-
1.发明公开METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS 审中-公开VERFAHREN ZUR KREBSBEHANDLUNG MIT PD-1-ACHSENBINDENDEN ANTAGONISTEN UND MEK-INHIBITOREN
公开(公告)号：EP2739358A1
公开(公告)日：2014-06-11
申请号：EP12748808.8
申请日：2012-08-01
发明人： MAECKER, Heather , IRVING, Bryan
IPC分类号： A61P35/00 , A61K39/395 , C07K16/28 , C07K16/30
CPC分类号： A61K39/39558 , A61K31/4184 , A61K31/4355 , A61K31/44 , A61K31/4523 , A61K31/519 , A61K47/62 , A61K47/64 , A61K2039/505 , C07K16/2827 , C07K16/3046 , C07K16/3053 , A61K2300/00
摘要： The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
摘要翻译： 本发明描述了包含PD-1轴结合拮抗剂和MEK抑制剂的组合治疗剂及其使用方法，包括治疗需要增强免疫原性的病症的方法，例如增加用于治疗癌症的肿瘤免疫原性。
-
2.发明公开METHODS OF TREATING HER2-POSITIVE CANCERS USING PD-1 AXIS BINDING ANTAGONISTS AND ANTI-HER2 ANTIBODIES 审中-公开METHOD FOR HER-2阳性的癌症与PD-1结合拮抗剂和抗HER2抗体治疗
公开(公告)号：EP3083692A1
公开(公告)日：2016-10-26
申请号：EP14833308.1
申请日：2014-12-17
发明人： DENNIS, Mark S. , EBENS, Allen , IRVING, Bryan , JUNTTILA, Teemu T. , LI, Ji
IPC分类号： C07K16/28 , A61K31/337
摘要： The invention provides methods and compositions for treating cancer and for enhancing immune function in an individual having cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.
摘要翻译： 本发明提供了用于治疗癌症和用于增强个体在患有癌症的免疫功能的方法和组合物。 所述方法包括施用PD-1轴结合拮抗剂和紫杉烷。
-
3.发明公开METHODS OF TREATING CANCER USING PD-L1 AXIS BINDING ANTAGONISTS AND VEGF ANTAGONISTS 审中-公开用于癌症治疗方法采用PD-L1桥和约束力拮抗剂VEGF拮抗剂
公开(公告)号：EP2855528A1
公开(公告)日：2015-04-08
申请号：EP13729174.6
申请日：2013-05-30
发明人： MAECKER, Heather , IRVING, Bryan
IPC分类号： C07K16/28 , C07K16/22 , A61K39/395
CPC分类号： A61K39/3955 , A61K31/282 , A61K31/513 , A61K31/519 , A61K39/39558 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2827 , A61K2300/00
摘要： The present invention describes combination treatment comprising a PD-1 axis binding antagonist, chemotherapy and optionally a VEGF antagonist and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.
-
4.发明公开ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION 有权抗体-PD-L1抗体在DEREN VERWENDUNG ZUR VERBESSERUNG DER T-ZELLEN-FUNKTION
公开(公告)号：EP2376535A1
公开(公告)日：2011-10-19
申请号：EP09764997.4
申请日：2009-12-08
发明人： IRVING, Bryan , CHEUNG, Jeanne , CHIU, Henry , LEHAR, Sophie, M. , MAECKER, Heather , MARIATHASAN, Sanjeev , WU, Yan
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
CPC分类号： C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/1063 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/492 , A61K2300/00
摘要： The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection ( e.g ., acute and chronic) and tumor immunity.
摘要翻译： 本申请涉及抗PD-L1抗体，编码其的核酸，其治疗组合物及其用途增强T细胞功能以上调细胞介导的免疫应答和治疗T细胞功能障碍性疾病，包括感染（ 例如急性和慢性）和肿瘤免疫。
-
-
-
搜索结果
4 条记录 (耗时 0.028 秒)
