/5415 , A61K31/475 , A61K31/454 , C07D285/16 , C07D285/10 , C07D215/22 , C07D215/36 , C07D209/34
CPC分类号： C07D215/227 , C07D209/34 , C07D215/36 , C07D285/10 , C07D285/16 , C07D401/14 , C07D417/14
摘要： A pharmaceutical compound of formula (I) in which R?1 and R2¿ are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, X is (1) or (2), Y is (3) or (4) where R?4 and R5¿ are each hydrogen, C¿1-6? alkyl, cyclopropyl or cyclopropyl-C1-6 alkyl, n is 0 or 1, and R?3 is -SR6, -SOR6, -SO¿2R?6, -COR6, -CH¿2OH or -CONHR7, where R6 is C¿1-6? alkyl and R?7¿ is hydrogen or C¿1-6? alkyl; provided that when one of R?1 and R2¿ is hydrogen and the other is fluoro, X is (1), Y is (4), R?4 and R5¿ are each hydrogen or C¿1-6? alkyl, and n is 0, then R?3¿ is not -COR6 or -CONHR7; and salts thereof.
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公开(公告)号：EP1131321A2
公开(公告)日：2001-09-12
申请号：EP99972634.2
申请日：1999-11-18
IPC分类号： C07D417/14 , C07D401/14 , A61K31/549 , A61K31/5415 , A61K31/475 , A61K31/454 , C07D285/16 , C07D285/10 , C07D215/22 , C07D215/36 , C07D209/34
CPC分类号： C07D215/227 , C07D209/34 , C07D215/36 , C07D285/10 , C07D285/16 , C07D401/14 , C07D417/14
摘要： A pharmaceutical compound of formula (I) in which R?1 and R2¿ are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, X is (1) or (2), Y is (3) or (4) where R?4 and R5¿ are each hydrogen, C¿1-6? alkyl, cyclopropyl or cyclopropyl-C1-6 alkyl, n is 0 or 1, and R?3 is -SR6, -SOR6, -SO¿2R?6, -COR6, -CH¿2OH or -CONHR7, where R6 is C¿1-6? alkyl and R?7¿ is hydrogen or C¿1-6? alkyl; provided that when one of R?1 and R2¿ is hydrogen and the other is fluoro, X is (1), Y is (4), R?4 and R5¿ are each hydrogen or C¿1-6? alkyl, and n is 0, then R?3¿ is not -COR6 or -CONHR7; and salts thereof.
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3.发明授权4-AMINO-PIPERIDINE DERIVATIVES AS MONOAMINE UPTAKE INHIBITORS 有权4- AMINOPIPERIDINDERIVATE AS MONO AMIN记录抑制剂
公开(公告)号：EP1735302B1
公开(公告)日：2010-06-16
申请号：EP05722890.0
申请日：2005-02-11
发明人： BOULET, Serge, Louis , CLARK, Barry, Peter , FAIRHURST, John , GALLAGHER, Peter, Thaddeus , JOHANSSON, Anette, Margareta , WHATTON, Maria, Ann , WOOD, Virginia, Ann
IPC分类号： C07D409/12 , C07D405/12 , C07D401/12 , C07D417/12 , C07D513/04 , A61K31/435 , A61P25/00
CPC分类号： C07D513/04 , A61K31/454 , A61K31/4545 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.
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公开(公告)号：EP1735302A1
公开(公告)日：2006-12-27
申请号：EP05722890.0
申请日：2005-02-11
发明人： BOULET, Serge, Louis , CLARK, Barry, Peter , FAIRHURST, John , GALLAGHER, Peter, Thaddeus , JOHANSSON, Anette, Margareta , WHATTON, Maria, Ann , WOOD, Virginia, Ann
IPC分类号： C07D409/12 , C07D405/12 , C07D401/12 , C07D417/12 , C07D513/04 , A61K31/435 , A61P25/00
CPC分类号： C07D513/04 , A61K31/454 , A61K31/4545 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.
摘要翻译： 本发明提供了式（I）的化合物，其中n，R 1，R 2，R 3，R 4，R 5和杂芳基如本文所定义。 所述化合物是一种或多种选自5-羟色胺，去甲肾上腺素和多巴胺的单胺的摄取抑制剂，因此可用于治疗中枢和/或外周神经系统的病症。
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