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公开(公告)号：EP1924264B9
公开(公告)日：2014-02-19
申请号：EP06778331.6
申请日：2006-08-23
发明人： BROKA, Chris Allen , CARTER, David Scott , DILLON, Michael Patrick , FORD, Anthony P.D.W. , HAWLEY, Ronald Charles , JAHANGIR, Alam , MOORE, Amy Geraldine , PARISH, Daniel Warren
IPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61P11/00 , A61P11/06 , A61P1/00
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
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公开(公告)号：EP1924264B1
公开(公告)日：2013-09-18
申请号：EP06778331.6
申请日：2006-08-23
发明人： BROKA, Chris Allen , CARTER, David Scott , DILLON, Michael Patrick , FORD, Anthony P.D.W. , HAWLEY, Ronald Charles , JAHANGIR, Alam , MOORE, Amy Geraldine , PARISH, Daniel Warren
IPC分类号： A61K31/505 , A61K31/506 , A61K31/513 , A61P11/00 , A61P11/06 , A61P1/00
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
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公开(公告)号：EP1924264A1
公开(公告)日：2008-05-28
申请号：EP06778331.6
申请日：2006-08-23
发明人： BROKA, Chris Allen , CARTER, David Scott , DILLON, Michael Patrick , FORD, Anthony P.D.W. , HAWLEY, Ronald Charles , JAHANGIR, Alam , MOORE, Amy Geraldine , PARISH, Daniel Warren
IPC分类号： A61K31/505 , A61K31/506 , A61P11/00 , A61P11/06 , A61P1/00
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
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4.发明授权
公开(公告)号：EP2445868B1
公开(公告)日：2013-12-18
申请号：EP10725188.6
申请日：2010-06-18
IPC分类号： C07C237/42 , C07D213/00 , C07D233/00 , C07D241/00 , C07D261/00 , C07D263/00 , C07D265/00 , C07D277/00 , C07D285/00 , C07D307/00 , C07D309/00 , C07D333/00 , C07D231/00 , C07D305/00 , A61K31/166 , A61K31/33
CPC分类号： C07D241/12 , C07C237/32 , C07C237/42 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/56 , C07D213/61 , C07D213/81 , C07D231/14 , C07D241/24 , C07D261/18 , C07D263/34 , C07D265/30 , C07D277/56 , C07D285/06 , C07D295/125 , C07D307/68 , C07D309/08 , C07D333/38 , C07D401/12 , C07D403/12 , C07D405/14 , C07D417/12
摘要： Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted phenyl or optionally substituted pyridinyl, and R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
摘要翻译： 式I化合物或其药学上可接受的盐，其中，R 1是任选取代的苯基或任选取代的吡啶基，且R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如本文所定义。 还公开了使用该化合物治疗与P2X3和/或P2X2 / 3受体拮抗剂相关疾病的方法和制备该化合物的方法。
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公开(公告)号：EP2445868A2
公开(公告)日：2012-05-02
申请号：EP10725188.6
申请日：2010-06-18
IPC分类号： C07C237/42 , C07D213/00 , C07D233/00 , C07D241/00 , C07D261/00 , C07D263/00 , C07D265/00 , C07D277/00 , C07D285/00 , C07D307/00 , C07D309/00 , C07D333/00 , C07D231/00 , C07D305/00 , A61K31/166 , A61K31/33
CPC分类号： C07D241/12 , C07C237/32 , C07C237/42 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/56 , C07D213/61 , C07D213/81 , C07D231/14 , C07D241/24 , C07D261/18 , C07D263/34 , C07D265/30 , C07D277/56 , C07D285/06 , C07D295/125 , C07D307/68 , C07D309/08 , C07D333/38 , C07D401/12 , C07D403/12 , C07D405/14 , C07D417/12
摘要： Compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , and R
8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X
3 and/or a P2X
2/3 receptor antagonists and methods of making the compounds.摘要翻译： 式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义。 还公开了使用所述化合物治疗与P2X 3和/或P2X 2/3受体拮抗剂相关疾病的方法和制备所述化合物的方法。
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