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公开(公告)号：EP0933422A4
公开(公告)日：2005-02-02
申请号：EP97926214
申请日：1997-06-11
发明人： UEDA SATOSHI , TANAKA MIHO , EZAKI MASAMI , SAKAMOTO KAZUTOSHI , HASHIMOTO SEIJI , OOHATA NOBUTAKA , TSUBOI MASARU , YAMASHITA MICHIO
摘要： A cyclic lipopeptide acylase which can effectively remove acyl side chains from cyclic lipopeptides, specifically substances FR901379 of general formula (I) and analogues thereof; and a process for the preparation of cyclic peptides by the use of this acylase, wherein R is acyl; R is hydroxyl or acyloxy; R is H or hydroxyl; R is H or hydroxyl; R is H or hydroxysulfonyloxy; and R is H or carbamoyl.
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公开(公告)号：EP0885957A4
公开(公告)日：2004-06-09
申请号：EP97905455
申请日：1997-03-06
发明人： UEDA SATOSHI , TANAKA MIHO , EZAKI MASAMI , SAKAMOTO KAZUTOSHI , HASHIMOTO SEIJI , OOHATA NOBUTAKA , TSUBOI MASARU , YAMASHITA MICHIO
摘要： A cyclic lipopeptide acylase which can effectively remove an acyl side chain from a cyclic lipopeptide, specifically FR901379 represented by general formula (I) or an analogue thereof; and a process for the preparation of a cyclic peptide with the acylase, wherein R1 is acyl, R2 is hydroxy or acyloxy, R3 is hydrogen or hydroxy, R4 is hydrogen or hydroxy, R5 is hydrogen or hydroxysulfonyloxy, and R6 is hydrogen or carbamoyl.
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公开(公告)号：EP0943689A4
公开(公告)日：2000-12-20
申请号：EP97909655
申请日：1997-10-28
CPC分类号： C12P17/188 , Y10S435/929
摘要： A process for preparing compounds represented by general formula (I), wherein R represent hydrogen, a lower alkanoyl group or a lower alkyl group; and R and R represent each hydrogen or a lower alkanoyl group, characterized by reacting a culture of a strain belonging to the genus Fusarium or cells obtained by the filtration of the culture with a compound represented by general formula (II) wherein R , R , and R are each as defined above.
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