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公开(公告)号：EP2788483A1
公开(公告)日：2014-10-15
申请号：EP12816132.0
申请日：2012-12-05
IPC分类号： C12N15/09
摘要： The present invention relates to an expression cassette useful for the expression of a polynucleotide sequence encoding a polypeptide.
摘要翻译： 本发明涉及可用于表达编码多肽的多核苷酸序列的表达盒。
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公开(公告)号：EP2398829A2
公开(公告)日：2011-12-28
申请号：EP10706363.8
申请日：2010-02-23
IPC分类号： C07K16/28
CPC分类号： C07K16/3061 , A61K2039/505 , C07K16/2803 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to humanized antibodies or fragments thereof that bind to human CD 19. More specifically, the present invention relates to a humanized antibody or fragment thereof that binds to human CD 19 comprising a heavy chain CDRl comprising the amino acid sequence of SEQ ID NO: 27, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 28, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 29; and/or comprising a light chain CDRl comprising the amino acid sequence of SEQ ID NO: 30, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 31 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 32.
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3.发明公开EXPRESSION CONSTRUCTS AND METHODS FOR SELECTING HOST CELLS EXPRESSING POLYPEPTIDES 审中-公开VERFAHREN ZUR AUSWAHL VON POLYPEPTIEXEXPRIMIERENDEN WIRTSZELLEN表演表演
公开(公告)号：EP3110950A1
公开(公告)日：2017-01-04
申请号：EP15707625.8
申请日：2015-03-02
IPC分类号： C12N15/09
CPC分类号： G01N33/56966 , C07K14/705 , C07K16/00 , C07K2317/31 , C07K2317/52 , C07K2317/622 , C12N15/1037 , C12N15/85 , C12N2830/42 , C12N2830/50 , C12P21/00 , G01N33/6854
摘要： The invention relates to an expression construct for the soluble expression of polypeptides in host cells and for the expression of polypeptides on the surface of host cells, using alternative splicing. The amount of cell membrane expression of polypeptides such as antibodies, antibody fragments and bispecific antibodies can be correlated directly to the amount of soluble polypeptide expressed. In the case of bispecific antibodies, cell membrane expression of heterodimer and homodimer products can be correlated directly to the soluble expression of these products, thereby aiding selection of a desired producer clone.
摘要翻译： 本发明涉及使用选择性剪接在宿主细胞中可溶性表达多肽并在宿主细胞表面上表达多肽的表达构建体。 多肽如抗体，抗体片段和双特异性抗体的细胞膜表达量可直接与表达的可溶性多肽的量相关。 在双特异性抗体的情况下，异二聚体和同二聚体产物的细胞膜表达可以直接与这些产物的可溶性表达相关，从而有助于选择所需的生产者克隆。
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4.发明公开EXPRESSION CONSTRUCTS AND METHODS FOR EXPRESSING POLYPEPTIDES IN EUKARYOTIC CELLS 审中-公开表达构建体和真核细胞中表达多肽的方法
公开(公告)号：EP3030579A1
公开(公告)日：2016-06-15
申请号：EP14749786.1
申请日：2014-08-05
CPC分类号： C07K16/468 , C07K16/32 , C07K2317/14 , C07K2317/52 , C07K2317/622 , C07K2317/64 , C12N15/85 , C12N2840/20 , C12N2840/445 , C12P21/02
摘要： The invention relates to an expression construct for the expression of polypeptides in host cells using alternative splicing. The expression construct can be used for the expression of polypeptides such as antibodies, antibody fragments and bispecific antibodies by expressing the gene products required for protein expression at the ratio leading to the highest titres or the best product quality profile.
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公开(公告)号：EP2788483B1
公开(公告)日：2018-06-27
申请号：EP12816132.0
申请日：2012-12-05
IPC分类号： C12N15/09
摘要： The present invention relates to an expression cassette useful for the expression of a polynucleotide sequence encoding a polypeptide.
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公开(公告)号：EP2245069B1
公开(公告)日：2014-06-18
申请号：EP09703856.6
申请日：2009-01-22
发明人： LAZARIDES, Elias , WOODS, Catherine , FAN, Xiaomin , HOU, Samuel , MOTTL, Harald , BLEIN, Stanislas , BERTSCHINGER, Martin
IPC分类号： C07K16/36 , C12N15/13 , A61K39/395 , A61P7/02
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2245069A1
公开(公告)日：2010-11-03
申请号：EP09703856.6
申请日：2009-01-22
发明人： LAZARIDES, Elias , WOODS, Catherine , FAN, Xiaomin , HOU, Samuel , MOTTL, Harald , BLEIN, Stanislas , BERTSCHINGER, Martin
IPC分类号： C07K16/36 , C12N15/13 , A61K39/395 , A61P7/02
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure relates to humanized antibodies or binding fragments thereof specific for human von Willebrand factor (vWF), methods for their preparation and use, including methods for treating vWF mediated diseases or disorders.
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