公开(公告)号：EP3384285A1

公开(公告)日：2018-10-10

申请号：EP16871115.8

申请日：2016-11-30

申请人： Gillies Mcindoe Research Institute

发明人： TAN, Swee Thong ,  DAVIS, Paul Frank ,  ITINTEANG, Tinte

IPC分类号： G01N33/50

CPC分类号： G01N33/6893 ,  C12N5/0606 ,  G01N2333/705 ,  G01N2333/96483 ,  G01N2800/7052

摘要： The present invention provides a novel approach to the diagnosis, treatment and management of a fibrotic lesion by providing compositions and methods for the identification and specific targeting of the embryonic stem cell populations known to be associated with a fibrotic lesion, by modulation of the Renin-Angiotensin System.

公开(公告)号：EP2918600A4

公开(公告)日：2016-05-11

申请号：EP13852655

申请日：2013-11-06

申请人： UNIV MIYAZAKI

发明人： KITAMURA KAZUO ,  NAGATA SAYAKA ,  ASADA YUJIRO

IPC分类号： C07K14/435 ,  C07K16/18 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K14/575 ,  C07K7/14 ,  C07K16/26 ,  C07K2317/34 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/96433 ,  G01N2333/96483 ,  G01N2500/04 ,  G01N2800/32 ,  G01N2800/347

摘要： An object of the present invention is to discover a novel component of the renin-angiotensin system (RAS) and to provide the same as a novel biomarker of a cardiovascular disease or a renal disease. This invention provides a novel peptide associated with the renin-angiotensin system comprising the amino acid sequence as shown in SEQ ID NO: 1 or an amino acid sequence derived therefrom by deletion, substitution, or addition of one to several amino acids other than the asparagine residue at position 14 and an N-linked glycan added thereto at the asparagine residue at position 14. With the use of such peptide as a biomarker, a renal disease or a cardiovascular disease can be diagnosed at an early stage in a simple manner without imposing burdens on a subject.

公开(公告)号：EP2817632A1

公开(公告)日：2014-12-31

申请号：EP13705485.4

申请日：2013-02-22

申请人： Centre National de la Recherche Scientifique (CNRS) ,  College de France ,  Ecole Normale Supérieure ,  INSERM - Institut National de la Santé et de la Recherche Médicale ,  Université Pierre et Marie Curie (Paris 6)

发明人： MARIN, Philippe ,  THOUVENOT, Eric ,  NGUYEN, Geneviève ,  GROSZER, Matthias

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/705 ,  G01N2333/96483 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/285 ,  G01N2800/52

摘要： A new dual biomarker of neurodegeneration and of neuroregeneration

公开(公告)号：EP2817632B1

公开(公告)日：2018-04-25

申请号：EP13705485.4

申请日：2013-02-22

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  College de France ,  Ecole Normale Supérieure ,  INSERM - Institut National de la Santé et de la Recherche Médicale ,  Université Pierre et Marie Curie (Paris 6)

发明人： MARIN, Philippe ,  THOUVENOT, Eric ,  NGUYEN, Geneviève ,  GROSZER, Matthias

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/705 ,  G01N2333/96483 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/285 ,  G01N2800/52

摘要： A new dual biomarker of neurodegeneration and of neuroregeneration

公开(公告)号：EP2918600A1

公开(公告)日：2015-09-16

申请号：EP13852655.3

申请日：2013-11-06

申请人： University of Miyazaki

发明人： KITAMURA, Kazuo ,  NAGATA, Sayaka ,  ASADA, Yujiro

IPC分类号： C07K14/435 ,  C07K16/18 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K14/575 ,  C07K7/14 ,  C07K16/26 ,  C07K2317/34 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/96433 ,  G01N2333/96483 ,  G01N2500/04 ,  G01N2800/32 ,  G01N2800/347

摘要： An object of the present invention is to discover a novel component of the renin-angiotensin system (RAS) and to provide the same as a novel biomarker of a cardiovascular disease or a renal disease. This invention provides a novel peptide associated with the renin-angiotensin system comprising the amino acid sequence as shown in SEQ ID NO: 1 or an amino acid sequence derived therefrom by deletion, substitution, or addition of one to several amino acids other than the asparagine residue at position 14 and an N-linked glycan added thereto at the asparagine residue at position 14. With the use of such peptide as a biomarker, a renal disease or a cardiovascular disease can be diagnosed at an early stage in a simple manner without imposing burdens on a subject.

摘要翻译： 本发明的目的是发现肾素 - 血管紧张素系统（RAS）的新型成分，并提供与心血管疾病或肾脏疾病的新型生物标志物相同的作用。 本发明提供与肾素 - 血管紧张素系统相关的新型肽，其包含如SEQ ID NO：1所示的氨基酸序列或通过缺失，取代或添加天冬酰胺以外的一至几个氨基酸而衍生的氨基酸序列 在第14位的天冬酰胺残基处加入14位的残基和加入其中的N-连接的聚糖。使用这样的肽作为生物标志物，可以以简单的方式在早期诊断肾脏疾病或心血管疾病，而不施加 一个主题的负担

公开(公告)号：EP2768971A1

公开(公告)日：2014-08-27

申请号：EP12777909.8

申请日：2012-10-22

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Université de Lorraine ,  Centre Hospitalier Et Universitaire De Nancy (CHU)

发明人： ZANNAD, Faiez ,  ROSSIGNOL, Patrick

IPC分类号： C12Q1/37 ,  G01N33/573

CPC分类号： C07K16/40 ,  A61K45/06 ,  C12Q1/37 ,  G01N33/573 ,  G01N2333/96483 ,  G01N2800/32

摘要： The present invention relates to methods and kits for detecting cardiac remodeling in subjects without clinical signs of heart failure. The present invention also relates to methods and pharmaceutical compositions for the prevention and the treatment of cardiac remodeling.

摘要翻译： 本发明涉及用于检测没有心力衰竭临床症状的受试者心脏重塑的方法和试剂盒。 本发明还涉及用于预防和治疗心脏重塑的方法和药物组合物。