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公开(公告)号：EP3180000A1
公开(公告)日：2017-06-21
申请号：EP15832111.7
申请日：2015-08-12
IPC分类号： A61K31/40 , A61K31/138 , A61P35/00 , G01N33/574 , A61B5/00
CPC分类号： G01N33/57496 , A61K31/59 , A61K33/06 , A61K45/00 , A61P35/00 , G01N33/57407 , G01N33/57492
摘要： The present invention provides a novel approach to cancer diagnosis and therapy of cancer by providing compositions and methods for the identification and specific targeting of the cancer stem cell populations present in a tumour to eradicate, or slow or prevent tumour (5) growth and spread, including the potential for tumour metastasis, by modulation of the Renin-Angiotensin System including, but not limited to, Renin Receptor, Angiotensin II Receptor (2) and a secreted form of the Renin Receptor.
摘要翻译： 本发明通过提供用于鉴定和特异性靶向存在于肿瘤中的癌症干细胞群以根除或减缓或预防肿瘤（5）生长和扩散的组合物和方法，提供了癌症的癌症诊断和治疗的新方法， 包括通过调节肾素 - 血管紧张素系统（包括但不限于肾素受体，血管紧张素II受体（2）和肾素受体的分泌形式）的肿瘤转移潜力。
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公开(公告)号：EP4096648A1
公开(公告)日：2022-12-07
申请号：EP21747762.9
申请日：2021-01-29
发明人： DAVIS, Paul Frank , MACKAY, Sean Marshall , PATERSON, Erin Fay , TAN, Swee Thong , TAN, Eng Wui
IPC分类号： A61K31/138 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/433 , A61K31/435 , A61K31/513 , A61K31/551 , A61K9/00 , A61K9/06 , A61K9/127 , A61P17/02 , A61P35/00
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公开(公告)号：EP3576746A1
公开(公告)日：2019-12-11
申请号：EP18747771.6
申请日：2018-01-31
IPC分类号： A61K31/616 , A61K31/415 , A61K31/138 , A61K31/12 , A61K31/165 , A61K35/00
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公开(公告)号：EP3384285A1
公开(公告)日：2018-10-10
申请号：EP16871115.8
申请日：2016-11-30
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , C12N5/0606 , G01N2333/705 , G01N2333/96483 , G01N2800/7052
摘要： The present invention provides a novel approach to the diagnosis, treatment and management of a fibrotic lesion by providing compositions and methods for the identification and specific targeting of the embryonic stem cell populations known to be associated with a fibrotic lesion, by modulation of the Renin-Angiotensin System.
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