公开(公告)号：EP0933422A4

公开(公告)日：2005-02-02

申请号：EP97926214

申请日：1997-06-11

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： UEDA SATOSHI ,  TANAKA MIHO ,  EZAKI MASAMI ,  SAKAMOTO KAZUTOSHI ,  HASHIMOTO SEIJI ,  OOHATA NOBUTAKA ,  TSUBOI MASARU ,  YAMASHITA MICHIO

IPC分类号： A61K38/00 ,  C07K7/56 ,  C12N9/80 ,  C07K5/12 ,  C12N1/14 ,  C12N9/14 ,  C12P21/02

CPC分类号： C12P21/02 ,  A61K38/00 ,  C07K7/56 ,  C12N9/80

摘要： A cyclic lipopeptide acylase which can effectively remove acyl side chains from cyclic lipopeptides, specifically substances FR901379 of general formula (I) and analogues thereof; and a process for the preparation of cyclic peptides by the use of this acylase, wherein R is acyl; R is hydroxyl or acyloxy; R is H or hydroxyl; R is H or hydroxyl; R is H or hydroxysulfonyloxy; and R is H or carbamoyl.

公开(公告)号：EP0885957A4

公开(公告)日：2004-06-09

申请号：EP97905455

申请日：1997-03-06

申请人： FUJISAWA PHARMACEUTICAL CO

发明人： UEDA SATOSHI ,  TANAKA MIHO ,  EZAKI MASAMI ,  SAKAMOTO KAZUTOSHI ,  HASHIMOTO SEIJI ,  OOHATA NOBUTAKA ,  TSUBOI MASARU ,  YAMASHITA MICHIO

IPC分类号： C07K7/56 ,  C12N9/80

CPC分类号： C12R1/465 ,  C07K7/56 ,  C12N9/80

摘要： A cyclic lipopeptide acylase which can effectively remove an acyl side chain from a cyclic lipopeptide, specifically FR901379 represented by general formula (I) or an analogue thereof; and a process for the preparation of a cyclic peptide with the acylase, wherein R1 is acyl, R2 is hydroxy or acyloxy, R3 is hydrogen or hydroxy, R4 is hydrogen or hydroxy, R5 is hydrogen or hydroxysulfonyloxy, and R6 is hydrogen or carbamoyl.