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1.发明授权PROCESS FOR THE MANUFACTURE OF (SUB)MICRON SIZED PARTICLES BY DISSOLVING IN COMPRESSED GAS AND SURFACTANTS 有权过程不到大测微颗粒的制备爆破成气体压力和表面活性物质
公开(公告)号：EP1071402B1
公开(公告)日：2006-09-13
申请号：EP99919195.0
申请日：1999-04-06
发明人： BAUSCH, Alexander , HIDBER, Pirmin
CPC分类号： B01F3/1214 , A61K9/14 , A61K9/145 , A61K9/1688 , B01F3/1271 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J2/04 , B01J3/008 , B01J13/02 , Y02P20/544 , Y10S977/906
摘要： The present invention relates to a process for manufacturing a pulverous preparation of a (sub)micron-sized biologically active compound comprising the steps of: (1) dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; or in compressed dimethylether optionally containing a surface modifier; (2a) rapidly expanding the compressed solution of step (1) thereby precipitating the dissolved compound; or (2b) spraying the compressed solution of step (1) into an antisolvant phase optionally containing a surface modifier under vacuum, atmospheric pressure or elevated pressure; and (3) optionally converting the antisolvant phase of step (2b) into a pulverous preparation using conventional powder processing techniques. With the process according to the present invention formation of aggregations or flocculations of particles dissolved in the supercritical solution is prevented; moreover, the addition of cosolvents is not required, thus increasing the stabilisation of the suspension on an industrial scale.
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2.发明公开
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公开(公告)号：EP2906566B1
公开(公告)日：2016-08-24
申请号：EP13774174.0
申请日：2013-10-09
发明人： BABU, Srinivasan , CHENG, Zhigang , GOSSELIN, Francis , HIDBER, Pirmin , HOFFMANN, Ursula , HUMPHRIES, Theresa , REENTS, Reinhard , TIAN, Qingping , YAJIMA, Herbert
IPC分类号： C07D495/04 , A61K31/519
CPC分类号： C07D495/04 , C07D295/185
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4.发明公开PROCESS FOR THE MANUFACTURE OF (SUB)MICRON SIZED PARTICLES BY DISSOLVING IN COMPRESSED GAS AND SURFACTANTS 有权过程不到大测微颗粒的制备爆破成气体压力和表面活性物质
公开(公告)号：EP1071402A1
公开(公告)日：2001-01-31
申请号：EP99919195.0
申请日：1999-04-06
发明人： BAUSCH, Alexander , HIDBER, Pirmin
CPC分类号： B01F3/1214 , A61K9/14 , A61K9/145 , A61K9/1688 , B01F3/1271 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J2/04 , B01J3/008 , B01J13/02 , Y02P20/544 , Y10S977/906
摘要： The present invention relates to a process for manufacturing a pulverous preparation of a (sub)micron-sized biologically active compound comprising the steps of: (1) dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; or in compressed dimethylether optionally containing a surface modifier; (2a) rapidly expanding the compressed solution of step (1) thereby precipitating the dissolved compound; or (2b) spraying the compressed solution of step (1) into an antisolvant phase optionally containing a surface modifier under vacuum, atmospheric pressure or elevated pressure; and (3) optionally converting the antisolvant phase of step (2b) into a pulverous preparation using conventional powder processing techniques. With the process according to the present invention formation of aggregations or flocculations of particles dissolved in the supercritical solution is prevented; moreover, the addition of cosolvents is not required, thus increasing the stabilisation of the suspension on an industrial scale.
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5.发明公开POLYMORPH OF {6,7-BIS(2-METHOXY-ETHOXY)-QUINAZOLIN-4-YL}-(3E) 有权的多晶型{6,7-双（2-甲氧基乙氧基）喹唑啉-4-基} - （3E）
公开(公告)号：EP1597239A1
公开(公告)日：2005-11-23
申请号：EP04710031.8
申请日：2004-02-11
发明人： BUBENDORF, André, Gerard , HENNIG, Michael , HIDBER, Pirmin , RIMMLER, Goesta , ROHRER, Franziska
IPC分类号： C07D239/94 , A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , C07D239/94
摘要： The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride and can be used as medicament for the treatment of hyperproliferative disorders.
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公开(公告)号：EP3496722A1
公开(公告)日：2019-06-19
申请号：EP17749706.2
申请日：2017-08-09
发明人： REENTS, Reinhard , HIDBER, Pirmin , HELL, André , STEIDLE, Peter , WUNDERLICH, Martin , PEPELNJAK, Marie , GOSSELIN, Francis , YOST, Edward
IPC分类号： A61K31/517 , A61K9/20 , A61K9/28 , A61P35/00
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7.发明授权POLYMORPH OF {6,7-BIS(2-METHOXY-ETHOXY)-QUINAZOLIN-4-YL}-(3E) 有权的多晶型{6,7-双（2-甲氧基乙氧基）喹唑啉-4-基} - （3E）
公开(公告)号：EP1597239B1
公开(公告)日：2008-09-17
申请号：EP04710031.8
申请日：2004-02-11
发明人： BUBENDORF, André, Gerard , HENNIG, Michael , HIDBER, Pirmin , RIMMLER, Goesta , ROHRER, Franziska
IPC分类号： C07D239/94 , A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , C07D239/94
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