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公开(公告)号：EP2718266B9
公开(公告)日：2016-11-30
申请号：EP12725834.1
申请日：2012-06-07
发明人： BISSANTZ, Caterina , GRETHER, Uwe , HEBEISEN, Paul , KIMBARA, Atsushi , LIU, Qingping , NETTEKOVEN, Matthias , PRUNOTTO, Marco , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja , ULLMER, Christoph , WANG, Zhiwei , YANG, Wulun
IPC分类号： C07D213/81 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107 , A61K31/44 , A61P29/00
CPC分类号： C07D213/81 , C07D213/79 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107
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公开(公告)号：EP2771327B1
公开(公告)日：2016-11-16
申请号：EP12778342.1
申请日：2012-10-25
发明人： BISSANTZ, Caterina , DHURWASULU, Baledi , GRETHER, Uwe , HAZRA, Anindya , HEBEISEN, Paul , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC分类号： C07D241/12 , C07D241/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/497 , A61P9/00
CPC分类号： C07D413/12 , C07D241/12 , C07D241/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/14
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公开(公告)号：EP2718266B1
公开(公告)日：2016-05-25
申请号：EP12725834.1
申请日：2012-06-07
发明人： BISSANTZ, Caterina , GRETHER, Uwe , HEBEISEN, Paul , KIMBARA, Atsushi , LIU, Qingping , NETTEKOVEN, Matthias , PRUNOTTO, Marco , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja , ULLMER, Christoph , WANG, Zhiwei , YANG, Wulun
IPC分类号： C07D213/81 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107 , A61K31/44 , A61P29/00
CPC分类号： C07D213/81 , C07D213/79 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107
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公开(公告)号：EP2964646A1
公开(公告)日：2016-01-13
申请号：EP14709590.5
申请日：2014-03-04
发明人： GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , RICKLIN, Fabienne , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja
IPC分类号： C07D471/04 , C07D487/04 , C07D473/04
CPC分类号： A61K31/519 , C07D471/04 , C07D473/04 , C07D487/04
摘要： The invention relates to a compound of formula (I) wherein A
1 to A
3 and R
1 to R
3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.摘要翻译： 其中A1至A3和R1至R3如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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5.发明授权[1, 2, 3]TRIAZOLO [4, 5 -D]PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 有权[1,2,3]三唑并[4,5-D]嘧啶衍生物作为大麻素受体2激动剂
公开(公告)号：EP2776442B1
公开(公告)日：2015-10-21
申请号：EP12780208.0
申请日：2012-11-05
发明人： ADAM, Jean-Michel , BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P9/10 , A61P27/06
CPC分类号： C07D487/04 , A61K9/0019 , A61K9/2054 , A61K9/4866 , A61K31/519 , A61K47/10 , C07D491/107
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公开(公告)号：EP2681210B1
公开(公告)日：2015-10-07
申请号：EP12706041.6
申请日：2012-02-28
IPC分类号： C07D417/12 , C07D513/04 , A61K31/554 , A61P25/16 , A61P3/10
CPC分类号： C07D417/12 , A61K31/554 , C07D513/04
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公开(公告)号：EP2718266A1
公开(公告)日：2014-04-16
申请号：EP12725834.1
申请日：2012-06-07
发明人： BISSANTZ, Caterina , GRETHER, Uwe , HEBEISEN, Paul , KIMBARA, Atsushi , LIU, Qingping , NETTEKOVEN, Matthias , PRUNOTTO, Marco , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja , ULLMER, Christoph , WANG, Zhiwei , YANG, Wulun
IPC分类号： C07D213/81 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107 , A61K31/44 , A61P29/00
CPC分类号： C07D213/81 , C07D213/79 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/107
摘要： The invention relates to a compound of formula (I) wherein R
1 to R
4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.-
公开(公告)号：EP2709992A1
公开(公告)日：2014-03-26
申请号：EP12722112.5
申请日：2012-05-11
发明人： HILPERT, Hans , NARQUIZIAN, Robert , PINARD, Emmanuel , POLARA, Alessandra , ROGERS-EVANS, Mark , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D265/08 , C07D413/10 , C07D413/12 , A61K31/5355 , A61K31/535 , A61P25/28
CPC分类号： C07D413/10 , C07D265/08 , C07D413/12
摘要： The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译： 本发明提供了具有BACE1和/或BACE2抑制活性的式I化合物，它们的制造方法，含有它们的药物组合物以及它们作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默病和2型糖尿病。
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公开(公告)号：EP2509966A1
公开(公告)日：2012-10-17
申请号：EP10790920.2
申请日：2010-12-07
IPC分类号： C07D265/08 , C07D413/12 , C07D417/12 , C07D495/04 , C07D498/04 , A61K31/5355 , A61P3/10
CPC分类号： C07D413/12 , C07D265/08 , C07D417/12 , C07D495/04 , C07D498/04
摘要： This invention relates to 5,6-dihydro-4H-[1,3]oxazin-2-ylamine compounds of the formula (I) wherein R
1 to R
5 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the treatment or prevention of diseases such as diabetes.-
公开(公告)号：EP2099799B1
公开(公告)日：2010-06-02
申请号：EP07847384.0
申请日：2007-11-27
发明人： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC分类号： C07D471/10 , C07D498/10 , A61K31/438 , A61P9/02
CPC分类号： C07D471/10 , C07D498/10
摘要： Present invention is concerned with novel indol-2-yl-carbonyl-spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. The compounds of present invention have the general Formula (I) wherein R1 to R11 and X are as defined in the description.
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