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1.发明公开ANTI-PROSTATE STEM CELL ANTIGEN (PSCA) ANTIBODY COMPOSITIONS AND METHODS OF USE 有权抗前列腺干细胞抗原（PSCA）抗体定向及其用途
公开(公告)号：EP1226177A2
公开(公告)日：2002-07-31
申请号：EP00991385.6
申请日：2000-10-27
申请人： Genentech, Inc.
IPC分类号： C07K16/30 , C12N5/10 , C12N5/16 , C12N15/13 , C12N15/67 , A61K39/395 , A61K47/48 , A61K51/10
CPC分类号： C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/77 , C07K2319/00
摘要： The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
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公开(公告)号：EP0697880B1
公开(公告)日：2001-08-22
申请号：EP94914062.8
申请日：1994-04-06
IPC分类号： A61K38/02 , A61K39/395
CPC分类号： C07K16/2821 , A61K38/00 , C07K14/705 , C07K14/70546 , C07K14/70564 , C07K16/2839 , C07K16/2854 , C07K16/2896
摘要： This invention relates to the inhibition of intercellular adhesion mediated by L-selectin by administering a newly identified L-selectin ligand, CD34. More particularly, the invention concerns a method for inhibiting leukocyte adhesion to endothelial cells by administering an effective amount of an isolated, purified CD34 polypeptide or an antibody capable of binding native CD34.
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公开(公告)号：EP0906433B1
公开(公告)日：2005-06-01
申请号：EP97916257.5
申请日：1997-03-17
申请人： Genentech, Inc.
发明人： LASKY, Laurence, A. , CHENG, Jill
摘要： This invention concerns new non-receptor protein tyrosine phosphatases of the hematopoietic stem cells (PTP HSC). The invention specifically concerns native murine and human PTP HSCs, their analogs in other mammals, and their functional derivatives. The invention further relates to nucleic acid encoding these proteins, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. Assays for identifying agonists and antagonists of the native PTP HSCs, methods for expansion of undifferentiated stem cells, and methods for the induction of stem cell differentiation are also within the scope of the invention.
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公开(公告)号：EP0915970B1
公开(公告)日：2004-09-22
申请号：EP97924502.4
申请日：1997-04-17
申请人： Genentech, Inc.
发明人： LASKY, Laurence, A. , WU, Kai
CPC分类号： C07K14/70564 , C07K2319/00
摘要： The invention concerns members of the endocytic type C lectin family and methods and means for producing them. The native polypeptides of the invention are characterized by containing a signal sequence, a cysteine rich domain, a fibronectin type II domain, 8 type C lectin domains, a transmembrane domain and a cytoplasmic domain. Nucleotide sequences encoding such polypeptides, vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the type C lectins are also within the scope of the invention.
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公开(公告)号：EP0584229B1
公开(公告)日：2003-07-23
申请号：EP92912173.9
申请日：1992-05-06
IPC分类号： C12N15/12 , A61K38/00 , C12N15/62 , C12N15/13 , C12P21/02 , C12N5/10 , C07K14/00 , C12P21/08
CPC分类号： C07K14/70564 , A61K38/00 , C07K14/70596 , C07K16/28 , C07K16/2854 , C07K2317/34 , C07K2319/00
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公开(公告)号：EP0912733B1
公开(公告)日：2006-04-19
申请号：EP97927799.3
申请日：1997-05-22
申请人： GENENTECH, INC.
发明人： CHENG, Jill , LASKY, Laurence, A.
IPC分类号： C12N15/12 , C07K14/705 , C12N5/16 , G01N33/68
CPC分类号： C12N9/16 , C07K14/705
摘要： This invention concerns novel receptor protein tyrosine phosphatase polypeptides. Specifically, this invention concerns the novel receptor protein tyrosine phosphatase lambda which is related to the homotypically adhering receptor protein tyrosine phosphatases kappa and mu . The invention further relates to analogs of these polypeptides in other mammals, functional derivatives thereof, antibodies which are capable of specifically binding to these polypeptides, nucleic acids encoding these polypeptides, vectors containing and capable of expressing such nucleic acid and recombinant host cells transformed with such nucleic acid. Methods for the recombinant production of these receptor protein tyrosine phosphatase polypeptides and assays for identifying agonists and antagonists of these polypeptides are also within the scope of the invention.
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公开(公告)号：EP0639224B1
公开(公告)日：2000-06-28
申请号：EP93910869.2
申请日：1993-04-28
申请人： GENENTECH, INC.
CPC分类号： C07K14/70564 , A61K38/00 , C07K2319/035 , C07K2319/30 , C07K2319/32
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公开(公告)号：EP0915970A1
公开(公告)日：1999-05-19
申请号：EP97924502.0
申请日：1997-04-17
申请人： Genentech, Inc.
发明人： LASKY, Laurence, A. , WU, Kai
CPC分类号： C07K14/70564 , C07K2319/00
摘要： The invention concerns members of the endocytic type C lectin family and methods and means for producing them. The native polypeptides of the invention are characterized by containing a signal sequence, a cysteine rich domain, a fibronectin type II domain, 8 type C lectin domains, a transmembrane domain and a cytoplasmic domain. Nucleotide sequences encoding such polypeptides, vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the type C lectins are also within the scope of the invention.
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公开(公告)号：EP0639224A1
公开(公告)日：1995-02-22
申请号：EP93910869.0
申请日：1993-04-28
申请人： GENENTECH, INC.
IPC分类号： C12N15 , A61K38 , A61P17 , A61P19 , A61P25 , A61P29 , C07K14 , C07K16 , C07K19 , C12N1 , C12N5 , C12P21 , C12R1
CPC分类号： C07K14/70564 , A61K38/00 , C07K2319/035 , C07K2319/30 , C07K2319/32
摘要： This invention concerns selectin variants having an amino acid alteration at a site or sites of a selectin lectin domain amino acid sequence within a region defined by binding sites recognized by blocking monoclonal antibodies to the corresponding selectin unaltered in the lectin domain. Nucleotide sequences encoding such variants, expression vectors containing such nucleotide sequences, and host cells transformed with such expression vectors are also within the scope of the invention.
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10.发明公开TYROSINE PHOSPHORYLATED CLEAVAGE FURROW-ASSOCIATED PROTEINS (PSTPIPs) 失效及细胞分裂RUT相关蛋白酪氨酸磷酸化（PSTPIPS）
公开(公告)号：EP0980426A1
公开(公告)日：2000-02-23
申请号：EP98908458.7
申请日：1998-01-30
申请人： Genentech, Inc.
摘要： This invention concerns new PSTPIP polypeptides which are bound by and dephosphorylated by the PEST family of protein tyrosine phosphatases. The invention specifically concerns native murine PSTPIP polypeptides and their homologues in other mammals, and their functional derivatives. The invention further relates to nucleic acids encoding these proteins, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. Methods for inducing the polymerization of actin monomers in eukaryotic cells and assays for identifying antagonists and agonists of the PSTPIP polypeptides of the present invention are also provided.
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