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公开(公告)号：EP2307457B1
公开(公告)日：2018-06-13
申请号：EP09768692.7
申请日：2009-06-25
发明人： BORRAS, Leonardo , GUNDE, Tea , URECH, David
IPC分类号： C07K16/24 , A61K39/395 , C12N15/13
CPC分类号： C07K16/241 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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公开(公告)号：EP3216803A1
公开(公告)日：2017-09-13
申请号：EP17151756.8
申请日：2009-06-25
发明人： BORRAS, Leonardo , URECH, David , GUNDE, Tea
IPC分类号： C07K16/22 , A61K39/395
摘要： The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
摘要翻译： 本发明涉及包含来自兔单克隆抗体的CDR的可溶且稳定的抗VEGF免疫结合剂。 所述抗体被设计用于诊断和/或治疗VEGF介导的病症。 还公开了用于表达本发明的重组抗体的杂交瘤，核酸，载体和宿主细胞，分离它们的方法以及所述抗体在医学中的用途。
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公开(公告)号：EP2307458A2
公开(公告)日：2011-04-13
申请号：EP09768695.0
申请日：2009-06-25
发明人： BORRAS, Leonardo , URECH, David
IPC分类号： C07K16/24 , C07K16/22 , A61K39/395 , C12N15/13
CPC分类号： C07K16/18 , A61K39/3955 , A61K39/39558 , A61K47/6877 , C07K16/22 , C07K16/241 , C07K16/30 , C07K16/465 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
摘要翻译： 本发明涉及到通用抗体受体构架和用于接枝非人抗体，E. G.，兔抗体，使用通用抗体受体构架的方法。 通过本发明的方法产生的抗体可用于多种诊断和治疗应用。
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公开(公告)号：EP2321354B2
公开(公告)日：2019-11-20
申请号：EP10705086.6
申请日：2010-02-22
IPC分类号： C07K16/28 , C12N5/0781 , C12N15/13 , G01N33/537
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公开(公告)号：EP2303230A2
公开(公告)日：2011-04-06
申请号：EP09775745.4
申请日：2009-07-10
CPC分类号： A61K47/183 , A61K9/0043 , A61K9/08 , A61K39/3955 , A61K2039/505 , A61K2039/543 , C07K16/241 , C07K2317/24 , C07K2317/622 , Y02P20/55 , A61K2300/00
摘要： The invention provides compositions and methods that enhance the delivery of large macromolecules (i.e., greater than 10kDa), such as antigen-binding polypeptides, across tight junctions. Such methods and compositions are particularly useful for delivering therapeutic antigen-binding polypeptides to the CNS, via intranasal administration, for the treatment of neurological disorders.
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公开(公告)号：EP2307455B1
公开(公告)日：2017-03-22
申请号：EP09768694.3
申请日：2009-06-25
发明人： BORRAS, Leonardo , URECH, David
CPC分类号： C07K16/241 , C07K16/22 , C07K2317/567 , C07K2317/622 , C07K2317/94
摘要： The invention provides methods of using sequence based analysis and rational strategies to improve the solubility of immunobinders, and in particular of single chain antibodies (scFvs). The invention provides methods of engineering immunobinders, and in particular scFvs, by performing one or more substitutions with hydrophilic residues identified by analysis of a database of selected, stable scFv sequences. The invention also provides immunobinders with optimized solubility prepared according to the engineering methods of the invention.
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公开(公告)号：EP2321354B1
公开(公告)日：2016-12-07
申请号：EP10705086.6
申请日：2010-02-22
IPC分类号： C07K16/28 , C12N5/0781 , C12N15/13 , G01N33/537
摘要： The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.
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8.发明授权
公开(公告)号：EP2158315B1
公开(公告)日：2016-03-23
申请号：EP08757278.0
申请日：2008-06-25
发明人： URECH, David , BORRAS, Leonardo
IPC分类号： C12N15/09 , A61K39/395 , C12N15/13 , C07K16/00
CPC分类号： C07K16/241 , C07K2317/567 , C07K2317/622
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公开(公告)号：EP2307457A2
公开(公告)日：2011-04-13
申请号：EP09768692.7
申请日：2009-06-25
发明人： BORRAS, Leonardo , GUNDE, Tea , URECH, David
IPC分类号： C07K16/24 , A61K39/395 , C12N15/13
CPC分类号： C07K16/241 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNF-mediated disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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公开(公告)号：EP3628686A1
公开(公告)日：2020-04-01
申请号：EP19208570.2
申请日：2009-06-25
发明人： BORRAS, Leonardo , URECH, David
摘要： The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
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